Bio-psycho-soziale Charakteristika und therapeutische Aspekte bei Methamphetamin-abhängigen Frauen – Gendersensible Ergebnisse einer systematischen Literaturrecherche

Abstract

In women, abuse and dependence of MethA are determined by psychological as well as social factors. However, further research is needed to improve prevention, counseling and therapy.

Adults With Opioid and Methamphetamine Co-use Have Lower Odds of Completing Short-Term Residential Treatment Than Other Opioid Co-use Groups: A Retrospective Health Services Study

“…A review of the literature found that women start using methamphetamine at an earlier age and are more dependent on methamphetamine than men ( 29 ). Among reproductive age and pregnant women, methamphetamine is one of the most abused substances ( 30 , 31 ). A study based on persons who inject drugs in Seattle found a higher proportion of women co-using heroin and amphetamine instead of using these substances alone ( 32 ).…”

Sex differences in methamphetamine use disorder perused from pre-clinical and clinical studies: Potential therapeutic impacts

“…In general, humans who carry a MUD diagnosis suffer from cognitive deficits that appear to be related to METH-induced neuropathological abnormalities that include biochemical and structural changes in the brain ( Bae et al, 2006 ; Cadet and Bisagno, 2015 ; Cadet et al, 2014 ; Chang et al, 2002 ; Cloak et al, 2011 ; Hall et al, 2015 ; Heinzerling et al, 2016 ; Heinzerling and Shoptaw, 2012 ; Johnson et al, 2010 ; Kim et al, 2005 ; King et al, 2010a ; Kishi et al, 2011 ; Kogachi et al, 2017 ; Koizumi et al, 2004 ; Lin et al, 2003 ; Nakatome et al, 2009 ; Nie et al, 2021 ; O’Neill et al, 2014 ; Sung et al, 2013 ; Tang et al, 2019 ; Tobias et al, 2010 ). Related to the theme of this review, however, METH-induced neuropsychiatric complications have been reported to be more common in women than men ( Lisa et al, 2019 ; Mihan et al, 2018 ; Neumann et al, 2018 ) (see Fig. 3 ).…”

“…METH use disorder is a neuropsychiatric disorder that impacts both male and female users negatively ( Cservenka and Ray, 2017 ; Darke et al, 2011 ; DiMiceli et al, 2016 ; Han et al, 2016 ; He et al, 2020 ; Lisa et al, 2019 ; Mayo et al, 2019 ; McKetin et al, 2011 ; Mihan et al, 2018 ; Neumann et al, 2018 ; Polcin et al, 2012 ; Su et al, 2017 ; Zhao et al, 2021b ). In general, humans who carry a MUD diagnosis suffer from cognitive deficits that appear to be related to METH-induced neuropathological abnormalities that include biochemical and structural changes in the brain ( Bae et al, 2006 ; Cadet and Bisagno, 2015 ; Cadet et al, 2014 ; Chang et al, 2002 ; Cloak et al, 2011 ; Hall et al, 2015 ; Heinzerling et al, 2016 ; Heinzerling and Shoptaw, 2012 ; Johnson et al, 2010 ; Kim et al, 2005 ; King et al, 2010a ; Kishi et al, 2011 ; Kogachi et al, 2017 ; Koizumi et al, 2004 ; Lin et al, 2003 ; Nakatome et al, 2009 ; Nie et al, 2021 ; O’Neill et al, 2014 ; Sung et al, 2013 ; Tang et al, 2019 ; Tobias et al, 2010 ).…”

“…Female subjects during withdrawal reported more olfactory and tactile hallucinations as well as paranoid delusions ( Mahoney et al, 2010 , 2008 ). METH-induced cognitive disorders appear to also be more pronounced in women than in men ( Neumann et al, 2018 ). Specifically, women with MUD showed severe impairments in decision-making ( van der Plas et al, 2009 ), concentration, and learning and memory ( Han et al, 2016 ).…”

“…As discussed above, clinical studies have reported that female METH users appear to suffer from severe neuropsychiatric complications ( Lisa et al, 2019 ; Mihan et al, 2018 ; Neumann et al, 2018 ), whereas some pre-clinical animal models appear to offer equivocal results. These issues are probably related to the fact that it is not possible to recreate the complexity of human conditions in rodents and, even, in non-human primates.…”