Bioabsorbable radiopaque water-responsive shape memory embolization plug for temporary vascular occlusion

Wong, Yuk Shan; Salvekar, Abhijit Vijay; Zhuang, Kun; Birch, William R.; Tay, Kiang Hiong; Huang, Wei; Venkatraman, Subbu S.

doi:10.1016/j.biomaterials.2016.06.014

Cited by 82 publications

(73 citation statements)

References 26 publications

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“…The phenomenon of the SME provides an additional dimension to reshape product design in many ways [6,21,22]. We have seen more and more applications of shape memory polymers (SMPs) in recent years [23][24][25][26][27][28][29][30].…”

Section: Introductionmentioning

confidence: 99%

Influence of Long-Term Storage on Shape Memory Performance and Mechanical Behavior of Pre-stretched Commercial Poly(methyl methacrylate) (PMMA)

et al. 2019

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In this paper, we experimentally investigate the influence of storage at 40 • C on the shape memory performance and mechanical behavior of a pre-stretched commercial poly(methyl methacrylate) (PMMA). This is to simulate the scenario in many applications. Although this is a very important topic in engineering practice, it has rarely been touched upon so far. The shape memory performance is characterized in terms of the shape fixity ratio (after up to one year of storage) and shape recovery ratio (upon heating to previous programming temperature). Programming in the mode of uniaxial tension is carried out at a temperature within the glass transition range to one of four prescribed programming strains (namely 10%, 20%, 40% and 80%). Also investigated is the residual strain after heating for shape recovery. The characterization of the mechanical behavior of programmed samples after storage for up to three months is via cyclic uniaxial tensile test. It is concluded that from an engineering application point view, for this particular PMMA, programming should be done at higher temperatures (i.e., above its T g of 110 • C) in order to not only achieve reliable and better shape memory performance, but also minimize the influence of storage on the shape memory performance and mechanical behavior of the programmed material. This finding provides a useful guide for engineering applications of shape memory polymers, in particular based on the multiple-shape memory effect, temperature memory effect, and/or low temperature programming.2 of 12 applications [34][35][36][37][38][39][40], activation of the SME may not be carried out right after programming, but after a period of storage. As such, we need to consider the influence of aging at around room temperature after programming [41], which is a topic that has been less explored so far [42,43], but that is utterly important from an engineering application point of view.The purpose of this paper is to experimentally investigate the influence of storage at 40 • C on the shape memory performance and mechanical behavior of a commercial poly(methyl methacrylate) (PMMA), which is a typical engineering polymer, used in many applications, including optical lens [44,45] and plastic screw. This particular PMMA has been verified to have excellent heating-responsive SME in our previous studies (e.g., in [46,47]), and unlike some moisture/water-responsive SMPs (e.g., the polyurethane reported in [48]), it appears to be non-sensitive to moisture in air. PMMA and polycarbonates (PC) are typical amorphous polymer, and their SME was reported over 20 years ago [49,50]. Both experimental investigation and simulation on the SME of amorphous polymers (without chemical cross-linking, but via physical cross-linking) have been well documented in the literature (e.g., in [41,51-53]). Different programming temperatures (all within the glass transition range) and programming strains (up to 80%, in the mode of uniaxial tension) are applied in this study, as they have been identified to be influential para...

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Section: Introductionmentioning

confidence: 99%

Influence of Long-Term Storage on Shape Memory Performance and Mechanical Behavior of Pre-stretched Commercial Poly(methyl methacrylate) (PMMA)

et al. 2019

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“…These actuators could convert the chemical potential energy into mechanical work. And water‐responsive shape memory materials such as the water‐triggered shape memory polyurethanes40,41 and water‐responsive embolization plug for temporary vascular occlusion42,43 were also prepared and studied. However, the slow response speed and the small and uncontrolled deformation still restrict the applications of water‐responsive polymer actuators.…”

