Bio-orthogonal click-targeting nanocomposites for chemo-photothermal synergistic therapy in breast cancer

Qiao, Jianan; Tian, Fengchun; Deng, Ya; Shang, Yunkai; Chen, Shijie; Chang, Enhao; Yao, Jing

doi:10.7150/thno.42445

Cited by 28 publications

(17 citation statements)

References 53 publications

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“…However, long-term application of a single photothermal therapy may cause the overexpression of heat shock protein, leading to the heat tolerance of tumors. Combination therapy, such as chemo-photothermal therapy, is widely used to overcome this obstacle [ 88 – 90 ]. Zhang et al [ 91 ] synthesized PEG (polyethylene glycol)-modified MPDA (MPDA-PEG) via an emulsion-induced interface assembly method.…”

Section: Mesoporous Polydopamine Applications In Tumor Therapymentioning

confidence: 99%

Recent developments in mesoporous polydopamine-derived nanoplatforms for cancer theranostics

et al. 2021

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Polydopamine (PDA), which is derived from marine mussels, has excellent potential in early diagnosis of diseases and targeted drug delivery owing to its good biocompatibility, biodegradability, and photothermal conversion. However, when used as a solid nanoparticle, the application of traditional PDA is restricted because of the low drug-loading and encapsulation efficiencies of hydrophobic drugs. Nevertheless, the emergence of mesoporous materials broaden our horizon. Mesoporous polydopamine (MPDA) has the characteristics of a porous structure, simple preparation process, low cost, high specific surface area, high light-to-heat conversion efficiency, and excellent biocompatibility, and therefore has gained considerable interest. This review provides an overview of the preparation methods and the latest applications of MPDA-based nanodrug delivery systems (chemotherapy combined with radiotherapy, photothermal therapy combined with chemotherapy, photothermal therapy combined with immunotherapy, photothermal therapy combined with photodynamic/chemodynamic therapy, and cancer theranostics). This review is expected to shed light on the multi-strategy antitumor therapy applications of MPDA-based nanodrug delivery systems. Graphical Abstract

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Section: Mesoporous Polydopamine Applications In Tumor Therapymentioning

confidence: 99%

Recent developments in mesoporous polydopamine-derived nanoplatforms for cancer theranostics

et al. 2021

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“…Qiao and co-workers developed a copper-free click-targeting LMWH-quercetin nanocomposite system (DLQ/DZ) that improved the specific co-delivery of doxorubicin and the photosensitizer zinc phthalocyanine (PTT application) against breast cancer cells by glycoengineering the tumor cell surface with an azide-modified sugar (Ac4ManN 3 ) (Figure 25). 223 This co-treatment combination (chemotherapeutic agent and PTT) was studied because it is known that PTT enhances tumor sensitivity to chemotherapeutic agents. The use of artificial receptors and the glycoengineering system necessitated this synergic treatment (with intratumoral rather than intravenous injection of Ac4ManN 3 ).…”

Section: Nps Using Click Chemistry For a Theranostic Approachmentioning

confidence: 99%

Click and Bioorthogonal Chemistry: The Future of Active Targeting of Nanoparticles for Nanomedicines?

et al. 2021

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Over the years, click and bioorthogonal reactions have been the subject of considerable research efforts. These high-performance chemical reactions have been developed to meet requirements not often provided by the chemical reactions commonly used today in the biological environment, such as selectivity, rapid reaction rate and biocompatibility. Click and bioorthogonal reactions have been attracting increasing attention in the biomedical field for the engineering of nanomedicines. In this review, we study a compilation of articles from 2014 to the present, using the terms "click chemistry and nanoparticles (NPs)" to highlight the application of this type of chemistry for applications involving NPs intended for biomedical applications. This study identifies the main strategies offered by click and bioorthogonal chemistry, with respect to passive and active targeting, for NP functionalization with specific and multiple properties for imaging and cancer therapy. In the final part, a novel and promising approach for "two step" targeting of NPs, called pretargeting (PT), is also discussed; the principle of this strategy as well as all the studies listed from 2014 to the present are presented in more detail.

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“…More recently, the team of Yao investigated a similar targeting protocol for the chemo‐photothermal therapy of breast tumours (Figure 15, entry 2) [64] . They developed DBCO‐functionalised nanocomposites designed for the simultaneous delivery of doxorubicin and a photosensitiser (zinc phthalocyanine).…”

Section: In Vivo Bioorthogonal Chemistry For Therapeutic Applicationsmentioning

confidence: 99%

Bioorthogonal Reactions in Animals

et al. 2020

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The advent of bioorthogonal chemistry has led to the development of powerful chemical tools that enable increasingly ambitious applications. In particular, these tools have made it possible to achieve what is considered to be the holy grail of many researchers involved in chemical biology: to perform unnatural chemical reactions within living organisms. In this minireview, we present an update of bioorthogonal reactions that have been carried out in animals for various applications. We outline the advances made in the understanding of fundamental biological processes, and the development of innovative imaging and therapeutic strategies using bioorthogonal chemistry.

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Bio-orthogonal click-targeting nanocomposites for chemo-photothermal synergistic therapy in breast cancer

Cited by 28 publications

References 53 publications

Recent developments in mesoporous polydopamine-derived nanoplatforms for cancer theranostics

Recent developments in mesoporous polydopamine-derived nanoplatforms for cancer theranostics

Click and Bioorthogonal Chemistry: The Future of Active Targeting of Nanoparticles for Nanomedicines?

Bioorthogonal Reactions in Animals

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