Bioabsorbable polymer scaffolds for tissue engineering capable of sustained growth factor delivery

Sheridan, M.H; Shea, Lonnie D.; Peters, Martin C.; Mooney, David J.

doi:10.1016/s0168-3659(99)00138-8

Cited by 480 publications

(323 citation statements)

References 31 publications

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“…However, when implanting cells/scaffolds into root canals that have blood supply only from the apical end, enhanced vascularization is needed in order to support the vitality of the implanted cells in the scaffolds. Recent efforts in developing scaffold systems for tissue engineering have been focusing on creating a system that promotes angiogenesis for the formation of a vascular network (51)(52)(53)(54)(55)(56). These scaffolds are impregnated with growth factors such as VEGF and/or platelet-derived growth factor or, further, with the addition of endothelial cells.…”

Section: Stem Cells For Pulp/dentin Tissue Engineering and Regenerationmentioning

confidence: 99%

The Hidden Treasure in Apical Papilla: The Potential Role in Pulp/Dentin Regeneration and BioRoot Engineering

Huang

Sonoyama

Liu

et al. 2008

Journal of Endodontics

656

543

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Some clinical case reports have shown that immature permanent teeth with periradicular periodontitis or abscess can undergo apexogenesis after conservative endodontic treatment. A call for a paradigm shift and new protocol for the clinical management of these cases has been brought to attention. Concomitantly, a new population of mesenchymal stem cells residing in the apical papilla of permanent immature teeth recently has been discovered and was termed stem cells from the apical papilla (SCAP). These stem cells appear to be the source of odontoblasts that are responsible for the formation of root dentin. Conservation of these stem cells when treating immature teeth may allow continuous formation of the root to completion. This article reviews current findings on the isolation and characterization of these stem cells. The potential role of these stem cells in the following respects will be discussed: (1) their contribution in continued root maturation in endodontically treated immature teeth with periradicular periodontitis or abscess and (2) their potential utilization for pulp/ dentin regeneration and bioroot engineering. KeywordsApexogenesis; apical papilla; bioroot engineering; dental pulp stem cells; immature teeth; periodontal ligament stem cells; pulp regeneration; stem cells from human exfoliated deciduous teeth; stem cells from the apical papilla A number of recent clinical case reports have revealed the possibilities that many teeth that traditionally would receive apexification may be treated for apexogenesis. A call for a paradigm shift and new protocol for the clinical management of these cases has been made by the authors (1-3). A recent scientific finding, which may explain in part why apexogenesis can occur in these infected immature permanent teeth, is the discovery and isolation of a new population of mesenchymal stem cells (MSCs) residing in the apical papilla of incompletely developed teeth (4,5). These cells are termed stem cells from the apical papilla (SCAP), and they differentiate

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Section: Stem Cells For Pulp/dentin Tissue Engineering and Regenerationmentioning

confidence: 99%

The Hidden Treasure in Apical Papilla: The Potential Role in Pulp/Dentin Regeneration and BioRoot Engineering

Huang

Sonoyama

Liu

et al. 2008

Journal of Endodontics

656

543

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“…An overall rating was obtained using weighting factors (53 for the capsular thickness, 33 for the cellular response observed in the capsule, 53 for the neutrophils, 23 for the FBGCs, 13 for the lymphocytes, 13 for macrophages, and 13 for the fibroblasts). Reactions were classified into 6 categories, which were as follows: no reaction (0), minimal (1-10), slight (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25), moderate (26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40), marked (41-60), and excessive (>60).…”

Section: Histological Evaluationmentioning

confidence: 99%

Repair of critical size defects in the rat cranium using ceramic‐reinforced PLA scaffolds obtained by supercritical gas foaming

Montjovent

Mathieu

Schmoekel

et al. 2007

J Biomedical Materials Res

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Bioresorbable scaffolds made of poly(L-lactic acid) (PLA) obtained by supercritical gas foaming were recently described as suitable for tissue engineering, portraying biocompatibility with primary osteoblasts in vitro and interesting mechanical properties when reinforced with ceramics. The behavior of such constructs remained to be evaluated in vivo and therefore the present study was undertaken to compare different PLA/ceramic composite scaffolds obtained by supercritical gas foaming in a critical size defect craniotomy model in Sprague-Dawley rats. The host-tissue reaction to the implants was evaluated semiquantitatively and similar tendencies were noted for all graft substitutes: initially highly reactive but decreasing with time implanted. Complete bonebridging was observed 18 weeks after implantation with PLA/ 5 wt % b-TCP (PLA/TCP) and PLA/5 wt % HA (PLA/HA) scaffolds as assessed by histology and radiography. We show here for the first time that this solvent-free technique provides a promising approach in tissue engineering demonstrating both the biocompatibility and osteoconductivity of the processed structures in vivo.

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“…Using CO 2 to prepare biodegradable polymer foams has been done for poly(lactic-co-glycolic acid), 24 -26 poly(ε-caprolactone), 27,28 poly(L-lactic acid) (PLLA), 11,26,27 poly(glycolic acid), 26,27 PLA, 29 PLA/silk composites 30 and PLA/layered silicate nanocomposites. 31,32 Studies have also demonstrated that CO 2 is able to depress T g and T m , 33,34 and induce crystallization 11 in PLLA.…”

Section: Introductionmentioning

confidence: 99%

Carbon dioxide‐induced crystallization in poly(L‐lactic acid) and its effect on foam morphologies

Liao

Nawaby

Whitfield

2010

Polymer International

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The effect of carbon dioxide (CO2) on the physical properties of poly(L‐lactic acid) (PLLA) and on the formation of crystalline domains was investigated. The presence of CO2 in the matrix was found to induce crystallization in PLLA, with the crystallinity increasing with increasing CO2 pressure. The combination of saturation conditions and formation of crystalline domains was studied for its effect on the formation of porous morphologies in PLLA. Moreover, the effect of CO2 on PLLA properties and formation of porous structures was further exploited by first creating crystalline domains in samples using CO2 at various pressures at 25 °C and then re‐saturating the same samples with CO2 at a constant pressure of 2.8 MPa and 0 °C. This paper reports on the solubility of CO2 at 25 and 0 °C in PLLA, crystallization and subsequent effect on foam morphologies when processed using different saturation cycles. Unique and intriguing morphologies were obtained by specifically controlling the properties of PLLA. Copyright © 2010 Crown in the right of Canada. Published by John Wiley & Sons, Ltd

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Bioabsorbable polymer scaffolds for tissue engineering capable of sustained growth factor delivery

Cited by 480 publications

References 31 publications

The Hidden Treasure in Apical Papilla: The Potential Role in Pulp/Dentin Regeneration and BioRoot Engineering

The Hidden Treasure in Apical Papilla: The Potential Role in Pulp/Dentin Regeneration and BioRoot Engineering

Repair of critical size defects in the rat cranium using ceramic‐reinforced PLA scaffolds obtained by supercritical gas foaming

Carbon dioxide‐induced crystallization in poly(L‐lactic acid) and its effect on foam morphologies

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