Bio-metal-organic frameworks for molecular recognition and sorbent extraction of hydrophilic vitamins followed by their determination using HPLC-UV

Abstract

In this work, a bio metal-organic framework (bio-MOF) derived from the amino acid Lserine has been prepared in bulk form and the resulting material was evaluated as selective sorbent for the molecular recognition and extraction of B-vitamins. The functional pores of bio-MOF, with formula {Cu II 6Ca II [(S,S)-serimox]3(OH)2(H2O)}39H2O (Cu-Serimox-Ca), exhibit high amounts of hydroxyl groups jointly other directing supramolecular hostguest interactions allowed a selective recognition of B-vitamins by bio-MOF. Singlecrystal X-ray diffraction studies reveal the specific B-vitamin binding sites and the existence of multiple hydrogen bonds between these target molecules and the framework.It offered unique snapshots to accomplish a highly efficient capture of these solutes in complex aqueous matrices. Indeed, this material demonstrated a high potential as solidphase extraction sorbent with remarkable reproducibility and low detection limits (between 0.4 to 1.4 ng mL -1 ). The application of bio-MOF was successfully evaluated by preconcentrating these hydrophilic vitamins in fruit juices and energy drinks.

Highly Efficient Removal of Neonicotinoid Insecticides by Thioether-Based (Multivariate) Metal–Organic Frameworks

“…The selection of this family of MOFs is not accidental. This is based on their good mechanical properties, which have already permitted their processability as pellets or mixed matrix membranes, their proven air and water stability (neutral and basic media), and their excellent performances in the removal of both inorganic , (Hg 2+ ) and organic contaminants (dyes or vitamins, , recently reported for 1 – 4 , in the presence of other metal cations and inorganic anions usually present in potable drinking water. ,,, The main reasons that lie at the origin of such remarkable capture properties are twofold: (i) these MOFs feature channels decorated with different functional groups, which can be tuned depending on the nature of the chosen amino acid residue (−CH 2 OH, −CH­(CH 3 )­OH, −CH 2 SCH 3 , and/or −CH 2 CH 2 SCH 3 ); and (ii) these amino acid residues exhibit a high degree of adaptability, being capable of accommodating and adjusting to guest molecules by maximizing host–guest interactions with the contaminant.…”

Metal–organic frameworks in chiral separation of pharmaceuticals

“…109 In the extraction of vitamin B, L-serine has been extensively used as the Bio-MOF because the morphology of its pores matches with the guest vitamin B and its hydrophilic channels immensely benefit the interaction with analytes. 109,111 The assimilation of amino acid ligands in MOFs has captivated attention due to amino acid's inherent chirality that offers high enantioselectivity. 110,112 A series of 3D-BioMOFs have been prepared by incorporating chiral amino acids as ligands and achiral tetrazolate coligands such as Zn 4 (5-mtz) 6 (L-Ala) 2 .2DMF (1L), Zn 4 (5-mtz) 6 (D-Ala) 2 .…”

“…The Bio‐MOFs based on amino acids as a ligand are widely used to formulate the selective adsorption of host molecules 109 . In the extraction of vitamin B, L‐serine has been extensively used as the Bio‐MOF because the morphology of its pores matches with the guest vitamin B and its hydrophilic channels immensely benefit the interaction with analytes 109,111 . The assimilation of amino acid ligands in MOFs has captivated attention due to amino acid's inherent chirality that offers high enantioselectivity 110,112 .…”

Development of biological metal–organic frameworks designed for biomedical applications: from bio-sensing/bio-imaging to disease treatment

“…Amino acid based bio-MOFs have also been designed for selective guest molecule adsorption. For example, the bio-MOF derived from l -serine can be used as an adsorbent for B-vitamin molecular recognition and extraction; 37 a zinc glutamate bio-MOF was synthesized and supported on cellulose fabrics for drug loading and controlled release. 38 Nitric oxide (NO) and 5-fluorouracil (5-FU) loaded in the bio-MOF were controlled released relying on the acid environment of pathological sites.…”