Bio-polymeric hydrogels for regeneration of corneal epithelial tissue*

Pourjabbar, Bahareh; Biazar, Esmaeil; Keshel, Saeed Heidari; Ahani-Nahayati, Milad; Baradaran‐Rafii, Alireza; Roozafzoon, Reza; Alemzadeh-Ansari, Mohammad Hasan

doi:10.1080/00914037.2021.1909586

Cited by 5 publications

(9 citation statements)

References 155 publications

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“…The use of Co extracted from marine origin was one of the advantages of this research due to its higher solubility in water and suitable physical properties for designing transparent membranes and, most importantly, excellent cell properties. Transparency is an essential criterion for corneal grafts, and it is connected to Co structure, which contributes to transparency with its water‐retaining proteoglycans 45‐47 . The cornea must effectively transmit incoming light while maintaining its transparency to achieve optimal ocular sharpness 48,49 .…”

Section: Resultsmentioning

confidence: 99%

“…Transparency is an essential criterion for corneal grafts, and it is connected to Co structure, which contributes to transparency with its water‐retaining proteoglycans. 45 , 46 , 47 The cornea must effectively transmit incoming light while maintaining its transparency to achieve optimal ocular sharpness. 48 , 49 Islam et al, developed hydrogels with a thickness of about 500 μm containing interpenetrating networks of recombinant human Co type III/2‐methacryloyloxyethyl phosphorylcholine (RHCIII‐MPC) as a substitute for the corneal ECM to promote endogenous corneal tissue regeneration.…”

Section: Resultsmentioning

confidence: 99%

“…Its bio‐adhesion, biocompatibility, and biodegradability make Co as an excellent candidate for tissue regeneration. It is also the primary component of corneal tissue 20,21 . Fish collagen (FC) can be a great alternative to mammalian Co in tissue engineering applications for reasons such as disease‐free transmission, low immunogenicity, high biodegradability, and good solubility 22,23 .…”

Section: Introductionmentioning

confidence: 99%

“…It is also the primary component of corneal tissue. 20 , 21 Fish collagen (FC) can be a great alternative to mammalian Co in tissue engineering applications for reasons such as disease‐free transmission, low immunogenicity, high biodegradability, and good solubility. 22 , 23 Various methods such as the use of cross linkers or additives have been used to modify the properties of Co, especially its mechanical weakness.…”

Section: Introductionmentioning

confidence: 99%

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Improving the properties of fish skin collagen/silk fibroin dressing by chemical treatment for corneal wound healing

Pourjabbar

Biazar

Keshel

et al. 2022

International Wound Journal

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Natural biomaterials are crucial in ocular tissue engineering because they allow cells to proliferate, differentiate, and stratify while maintaining the typical epithelial phenotype. In this study, membranes as dressings were formed from silk fibroin and collagen (Co) extracted from fish skin and then modified with carbodiimide chemical cross linker in different concentrations. The samples were evaluated by different analyses such as structural, physical (optical, swelling, denaturation temperature, degradation), mechanical, and biological (viability, cell adhesion, immunocytochemistry) assays. The results showed that all membranes have excellent transparency, especially with higher silk fibroin content. Increasing the cross linker concentration and the ratio of silk fibroin to Co increased the denaturation temperature and mechanical strength and, conversely, reduced the degradation rate and cell adhesion. The samples did not show a significant difference in toxicity with increasing cross linker and silk fibroin ratio. In general, samples with a low silk fibroin ratio combined with cross linker can provide desirable properties as a membrane for corneal wound healing.carbodiimide cross linker, cornea wound healing, fish collagen, properties studies, silk fibroin Key Messages• natural biomaterials such as collagen extracted from fish skin and silk fibroin can well be used as dressings to heal wounds

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Improving the properties of fish skin collagen/silk fibroin dressing by chemical treatment for corneal wound healing

