Bio-produced Propionic Acid: A Review

Vidra, Aladár; Németh, Áron

doi:10.3311/ppch.10805

Cited by 27 publications

(19 citation statements)

References 40 publications

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“…The three different biochemical pathways for propionate production include the succinate, acrylate, and propanediol pathways (Reichardt et al, 2014; Vidra & Németh, 2018). Bacteroides spp.…”

Section: Discussionmentioning

confidence: 99%

Microbial interaction between the succinate‐utilizing bacterium Phascolarctobacterium faecium and the gut commensal Bacteroides thetaiotaomicron

et al. 2020

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Section: Discussionmentioning

confidence: 99%

Microbial interaction between the succinate‐utilizing bacterium Phascolarctobacterium faecium and the gut commensal Bacteroides thetaiotaomicron

et al. 2020

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“…We discovered that microorganisms concentrated more energy on butyrate production than acetate production upon SFR, which was also supported by the increased abundances of butyrate-producing bacteria Pseudobutyrivibrio and Papillibacter. Propionate is mainly produced via the succinate pathway (from pyruvate to succinate and then to propionate) and the acrylate pathway (using acrylate and lactate as substrates) [ 30 , 31 ]. We found that propionate production through the acrylate pathway was probably increased while that through the succinate pathway was weakened under SFR condition.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, the enhanced methanogenesis in SFR ewes was in agreement with the report by Goopy et al [ 32 ] who found that severe below-maintenance feed intake increased methane yield in cattle. As well-known that methanogenesis competes the same substrates such as hydrogen with propionate production [ 31 , 33 ]. Thus, the enhanced methanogenesis suggests that malnutrition may exclude propionate-producing functional groups [ 34 – 36 ].…”

Section: Discussionmentioning

confidence: 99%

Disruption of ruminal homeostasis by malnutrition involved in systemic ruminal microbiota-host interactions in a pregnant sheep model

Xue

Lin

et al. 2020

Microbiome

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Background Undernutrition is a prevalent and spontaneous condition in animal production which always affects microbiota-host interaction in gastrointestinal tract. However, how undernutrition affects crosstalk homeostasis is largely unknown. Here, we discover how undernutrition affects microbial profiles and subsequently how microbial metabolism affects the signal transduction and tissue renewal in ruminal epithelium, clarifying the detrimental effect of undernutrition on ruminal homeostasis in a pregnant sheep model. Results Sixteen pregnant ewes (115 days of gestation) were randomly and equally assigned to the control (CON) and severe feed restriction (SFR) groups. Ewes on SFR treatment were restricted to a 30% level of ad libitum feed intake while the controls were fed normally. After 15 days, all ewes were slaughtered to collect ruminal digesta for 16S rRNA gene and metagenomic sequencing and ruminal epithelium for transcriptome sequencing. Results showed that SFR diminished the levels of ruminal volatile fatty acids and microbial proteins and repressed the length, width, and surface area of ruminal papillae. The 16S rRNA gene analysis indicated that SFR altered the relative abundance of ruminal bacterial community, showing decreased bacteria about saccharide degradation (Saccharofermentans and Ruminococcus) and propionate genesis (Succiniclasticum) but increased butyrate producers (Pseudobutyrivibrio and Papillibacter). Metagenome analysis displayed that genes related to amino acid metabolism, acetate genesis, and succinate-pathway propionate production were downregulated upon SFR, while genes involved in butyrate and methane genesis and acrylate-pathway propionate production were upregulated. Transcriptome and real-time PCR analysis of ruminal epithelium showed that downregulated collagen synthesis upon SFR lowered extracellular matrix-receptor interaction, inactivated JAK3-STAT2 signaling pathway, and inhibited DNA replication and cell cycle. Conclusions Generally, undernutrition altered rumen bacterial community and function profile to decrease ruminal energy retention, promoted epithelial glucose and fatty acid catabolism to elevate energy supply, and inhibited the proliferation of ruminal epithelial cells. These findings provide the first insight into the systemic microbiota-host interactions that are involved in disrupting the ruminal homeostasis under a malnutrition pattern.

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“…For industrial purposes, propionate is synthesized by petrochemical means—Reppe and Larson processes. The Reppe process involves the conversion of ethylene, carbon monoxide, and steam into propionic acid, while in the Larson process, propionic acid is produced from ethanol and carbon monoxide in the presence of a catalyst (boron trifluoride) [ 2 , 3 ]. Propionic acid is used primarily in the food and feed industry as a preservative for inhibiting the growth of yeasts and molds.…”

Section: Introductionmentioning

confidence: 99%

Use of Propionibacterium freudenreichii T82 Strain for Effective Biosynthesis of Propionic Acid and Trehalose in a Medium with Apple Pomace Extract and Potato Wastewater

et al. 2021

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Propionic acid bacteria are the source of many metabolites, e.g., propionic acid and trehalose. Compared to microbiological synthesis, the production of these metabolites by petrochemical means or enzymatic conversion is more profitable. The components of microbiological media account for a large part of the costs associated with propionic fermentation, due to the high nutritional requirements of Propionibacterium. This problem can be overcome by formulating a medium based on the by-products of technological processes, which can act as nutritional sources and at the same time replace expensive laboratory preparations (e.g., peptone and yeast extract). The metabolic activity of P. freudenreichii was investigated in two different breeding environments: in a medium containing peptone, yeast extract, and biotin, and in a waste-based medium consisting of only apple pomace and potato wastewater. The highest production of propionic acid amounting to 14.54 g/L was obtained in the medium containing apple pomace and pure laboratory supplements with a yield of 0.44 g/g. Importantly, the acid production parameters in the waste medium reached almost the same level (12.71 g/L, 0.42 g/g) as the medium containing pure supplements. Acetic acid synthesis was more efficient in the waste medium; it was also characterized by a higher level of accumulated trehalose (59.8 mg/g d.s.). Thus, the obtained results show that P. freudenreichii bacteria exhibited relatively high metabolic activity in an environment with apple pomace used as a carbon source and potato wastewater used as a nitrogen source. This method of propioniate production could be cheaper and more sustainable than the chemical manner.

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Bio-produced Propionic Acid: A Review

Abstract: Abstract

Cited by 27 publications

References 40 publications

Microbial interaction between the succinate‐utilizing bacterium Phascolarctobacterium faecium and the gut commensal Bacteroides thetaiotaomicron

Microbial interaction between the succinate‐utilizing bacterium Phascolarctobacterium faecium and the gut commensal Bacteroides thetaiotaomicron

Disruption of ruminal homeostasis by malnutrition involved in systemic ruminal microbiota-host interactions in a pregnant sheep model

Use of Propionibacterium freudenreichii T82 Strain for Effective Biosynthesis of Propionic Acid and Trehalose in a Medium with Apple Pomace Extract and Potato Wastewater

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