Section: Introductionmentioning

confidence: 99%

Pre‐Stretched Double Network Polymer Films Based on Agarose and Polyacrylamide with Sensitive Humidity‐Responsive Deformation, Shape Memory, and Self‐Healing Properties

Zhang

Zhou

Zhang

et al. 2020

Macro Chemistry & Physics

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A series of pre‐stretched double network (DN) polymer films based on agarose and polyacrylamide (Agar/PAM) are prepared. These films show the rapid and large deformation in response to humidity due to the release of contraction stress. The pre‐stretched dry film can curl toward the humidity direction into a scroll‐like structure in an extremely short time. The deformation direction can be also well controlled by the stretching direction. The released contraction stress increases with the increase of tensile strain. The DN Agar/PAM hydrogel film shows good water‐induced shape memory effect. It can be stretched to form various temporary shapes such as circle, square, and spiral. The shape fixing and recovery ratios are both close to 100%. The released large contraction stress accelerates the shape recovery process. The recovery time increases with the increase of film thickness. The DN dry film shows the good water‐induced self‐healing ability. The healed film maintains about 88% tensile strength (103 MPa) of the original film. Due to these good properties, the pre‐stretched DN dry films can be fabricated into a soft robot jack which can easily lift up to ≈20 times its own weight within 8 s.

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“…However, the recovery ratio is relatively low, and the recovery temperature is too high for the use in human body . Copolymerization of LLA with other lactones and cyclic carbonates, such as ε‐CL or TMC, is a strategy to decrease the glass transition temperature of PLLA and, as a consequence, to lower the recovery temperature of the material in shape memory applications . Additionally, incorporation of these monomers results in the composition, and properties of the shape memory polymers vary in a wide range.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and properties of shape memory polymers of LLA, TMC, and ε‐CL terpolymers

2019

Polymers for Advanced Techs

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Biodegradable polylactide (PLA) and its copolymers with shape memory properties have attracted great interests because of their important application prospects in biomedical field. In this study, random poly(L-lactide-co-trimethylene carbonate-coε-caprolactone) (LTCL) terpolymers with different molar ratio were synthesized and characterized. Monomer ε-caprolactone (ε-CL) was used in this study instead of glycolide in preliminary study of LTG terpolymers to investigate the transition temperature and the shape memory performance. Characterization on crystallization, mechanical properties, shape fixing, and recovery ratios of the terpolymers was conducted to investigate the correlation between crystallization and shape memory performance of LTCL terpolymers. The results are consistent with the formation of crystallized LLA segments, which could act as crosslinks, strengthened the stationary phase within the polymer matrix, and significantly improved the shape memory performance of LTCL terpolymers. For example, LTCL801010 is a crystalline polymer with high shape fixity and shape recovery ratio; its shape recovery temperature is 39 C. LTCL terpolymers with high CL content do not show shape memory performance for the rubbery at room temperature. Based on this study, PLA materials with shape memory property can be designed through the selection of monomers or the adjustment of comonomer ratio. These polymers with recovery temperature close to 37 C are expected to be used in human body such as scaffolds in tissue engineering. K E Y W O R D SL-lactide, shape memory, trimethylene carbonate, ε-Caprolactone, terpolymer

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Bioabsorbable radiopaque water-responsive shape memory embolization plug for temporary vascular occlusion

Cited by 82 publications

References 26 publications

Influence of Long-Term Storage on Shape Memory Performance and Mechanical Behavior of Pre-stretched Commercial Poly(methyl methacrylate) (PMMA)

Influence of Long-Term Storage on Shape Memory Performance and Mechanical Behavior of Pre-stretched Commercial Poly(methyl methacrylate) (PMMA)

Pre‐Stretched Double Network Polymer Films Based on Agarose and Polyacrylamide with Sensitive Humidity‐Responsive Deformation, Shape Memory, and Self‐Healing Properties

Synthesis and properties of shape memory polymers of LLA, TMC, and ε‐CL terpolymers

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