Pourjabbar

Biazar

Keshel

et al. 2022

International Wound Journal

Self Cite

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show abstract

“…Hydrogels from natural polymers have attracted research and development attention for a wide range of applications due to their biodegradability, biocompatibility, and ability to mimic living tissues’ characteristics [ 1 , 2 , 3 ]. Among biopolymer-derived hydrogels, gelatin is considered one of the most promising due to its thermoreversible gelling properties, film-forming ability, and processing versatility [ 4 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Role of Sodium Dodecyl Sulfate in Tailoring the Rheological Properties of High-Strength Gelatin Hydrogels

Torrejon

Deng

Luo

et al. 2021

Gels

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Gelatin hydrogels are widely used materials that may require surfactants to adjust their solution’s surface tension for cell attachment, surface adsorption enhancement, or foaming. However, gelatin is a highly surface-active polymer, and its concentrated solutions usually do not require surfactants to achieve low surface tension. However, anionic surfactants, such as sodium dodecyl sulfate (SDS), interact strongly with gelatin to form complexes that impact its hydrogels’ rheological properties, influencing processability and functionality. Nevertheless, there is a lack of systematic research on the impact of these complexes on high gelatin content (i.e., high strength) hydrogels’ rheological properties. In this work, the SDS/gelatin ratio-dependent viscoelastic properties (e.g., gel strength, gelation kinetics, and melting/gelling temperature) of high-strength gelatin hydrogels were investigated using rheology and correlated to surface tension, viscometry, FTIR, and UV-Vis spectrophotometry. SDS–gelatin ratio was proved to be an important factor in tailoring the rheological properties of gelatin hydrogels. The gel strength, gelation kinetics, and melting/gelling temperature of the gelatin hydrogels linearly increased with SDS incorporation up to a maximum value, from which they started to decline. The findings of this work have wide applicability in tailoring the properties of gelatin–SDS solutions and hydrogels during their processing.

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The Design and Developments of Protein‐Polysaccharide Biomaterials for Corneal Tissue Engineering

Prasathkumar

Chenthamara

Lin

et al. 2023

Adv Materials Technologies

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Corneal blindness is explained by a large reduction in vision loss caused by acute and chronic corneal diseases and/or disorders. Due to the severe unavailability of donor corneas, immune rejection, and the side effects of keratoprosthesis (KPro), vision‐impaired patients are often unable to restore their vision. Corneal tissue engineering appears to be a promising method using natural polymers made from different layers of corneal cells such as epithelium, stroma, and endothelium or full tissue equivalents. Proteins and polysaccharides are able to mimic the chemical composition of the native extracellular matrix (ECM), which has been extensively studied for corneal tissue engineering. Additionally, protein‐based materials are highly favored in corneal regenerative therapy as they have the proper cell‐binding sites for cell adhesion, corneal innervation regeneration, and oxidative stress suppression, while polysaccharide‐based materials can also promote cell proliferation and adhesion as well as ocular permeability. Herein, a comprehensive review of various biomaterials based on natural proteins (fibrin, fibrinogen, silk fibroin, collagen, gelatin, and serum albumin) and polysaccharides (chitin, chitosan, hyaluronic acid, alginate, cellulose, and gellan gum) for corneal tissue engineering are provided. The protein‐polysaccharide biomaterials are mainly used in the form of hydrogels, films, scaffolds, sutures, eye drops, nanocarriers, and nanocapsules to treat ocular diseases that cause blindness, such as corneal wounds, corneal ulcers, Goldenhar syndrome, corneal endothelium and stroma defects, corneal neovascularization, etc. In this review, insight is provided into recent developments in the areas of biomaterial design, cross‐linking strategy, corneal cell selection, and frontiers that are expected to offer researchers support and creativity in the development of corneal regenerative medicine.

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Bio-polymeric hydrogels for regeneration of corneal epithelial tissue*

Cited by 5 publications

References 155 publications

Improving the properties of fish skin collagen/silk fibroin dressing by chemical treatment for corneal wound healing

Improving the properties of fish skin collagen/silk fibroin dressing by chemical treatment for corneal wound healing

Role of Sodium Dodecyl Sulfate in Tailoring the Rheological Properties of High-Strength Gelatin Hydrogels

The Design and Developments of Protein‐Polysaccharide Biomaterials for Corneal Tissue Engineering

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