Bio-templated bioactive glass particles with hierarchical macro–nano porous structure and drug delivery capability

Zheng, Kai; Bortuzzo, Judith A.; Liu, Yufang; Li, Wei; Pischetsrieder, Monika; Roether, Judith A.; Lü, Miao; Boccaccını, Aldo R.

doi:10.1016/j.colsurfb.2015.03.038

Cited by 33 publications

(19 citation statements)

References 57 publications

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“…17,35 Briey, BGN-30 particles were immersed in simulated body uid (SBF) in an incubator (KS 4000i control, IKA, Germany) at 37 C and 120 rpm for up to 7 days. SBF was replaced twice per week to keep the ion concentration stable.…”

Section: In Vitro Mineralizationmentioning

confidence: 99%

“…Organic templates were also used to assist the synthesis of BG particles, but the dispersity and size homogeneity still need improvement. [16][17][18] The Stöber method is convenient to produce monodispersed spherical silica-based nanoparticles in a range of 100-1000 nm. [19][20][21] This method is performed under highly basic conditions, thus the formed nanoparticles could maintain dispersion due to the charge repulsion between the particles.…”

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confidence: 99%

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Timing of calcium nitrate addition affects morphology, dispersity and composition of bioactive glass nanoparticles

et al. 2016

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Bioactive glass nanoparticles (BGN) are promising materials for a number of biomedical applications. Many parameters related to the synthesis of BGN using sol-gel methods can affect their characteristics. In this study, the influence of timing of calcium nitrate (calcium precursor) addition during processing on BGN characteristics was investigated. The results showed that the addition timing could affect the morphology, dispersity and composition of BGN. With delayed addition of calcium nitrate, larger, more regular and better dispersed BGN could be synthesized while the gap between nominal and actual compositions of BGN was widened. However, the addition timing had no significant influence on structural characteristics, as BGN with different addition-timing of calcium nitrate exhibited similar infrared spectra and amorphous nature. The results also suggested that monodispersed BGN could be synthesized by carefully controlling the addition of calcium nitrate. The synthesized monodispersed BGN could release Si and Ca ions continuously for up to at least 14 days. They also showed in vitro bioactivity and non-cytotoxicity towards rat bone marrow-derived mesenchymal stem cells (rBMSCs). In conclusion, the timing of calcium precursor addition is an essential parameter to be considered when producing BGN which should exhibit monodisperse characteristics for biomedical applications.

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Section: In Vitro Mineralizationmentioning

confidence: 99%

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confidence: 99%

Timing of calcium nitrate addition affects morphology, dispersity and composition of bioactive glass nanoparticles

et al. 2016

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“…; Zheng et al . ). The surface area and porosity determine the drug‐loading capacity (Cavalu et al .…”

Section: Bioactive Glasses As Biomaterials Delivery Systems For Antimimentioning

confidence: 97%

“…Based on the fact that sol‐gel‐derived BGs are intrinsically nanoporous and have a high surface area, which allows loading biomolecules (Zheng et al . ), the loading of tetracycline hydrochloride (THC) to sol‐gel particles has been extensively studied (Domingues et al . ; Andrade et al .…”

Section: Bioactive Glasses As Biomaterials Delivery Systems For Antimimentioning

confidence: 99%

Bioactive glasses as delivery systems for antimicrobial agents

Rivadeneira

Gorustovich

2017

J Appl Microbiol

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Summary Most biomaterial‐associated infections are caused by opportunistic pathogens and bacteria that are regularly found within the microflora of the implant site. In addition, a biomaterial implant or device remains at risk of infection by hematogenous spread of bacteria disseminated from infections elsewhere in the body or from infected peri‐implant tissue in revision surgery. The resulting infections are frequently accompanied by patient morbidity and discomfort and can lead to surgical replacement of the implant after lengthy, unsuccessful attempts to mitigate infections with antibiotic treatments. Therefore, extensive study is aiming to find new infection‐resistant antimicrobial biomaterials and coatings for implants and devices to effectively reduce the incidence of biomaterial‐associated infections. An overview of the in vitro and in vivo antimicrobial efficacies of the numerous biomaterials currently available is beyond the scope of this review. Herein, we provide a comprehensive review of bioactive glasses as biomaterial delivery systems for antimicrobial agents.

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“…The synthesis of inorganic materials with well-defined architectures based on the construction of nanounits (nanowires, nanosheets, nanoneedles, nanobelts or nanotubes) has gained considerable attention over the past years, owing to their importance in basic scientific research and potential technological applications [1,2]. Calcium carbonate is an important mineral material due to its significance as a biomineral and to widely industrial applications for plastics, rubbers, papermaking, biomedical implant, drug delivery, and water treatment [3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Preparation of mesoporous calcite with hierarchical architectures

Yao

et al. 2015

Materials Letters

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Bio-templated bioactive glass particles with hierarchical macro–nano porous structure and drug delivery capability

Cited by 33 publications

References 57 publications

Timing of calcium nitrate addition affects morphology, dispersity and composition of bioactive glass nanoparticles

Timing of calcium nitrate addition affects morphology, dispersity and composition of bioactive glass nanoparticles

Bioactive glasses as delivery systems for antimicrobial agents

Preparation of mesoporous calcite with hierarchical architectures

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