BIO-NAIL: a bacterial cellulose dressing as a new alternative to preserve the nail bed after avulsion

Abstract

Avulsion of the nail plate is the most accomplished surgical procedure among the nail apparatus surgeries. Since it is not possible to use the removed nail to cover the nail bed, some materials have been suggested, however, they are generally not available for use and often at a high cost. To evaluate the use of Bacterial Cellulose (BC) dressing as a biological nail (Bio-Nail) after partial or total avulsion of the nail plate. Twenty-six candidates for nail avulsion, were randomized into two groups: Control, using Vaseline with gauze (11 patients) and Experimental group, BC group, using the Bio-Nail (15 patients). The patients were followed up during the 180-day period. The distribution of the patients in the groups was homogeneous for both sociodemographic and clinical data. The occurrence of infection (1 case in the control group) was not statistically relevant. The BC group had lower pain intensity (p = 0.011) with earlier temporal resolution when compared to the control group (p = 0.003). The BC group presented earlier reepithelization (p = 0.022) and better quantitative (p = 0.021) and qualitative conditions (p = 0.011) for the exudate. Regarding satisfaction, all the patients were satisfied. Good preservation of the nail plate area was observed in the BC group at the end of the 180-day period (p = 0.024). Average time of BC dressing permanence was 16.4 ± 7.1 days. BC showed to be appropriate as a dressing after partial or total avulsion of the nail plate. BC is a Bio-Nail promising for nail bed healing.

Bacterial cellulose an effective material in the treatment of chronic venous ulcers of the lower limbs

“…Clinically, there was a reduction in exsudativas CVUs with loss of subcutaneous tissue, this decrease is directly associated with superficialization and epithelization of the wounds, a result similar to studies with the theme [26,51].…”

“…The success achieved by the present study may be associated with a longer treatment time and the association of BC gel with the multiperforated film. In preclinical studies, BC gel has demonstrated the ability of vascular neoformation, which might promote an increase of granulation tissues [21,22,51].…”

“…The reduction on the number of dressing changes in the EG promoted by its longer permanence on the CVU was significantly higher in comparison to the GC, p = 0.001. The BC, gel and film associated are easy to handle and can remain on the CVU for a long time or even remain on the lesion until complete epithelialization [29,30,51]. By being adhered to the CVU for a longer period, the multi-perforated BC film acts as a second skin, reducing the need of direct manipulation with frequent dressing changes, and allows the direct hygiene of the ulcerated limb during shower.…”

Bacterial Cellulose Properties Fulfilling Requirements for a Biomaterial of Choice in Reconstructive Surgery and Wound Healing

“…Thanks to proteolytic enzymes, gram-negative microflora causes faster wound cleansing, preparing for further treatment with a free skin graft (Czaja et al, 2004). According to clinical data, due to their flexibility, bacterial cellulose dressings are particularly recommended for the treatment of burn wounds in anatomically complex places (ears, face, joint area, hands, feet, genitals) (Oliveira et al, 2020). It has also been shown that combining the dressing with antiseptics, such as silver nitrate, hydroxyquinoline sulphate or boric acid, has a positive effect on reducing burn wound infection (Czaja et al, 2004).…”

Segurança e eficácia da celulose bacteriana obtida a partir do melaço de cana-de-açúcar no processo de cicatrização e remodelamento tecidual: uma revisão narrativa

“…Figura 1-Membrana de celulose bacteriana associada a esponja Fonte: Foto obtida do estudo de Oliveira et al, (2020. Research, Society and Development, v. 10, n. 16, e50101622773, 2021(CC BY 4.0) | ISSN 2525-3409 | DOI: http://dx.doi.org/10.33448/rsd-v10i16.22773 Silveira et al (2016, Magalhães et al (2020) e Oliveira et al (2020) destacaram-se ao criar inovações com a CB para induzir o remodelamento tecidual ao testa-la em área de autoenxerto, utiliza-la como unha (Bio-nail) em pacientes pós avulsão ungueal e no tratamento de tímpano perfurado. Nesses estudos foram avaliados parâmetros semelhantes como tempo de epitelização, intensidade da dor e adesão.…”