Bio-nanocomposite IPN for Biomedical Application

Ismail, Noor Azizi; Razali, Mohd Hasmizam

doi:10.1007/978-981-15-0283-5_12

Cited by 2 publications

(2 citation statements)

References 110 publications

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“…However, there are some exceptions such as boronic esters, which can exchange at room temperature (rt) and show creep deformation . It was found that the incorporation of two or more dynamic chemistries together should result in materials with complementary properties. − …”

Section: Introductionmentioning

confidence: 99%

Tuning Dual-Dynamic Network Materials through Polymer Architectural Features

Watuthanthrige

Dunn

Dolan

et al. 2022

ACS Appl. Polym. Mater.

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Dynamic materials are known for their self-healing, adhesive, and shape memory applications. Interpenetrating networks (IPNs) are types of materials that can hold dual-dynamic crosslinkers to show complementary chemical and mechanical properties. There have been a number of research studies exploring the dynamic chemistries involved in IPN materials. Not only the bond type but also the polymer network architecture play an important role in governing IPN material properties. In this study, we show that network architectural features are as much as important as studying the dynamic chemistries using an IPN system with quadrupole hydrogen (H) bonding and thiol-Michael (TM) bonding. This work varied network types, chain lengths, dynamic bond compositions, crosslink densities, and crosslink distributions within a system to explore their effects on the thermomechanical properties. The synergetic effects of H and TM bonds revealed excellent stress relaxation and self-healing at room temperature and elevated temperatures. Increment of chain length and crosslink density enhanced the strength of the materials to as high as 3.5 MPa, while the crosslink distribution boosted the creep resistance under an applied force. Furthermore, complementary H and TM bonding assisted in improving the adhesive properties in these materials to hold up to 2 kg weight with the adhered wood strips.

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Section: Introductionmentioning

confidence: 99%

Tuning Dual-Dynamic Network Materials through Polymer Architectural Features

Watuthanthrige

Dunn

Dolan

et al. 2022

ACS Appl. Polym. Mater.

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“…The resultant bionanocomposites exhibit improved thermal, optical, mechanical, magnetic, photoelectronic and biological properties ( Zia et al, 2020 ). These biohybrid finds application in various fields including; food packaging ( Zubair and Ullah, 2020 ), biomedical materials ( Ismail and Razali (2020) ), drug delivery systems ( Patwekar, 2016 ), agriculture sector ( Zhang et al, 2020 ), sensing and electronic materials ( Burrs et al, 2015 , Liu et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Prospective of biosynthesized L.satiVum oil/PEG/Ag-MgO bionanocomposite film for its antibacterial and anticancer potential

Amina

Musayeib

Al-Hamoud

et al. 2021

Saudi Journal of Biological Sciences

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A substantial interest has been manifested in utilizing oil/metal oxide hybrid bionanocomposite, especially organic/ inorganic to design different biomedical applications. The present study reports the synthesis, characterization, antibacterial and anticancer properties of biogenic silver nanoparticles (AgNPs) and L.satiVum oil/PEG/Ag-MgO bionanocomposite. The fabricated AgNPs and L.sativum oil/PEG/Ag-MgO bionanocomposite were characterized by employing different spectroscopic (UV, FTIR, XRD) and microscopic (TEM, SEM) techniques. The particle size analysis showed that the mean size of 16.32 nm for AgNPS and 13.45 nm L.satiVum oil/PEG/Ag-MgO, indicating the excellent dispersion of Ag-MgO nanoparticles in the PEG– L.satiVum oil matrix. The antimicrobial activity of AgNPs and polymeric bionanocomposite was investigated against two pathogenic bacteria. The highest antibacterial effect was observed for bionanocomposite towards Gram-positive Staphylococcus aureus (27 mm) and Gram-negative Escherichia coli (25 mm) at 40 µg/well. The bionanocomposite completely vanished the bacterial growth (100%) at 80 µgmL −1 concentrations. Moreover, the AgNPs and polymeric bionanocomposite was evaluated for anticancer activity against human cervical cancer cells (HeLa cells) at different doses (50, 250, 500, and 1000 µgmL −1 ). The results showed polymeric bionanocomposite was stronger in inducing the HeLa cancer cell death than AgNPs. Overall, the fabricated L.satiVum oil/PEG/Ag-MgO bionanocomposite serve as a potential antimicrobial and anticancer agent and could be used in the development of novel drugs and health care products in near future.

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Bio-nanocomposite IPN for Biomedical Application

Cited by 2 publications

References 110 publications

Tuning Dual-Dynamic Network Materials through Polymer Architectural Features

Tuning Dual-Dynamic Network Materials through Polymer Architectural Features

Prospective of biosynthesized L.satiVum oil/PEG/Ag-MgO bionanocomposite film for its antibacterial and anticancer potential

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