Bio‐inspired Underwater Super‐Oil‐Wettability for Controlling Platelet Adhesion

Abstract

Control promotion and prevention of platelet adhesion are important for various biomedical applications. In the past, surface topography and chemical modifications have been commonly utilized for tailoring the promotion and prevention of platelet adhesion. Recently, lotus-leafinspired superhydrophobicity has appeared as an efficient avenue to prevent platelet adhesion. However, such extreme water repellent interfaces fail to perform upon prolonged and continuous exposure to aqueous phase. In this communication, the strategic use of a catalyst-free 1,4conjugate addition reaction between amine and acrylate allowed us to investigate the impact of two distinct underwater oil-wettability on platelet adhesion activity. While underwater superoleophobicity inhibited plateletadhesion, a highly aggregated fibrous network of adhered platelets was observed on underwater superoleophilic coating. Further, this biocompatible and haemocompatible underwater superoleophobic multilayer coating was deposited on a commercially available catheter tube to examine its potential towards the prevention of platelet attachment.

Role of chemistry in bio-inspired liquid wettability

“…10A-D). 11 Bio-mimicking this oil-repellence behavior underwater finds extensive applications in underwater oil droplet manipulation, 149 antiplatelet adhesion, 150,151 underwater sensors, 152 remediation of oil spillages, 56,[153][154][155] etc. Such interfaces are efficient in performing at extremes of temperatures, a condition where superhydrophobicity is compromised.…”

“…Furthermore, the effect of tailoring the embedded oil wettability of this reactive polymeric multilayers underwater was analyzed for platelet adhesion. 234 It was revealed that underwater superoleophilicity (after octadecylamine modification) facilitated platelet growth due to the presence of an entrapped air layer, whereas the entrapped water layer in underwater superoleophobicity (glucamine modified) inhibited the platelet growth. Thus, this unique feature of chemical reactivity was utilized to control the extreme oil wettability underwater, which further had an impact on platelet adhesion.…”

Reactive Multilayer Coating As Versatile Nanoarchitectonics for Customizing Various Bioinspired Liquid Wettabilities

“…91 Lotus-leafmimicked superhydrophobic surfaces have been recently recognized as a suitable and efficient avenue for preventing the adhesion of platelets. 92 The scope of the study of an RMLC that was used to derive two extremes of UW oil wettability 93 was extended to analyze the platelet-adhesion activity. It was observed that UW superoleophobicity inhibited platelet adhesion, and the UW superoleophilic coating promoted platelets to adhere, resulting in a highly aggregated fibrous network of adhered platelets (Figure 9I and J).…”

“…This work was further extended to investigate its potential toward the prevention of platelet attachment on a commercially available catheter tube by using the biocompatible and hemocompatible UW superoleophobic multilayer coating. 93 Thus, different, durable, and functional bioinspired wettabilities that were derived from the RMLC were observed to be highly efficient for various prospective applications.…”

Micro/Nanopatterned Superhydrophobic Surfaces Fabrication for Biomolecules and Biomaterials Manipulation and Analysis

“…These have the final purpose of both decreasing the fluid friction in the device to avoid clogging of tubes and apertures, and, at the same time, decreasing bacterial adhesion to limit biofouling when in contact with blood or bodily fluids [30,31]. These coatings are frequently based on disordered selfassembled micro/nanostructures that contemporarily diminish fluid friction and provide antiseptic treatment with improved liquid transport properties [32][33][34][35]. Among these activities, a special mention is deserved for the studies on the specific case of surfaces aimed at improving interaction with blood, to avoid blood cell disruption for devices to handle blood in a liquid state.…”