Bioaccessibility of metal(loid)s in soils to humans and their bioavailability to snails: A way to associate human health and ecotoxicological risk assessment?

Louzon, Maxime; Pelfrêne, Aurélie; Pauget, Benjamin; Gimbert, Frédéric; Morin‐Crini, Nadia; Douay, Francis; Vaufleury, Annette de

doi:10.1016/j.jhazmat.2019.121432

Cited by 21 publications

(4 citation statements)

References 43 publications

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“…The present refined evaluation of food exposure levels for human health risk assessment (HHRA) could further extend to perchlorate-contaminated soil exposure levels for environmental risk assessment (ERA). The integration of HHRA and ERA may contribute to the better management of perchlorate pollution in the frame of the One Health concept. , …”

Section: Results and Discussionmentioning

confidence: 99%

“…The integration of HHRA and ERA may contribute to the better management of perchlorate pollution in the frame of the One Health concept. 15,44 In this study, the bioavailability of perchlorate in the presence of different foods was assessed in an in vivo mouse model. Food matrices and nutritional contents (moisture, dietary fiber, and fat) significantly affected perchlorate bioavailability.…”

Section: 3mentioning

confidence: 99%

“…In real scenarios, the contaminants distributed in food or environmental matrices are not 100% released and absorbed across the gastrointestinal barrier, which are available for systemic distribution, metabolism, and generation of adverse effects. Currently, bioavailability, in the context of human health risk assessment, has been gradually regarded as a critical parameter to decrease the uncertainty in contaminant exposure estimation. − This adjustment or correction factor has been extensively tested for numerous organic or inorganic environmental pollutants, such as dioxin-like compounds, polybrominated diphenyl ethers, perfluorooctanoic acid, organochlorine pesticides, polycyclic aromatic hydrocarbons, and heavy metals. − Bioaccessibility and bioavailability of perchlorate have also been preliminarily investigated in our study in in vitro models, and the results indicated that these two critical parameters could be affected by digestion phases and food matrices. These findings warranted further confirmation in an in vivo model, and the suitability of in vitro data for estimating in vivo bioavailability required investigation through an in vivo – in vitro correlation analysis.…”

Section: Introductionmentioning

confidence: 99%

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Bioavailability Evaluation of Perchlorate in Different Foods In Vivo: Comparison with In Vitro Assays and Implications for Human Health Risk Assessment

Liu

Zhang

Yimei

et al. 2021

J. Agric. Food Chem.

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Perchlorate in various foods continuously arouses public health concern. Bioavailability is a critical parameter to better estimate perchlorate exposure from diets. In this study, perchlorate bioavailability in five foods was determined in an in vivo mouse model and compared with in vitro bioaccessibility/bioavailability. The estimated in vivo perchlorate bioavailability for different foods ranged from 18.01 ± 4.53% to 45.60 ± 7.11%, with the order lettuce > pork > rice > milk powder > soybean. Moisture, fiber, and fat in foods were identified as critical factors affecting perchlorate bioavailability (correlation r = 0.71, 0.52, and −0.67, respectively). Linear regression analysis revealed that the in vitro perchlorate bioavailability determined using the Caco-2 cell model has the potential to estimate the in vivo perchlorate bioavailability in foods (R 2 = 0.67, slope = 1.33, and y intercept = 4.99). These findings provide insights into the effects of the food matrices on perchlorate bioavailability and could contribute to decrease the uncertainty regarding perchlorate dietary exposure risk assessment.

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Section: Results and Discussionmentioning

confidence: 99%

Section: 3mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Bioavailability Evaluation of Perchlorate in Different Foods In Vivo: Comparison with In Vitro Assays and Implications for Human Health Risk Assessment

Liu

Zhang

Yimei

et al. 2021

J. Agric. Food Chem.

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“…Like other soil invertebrates (e.g. Collembola, earthworms, enchytraeids, nematodes, and isopods), snails can be used as model for soil monitoring and ecotoxicity tests (Gomot-De Vaufleury et al 1989;Gomot-De Vaufleury 2000;Scheifler et al 2002;Regoli et al 2006;Fritsch et al 2011;Gomot-De Vaufleury et al 2015;Louzon et al 2020a, b) to determine the toxicity of pollutants (Van Gestel 2012). Gastropods of the genus Helix are macro concentrators for several metals (Dallinger 1993).…”

Section: Introductionmentioning

confidence: 99%

Dose-dependent effects of lead and cadmium and the influence of soil properties on their uptake by Helix aspersa: an ecotoxicity test approach

et al. 2021

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In situ and ex situ bioassays with Cantareus aspersus for environmental risk assessment of metal(loid) and PAH‐contaminated soils

Louzon

Pauget²,

Gimbert

et al. 2021

Integr Envir Assess & Manag

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Environmental risk assessment of contaminated soils requires bioindicators that allow the assessment of bioavailability and toxicity of chemicals. Although many bioassays can determine the ecotoxicity of soil samples in the laboratory, few are available and standardized for on-site application. Bioassays based on specific threshold values that assess the in situ and ex situ bioavailability and risk of metal(loid)s and polycyclic aromatic hydrocarbons (PAHs) in soils to the land snail Cantareus aspersus have never been simultaneously applied to the same soils. The aims of this study were to compare the results provided by in situ and ex situ bioassays and to determine their respective importance for environmental risk assessment. The feasibility and reproducibility of the in situ bioassay were assessed using an international ring test. This study used five plots located at a former industrial site and six laboratories participated in the ring test. The results revealed the impact of environmental parameters on the bioavailability of metal(loid)s and PAHs to snails exposed in the field to structured soils and vegetation compared to those exposed under laboratory conditions to soil collected from the same field site (excavated soils). The risk coefficients were generally higher ex situ than in situ, with some exceptions (mainly due to Cd and Mo), which might be explained by the in situ contribution of plants and humus layer as sources of exposure of snails to contaminants and by climatic parameters. The ring test showed good agreement among laboratories, which determined the same levels of risk in most of the plots. Comparison of the bioavailability to land snails and the subsequent risk estimated in situ or ex situ highlighted the complementarity between both approaches in the environmental risk assessment of contaminated soils, namely, to guide decisions on the fate and future use of the sites (e.g., excavation, embankments, and land restoration).

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Bioaccessibility of metal(loid)s in soils to humans and their bioavailability to snails: A way to associate human health and ecotoxicological risk assessment?

Cited by 21 publications

References 43 publications

Bioavailability Evaluation of Perchlorate in Different Foods In Vivo: Comparison with In Vitro Assays and Implications for Human Health Risk Assessment

Bioavailability Evaluation of Perchlorate in Different Foods In Vivo: Comparison with In Vitro Assays and Implications for Human Health Risk Assessment

Dose-dependent effects of lead and cadmium and the influence of soil properties on their uptake by Helix aspersa: an ecotoxicity test approach

In situ and ex situ bioassays with Cantareus aspersus for environmental risk assessment of metal(loid) and PAH‐contaminated soils

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