Bio-inspired self-assembled molecular capsules

Abstract

Bowl shaped molecules are useful for making molecular capsules with suitable non-covalent bonds. We appended cyclotriguaiacylene with biologically important adenine and thymine to make capsule in solution by hydrogen bonding.

Autotemplate Microcapsules of CaCO3/Pectin and Nonstoichiometric Complexes as Sustained Tetracycline Hydrochloride Delivery Carriers

“…The composite capsules combine the properties of organic and inorganic components and can integrate multiple functionalities as well as form hierarchical structures. A large variety of methods, including molecular self-assembly, layer-by-layer assembly, and biomimetic mineralization, were developed for the design and synthesis of composite capsules. Many efforts to prepare composite capsules have been focused on using sacrificial “hard template” (silica spheres, porous carbon) and “soft template” (emulsion droplets, surfactant vesicles, block copolymer micelles) methods.…”

Complex calcium carbonate/polymer microparticles as carriers for aminoglycoside antibiotics

“…11S †) sustained by Higuchi model. According to the Table 3 The maximum release after 10 h, and the release constants (k Hthe Higuchi constant, k rthe release rate constant), the diffusion coefficient (n r ), and regression coefficients (R 2 ) calculated using the Higuchi and Korsmeyer-Peppas mathematical models for pectin-CaCO 3 and NPEC-CaCO 3 Korsmeyer-Peppas model, the main drug release mechanism is correlated to the n r values: n r < 0.4, Fick's diffusion (case-I); 0.4 < n r < 0.85, anomalous or non-Fick's transport; n r > 0.85, case-II transport (zero order). As shown in Table 3, n r values are greater than 0.85 for all investigated samples, indicating a case II transport mechanism of STR and KAN diffusion.…”

“…In the last few years many efforts have been made to advance current drug therapy, with different carrier/drug systems being tested for controlled drug delivery, [1][2][3] with or without interaction between the drug and carrier. The carrier could be considered as a vehicle which delivers the drugs to their appropriate target and which allows the protection of sensitive drugs from unwanted reaction and reduces or even eliminates bad tastes or odours.…”

“…17,18 Weak polyelectrolytes are polymers which have in their structure weak acidic (carboxylic acids) or weak basic groups (primary and secondary amine groups) that either accept or release protons in response to environmental pH changes. 12 The use of weak polymers in CaCO 3 composites preparation allows the control of materials stability on the environmental pH variation, from pH 5.5 (of CaCO 3 itself) up to strong acidic pH (2)(3). 8,9 Streptomycin (STR) and kanamycin (KAN) sulfate are broad spectrum aminoglycoside antibiotics.…”

Self-assembled Cages and Capsules Using Cyclotriveratrylene-type Scaffolds

“…Nucleobases can also be used as hydrogen-bonding groups for CTG heterocapsules, and a 1:1 mixture of a tris-adenineappended CTG and a tris-thymine-appended CTG gives a capsule in CD 3 OD:CCl 4 solution without the need for a templating guest. 19 Homodimeric capsules of type (2) 2 ¢F, where 2 is a tris(4-ureidopyrimidinone)-appended CTG and F is an encapsulated fullerene, have been reported by de Mendoza and co-workers (Chart 3). 5,20,21 Binding of the fullerene templates the capsule formation in solution.…”