Bio-inspired self-assembled bacteriochlorin nanoparticles for superior visualization and photothermal ablation of tumors

Zhang, X; Ma, Yating; Zhang, Xiaojian; Pang, Xin; Yang, Zhiheng

doi:10.1016/j.biopha.2023.115014

Cited by 6 publications

(3 citation statements)

References 26 publications

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“…9,10 The distinctive capacity of red and near-infrared (NIR) light to penetrate the skin more deeply than other wavelengths across the light spectrum makes them appealing for a variety of applications in healthcare, bioimaging, and phototherapy. [11][12][13] However, conventional red/NIR TADF OLEDs exhibit notable external quantum efficiency (EQE) roll-off at luminance levels exceeding 1000 cd m À2 when compared to their blue and green counterparts, limiting their practical utility. [14][15][16] The significant decrease in efficiency at high luminance levels can be attributed to factors such as unbalanced charge transport, inefficient energy transfer from the host to dopant, and prolonged fluorescence lifetime of the emitters, resulting in elevated triplet exciton density and subsequent exciton quenching mechanisms including triplet-polaron quenching (TPQ), triplet-triplet annihilation (TTA), and electric-field-induced exciton dissociation.…”

Section: Introductionmentioning

confidence: 99%

A red thermally activated delayed fluorescence emitter with mitigated efficiency roll-off via a π-stacked multiple donor–acceptor structure

Song,

Yu,

Feng

et al. 2024

J. Mater. Chem. C

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Section: Introductionmentioning

confidence: 99%

A red thermally activated delayed fluorescence emitter with mitigated efficiency roll-off via a π-stacked multiple donor–acceptor structure

Song,

Yu,

Feng

et al. 2024

J. Mater. Chem. C

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“…33 In many previous studies, the introduction of PTT can give significantly enhanced inhibition on tumor growth, which can even achieve full ablation of solid tumors. [34][35][36] Although previous studies have shown the promise of multi-drug ND and PTT in cancer management, the integration of these functions into one drug delivery platform using a facile method is usually difficult as many previously reported NDs usually require complicated preparation procedures. 37,38 Here, in this study, with the aim to devise an ND platform to achieve enhanced anticancer effects, a size-tunable dual drug loaded ND was first developed by integrating curcumin (Cur) and doxorubicin (Dox) into the same ND (Cur-Dox ND) using ferric ion as the linker and PVP as the stabilizer and regulator.…”

Section: Introductionmentioning

confidence: 99%

Polyvinylpyrrolidone Assisted One-Pot Synthesis of Size-Tunable Cocktail Nanodrug for Multifunctional Combat of Cancer

Wang,

Pan,

Chen

et al. 2024

IJN

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Background The in vivo barriers and multidrug resistance (MDR) are well recognized as great challenges for the fulfillment of antitumor effects of current drugs, which calls for the development of novel therapeutic agents and innovative drug delivery strategies. Nanodrug (ND) combining multiple drugs with distinct modes of action holes the potential to circumvent these challenges, while the introduction of photothermal therapy (PTT) can give further significantly enhanced efficacy in cancer therapy. However, facile preparation of ND which contains dual drugs and photothermal capability with effective cancer treatment ability has rarely been reported. Methods In this study, we selected curcumin (Cur) and doxorubicin (Dox) as two model drugs for the creation of a cocktail ND (Cur-Dox ND). We utilized polyvinylpyrrolidone (PVP) as a stabilizer and regulator to prepare Cur-Dox ND in a straightforward one-pot method. Results The size of the resulting Cur-Dox ND can be easily adjusted by tuning the charged ratios. It was noted that both loaded drugs in Cur-Dox ND can realize their functions in the same target cell. Especially, the P-glycoprotein inhibition effect of Cur can synergistically cooperate with Dox, leading to enhanced inhibition of 4T1 cancer cells. Furthermore, Cur-Dox ND exhibited pH-responsive dissociation of loaded drugs and a robust photothermal translation capacity to realize multifunctional combat of cancer for photothermal enhanced anticancer performance. We further demonstrated that this effect can also be realized in 3D multicellular model, which possibly attributed to its superior drug penetration as well as photothermal-enhanced cellular uptake and drug release. Conclusion In summary, Cur-Dox ND might be a promising ND for better cancer therapy.

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“…Similarly, Wang et al reported the development of a photothermal-assisted photocatalytic system using graphene oxide as a photothermal substrate and g-C 3 N 4 as a photocatalyst, which exhibited excellent stability and reusability for the degradation of antibiotics in wastewater treatment [31]. However, most of the above-mentioned researches on photothermal-assisted photocatalysis is realized by combining photothermal materials, which often has the disadvantages of a complex preparation process, poor stability, and high cost [32,33]. Considering this, it is of great significance to design an ultrathin g-C 3 N 4 nanosheet with its own photothermal effect for the photothermal-assisted photocatalytic degradation of antibiotics.…”

Section: Introductionmentioning

confidence: 99%

Photothermal-Assisted Photocatalytic Degradation of Tetracycline in Seawater Based on the Black g-C3N4 Nanosheets with Cyano Group Defects

Nguetsa Kuate,

Chen,

et al. 2023

Catalysts

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As a broad-spectrum antibiotic, tetracycline (TC) has been continually detected in soil and seawater environments, which poses a great threat to the ecological environment and human health. Herein, a black graphitic carbon nitride (CN-B) photocatalyst was synthesized by the one-step calcination method of urea and phloxine B for the degradation of tetracycline TC in seawater under visible light irradiation. The experimental results showed that the photocatalytic degradation rate of optimal CN-B-0.1 for TC degradation was 92% at room temperature within 2 h, which was 1.3 times that of pure CN (69%). This excellent photocatalytic degradation performance stems from the following factors: (i) ultrathin nanosheet thickness reduces the charge transfer distance; (ii) the cyanogen defect promotes photogenerated carriers’ separation; (iii) and the photothermal effect of CN-B increases the reaction temperature and enhances the photocatalytic activity. This study provides new insight into the design of photocatalysts for the photothermal-assisted photocatalytic degradation of antibiotic pollutants.

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Bio-inspired self-assembled bacteriochlorin nanoparticles for superior visualization and photothermal ablation of tumors

Cited by 6 publications

References 26 publications

A red thermally activated delayed fluorescence emitter with mitigated efficiency roll-off via a π-stacked multiple donor–acceptor structure

A red thermally activated delayed fluorescence emitter with mitigated efficiency roll-off via a π-stacked multiple donor–acceptor structure

Polyvinylpyrrolidone Assisted One-Pot Synthesis of Size-Tunable Cocktail Nanodrug for Multifunctional Combat of Cancer

Photothermal-Assisted Photocatalytic Degradation of Tetracycline in Seawater Based on the Black g-C3N4 Nanosheets with Cyano Group Defects

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