(Bio)sensors applied to coral reefs’ health monitoring: a critical overview

Gastoldi, Lucia; Cinti, Stefano

doi:10.1016/j.greeac.2023.100049

Cited by 4 publications

(3 citation statements)

References 220 publications

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“…SPEs have been widely applied to analyse many analytes in all existing fields of relevance, such as clinical, environmental, pharmaceutical, agri‐food, etc [26–31] . However, the choice of the substrate where the SPEs are realised is not always fixed and might depend on the features that are required, i. e. flexibility, mechanical strength, robustness, cost, disposability, etc.…”

Section: Resultsmentioning

confidence: 99%

“…SPEs have been widely applied to analyse many analytes in all existing fields of relevance, such as clinical, environmental, pharmaceutical, agri-food, etc. [26][27][28][29][30][31] However, the choice of the substrate where the SPEs are realised is not always fixed and might depend on the features that are required, i. e. flexibility, mechanical strength, robustness, cost, disposability, etc. For this reason, the first characterisation has focused on the electrochemical evaluation in the presence of an electrochemical mediator, namely potassium ferricyanide, and in the presence of sulfuric acid, as reported in Figure 2.…”

Section: Electrochemical Characterization Of Spesmentioning

confidence: 99%

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Electrochemical detection of miRNA using commercial and hand‐made screen‐printed electrodes: liquid biopsy for cancer management as case of study

Raucci,

Cimmino,

Romanò

et al. 2024

ChemistryOpen

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The growth of liquid biopsy, i. e., the possibility of obtaining health information by analysing circulating species (nucleic acids, cells, proteins, and vesicles) in peripheric biofluids, is pushing the field of sensors and biosensors beyond the limit to provide decentralised solutions for nonspecialists. In particular, among all the circulating species that can be adopted in managing cancer evolution, both for diagnostic and prognostic applications, microRNAs have been highly studied and detected. The development of electrochemical devices is particularly relevant for liquid biopsy purposes, and the screen‐printed electrodes (SPEs) represent one of the building blocks for producing novel portable devices. In this work, we have taken miR‐2115‐3p as model target (it is related to lung cancer), and we have developed a biosensor by exploiting the use of a complementary DNA probe modified with methylene blue as redox mediator. In particular, the chosen sensing architecture was applied to serum measurements of the selected miRNA, obtaining a detection limit within the low nanomolar range; in addition, various platforms were interrogated, namely commercial and hand‐made SPEs, with the aim of providing the reader with some insights about the optimal platform to be used by considering both the cost and the analytical performance.

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Section: Resultsmentioning

confidence: 99%

Section: Electrochemical Characterization Of Spesmentioning

confidence: 99%

Electrochemical detection of miRNA using commercial and hand‐made screen‐printed electrodes: liquid biopsy for cancer management as case of study

Raucci,

Cimmino,

Romanò

et al. 2024

ChemistryOpen

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“…These techniques represent the gold standard in analytical chemistry, but require instruments of large size and weight, long time, and effort for sample preparation and analysis, and often involve the use of advanced equipment and modern clean rooms. For all these aspects, these techniques are unsuitable for in situ real-time analytical detection, especially in remote locations and in space, where reduced footprint and payload are key requirements ( Clatterbaugh et al, 2010 ; Gastoldi and Cinti, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Reviewing the state of biosensors and lab-on-a- chip technologies: opportunities for extreme environments and space exploration

Cinti,

Singh,

Covone

et al. 2023

Front. Microbiol.

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The space race is entering a new era of exploration, in which the number of robotic and human missions to various places in our solar system is rapidly increasing. Despite the recent advances in propulsion and life support technologies, there is a growing need to perform analytical measurements and laboratory experiments across diverse domains of science, while keeping low payload requirements. In this context, lab-on-a-chip nanobiosensors appear to be an emerging technology capable of revolutionizing space exploration, given their low footprint, high accuracy, and low payload requirements. To date, only some approaches for monitoring astronaut health in spacecraft environments have been reported. Although non-invasive molecular diagnostics, like lab-on-a-chip technology, are expected to improve the quality of long-term space missions, their application to monitor microbiological and environmental variables is rarely reported, even for analogous extreme environments on Earth. The possibility of evaluating the occurrence of unknown or unexpected species, identifying redox gradients relevant to microbial metabolism, or testing for specific possible biosignatures, will play a key role in the future of space microbiology. In this review, we will examine the current and potential roles of lab-on-a-chip technology in space exploration and in extreme environment investigation, reporting what has been tested so far, and clarifying the direction toward which the newly developed technologies of portable lab-on-a-chip sensors are heading for exploration in extreme environments and in space.

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