Bioaccumulation and metabolic response of PFAS mixtures in wild-caught freshwater turtles (Emydura macquarii macquarii) using omics-based ecosurveillance techniques

Beale, David J.; Hillyer, Katie E.; Nilsson, Sandra; Limpus, Duncan J.; Bose, Utpal; Broadbent, James A.; Vardy, Suzanne

doi:10.1016/j.scitotenv.2021.151264

Cited by 26 publications

(17 citation statements)

References 59 publications

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“…Only few studies reported these compounds in biota. FBSA has previously been detected in fish tissues [4,1], FBSA and FHxSA in the blood serum of turtles [2] and to our knowledge, this is the first study to report FBSA and FHxSA in cetacean tissues. FOSA was the most abundant perfluorosulfonamide followed by FHxSA and FBSA in all the tissues.…”

Section: Resultssupporting

confidence: 50%

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First investigation of per-and poly fluoroalkylsubstances (PFAS) in striped dolphin Stenella coeruleoalba stranded along Tuscany coast (north western Mediterranean Sea)

Mazzetti

Marsili

Valsecchi

et al. 2022

Ninth International Symposium “Monitoring of Mediterranean Coastal Areas: Problems and Measurement Techniques”

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Per- and poly fluoroalkylsubstances (PFAS) were measured in liver,muscle, blood and brain of 26 stripped dolphin Stenella coeruleoalba stranded along Tuscany coasts (Italy), from 2020 to 2022. Using high performance liquid chromatography coupled with high resolution mass spectrometry 18 target were quantified in each sample. PFOS, PFHxS, FOSA were found in all samples with PFOS blood concentration level ranging from some tens to some hundreds of µg/kg. The concentrations follow the trend PFOS>FOSA>PFHxS and the PFOS concentration appears to be inversely proportional to the weight of the animals.

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Section: Resultssupporting

confidence: 50%

“…This trend is consistent with most of the published data for wildlife species. The long-chain PFAS may cross cerebral barriers more effectively than short-chain PFAS and in addition they have stronger association with phospholipids that can enhance the bioaccumulation in phospholipids rich tissue such as the brain [2].…”

Section: Resultsmentioning

confidence: 99%

First investigation of per-and poly fluoroalkylsubstances (PFAS) in striped dolphin Stenella coeruleoalba stranded along Tuscany coast (north western Mediterranean Sea)

Mazzetti

Marsili

Valsecchi

et al. 2022

Ninth International Symposium “Monitoring of Mediterranean Coastal Areas: Problems and Measurement Techniques”

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“…Such assessments, therefore, do not indicate the bioavailability, stability, turnover, or distribution of the substances within the system. This can be a particular problem for contaminants such as perfluoroalkyl substances (PFAS), which are numerous (many undocumented), highly mobile, and are known to bioaccumulate in multiple trophic levels [ 3 , 4 ]; for long-lived contaminants that can bind to and release from sediments (e.g. metals); or, for contaminants that are formed in the system itself (e.g.…”

Section: Environmental Monitoringmentioning

confidence: 99%

“…Bivalves exposed to metals such as cadmium, copper, lead, and zinc have shown an increased abundance of proteins associated with stress responses, cytoskeletal activity, and protein synthesis [ 74 ]. A recent multi-omics study from our group, investigating freshwater turtles exposed to PFAS, identified signs of elevated immune activity and perturbed lipid transport and binding [ 3 ]. In addition to monitoring the aquatic environment, transcriptomic- and proteomic-based experiments have provided evidence that herbicides can affect life cycle mechanisms including moulting and the reproduction process of the springtail Folsomia candida [ 75 ].…”

Section: Environmental Monitoringmentioning

confidence: 99%

Omics-based ecosurveillance for the assessment of ecosystem function, health, and resilience

Beale

Jones

Bose

et al. 2022

Emerging Topics in Life Sciences

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Current environmental monitoring efforts often focus on known, regulated contaminants ignoring the potential effects of unmeasured compounds and/or environmental factors. These specific, targeted approaches lack broader environmental information and understanding, hindering effective environmental management and policy. Switching to comprehensive, untargeted monitoring of contaminants, organism health, and environmental factors, such as nutrients, temperature, and pH, would provide more effective monitoring with a likely concomitant increase in environmental health. However, even this method would not capture subtle biochemical changes in organisms induced by chronic toxicant exposure. Ecosurveillance is the systematic collection, analysis, and interpretation of ecosystem health-related data that can address this knowledge gap and provide much-needed additional lines of evidence to environmental monitoring programs. Its use would therefore be of great benefit to environmental management and assessment. Unfortunately, the science of ‘ecosurveillance’, especially omics-based ecosurveillance is not well known. Here, we give an overview of this emerging area and show how it has been beneficially applied in a range of systems. We anticipate this review to be a starting point for further efforts to improve environmental monitoring via the integration of comprehensive chemical assessments and molecular biology-based approaches. Bringing multiple levels of omics technology-based assessment together into a systems-wide ecosurveillance approach will bring a greater understanding of the environment, particularly the microbial communities upon which we ultimately rely to remediate perturbed ecosystems.

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“…Between 2000 and 2002, production of the parent chemical to PFOS and its precursors was phased out in North America. , Much of the chemistry then shifted to perfluorobutane sulfonyl fluoride derivatives, with reported uses in semiconductor manufacturing . This has resulted in detection of perfluorobutane sulfonamide (FBSA), the C4 precursor, in products and environmental samples. ,, Perfluorohexane sulfonamide (FHxSA), the C6 precursor, is frequently detected at airports and military fire-training areas due to historical use of AFFF manufactured by 3M using electrochemical fluorination (ECF AFFF). − Recent studies have detected FBSA and FHxSA in fish ,,, and other species, ,− suggesting short-chain FASA (≤C6) may bioaccumulate.…”

Section: Introductionmentioning

confidence: 99%

Bioaccumulation of Perfluoroalkyl Sulfonamides (FASA)

Pickard,

Haque,

Sunderland

2024

Environ. Sci. Technol. Lett.

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Hundreds of sites across the United States have high concentrations of perfluoroalkyl sulfonamides (FASA), but little is known about their propensity to accumulate in fish. FASA are precursors to terminal per- and polyfluoroalkyl substances (PFAS) that are abundant in diverse consumer products and aqueous film-forming foams manufactured using electrochemical fluorination (ECF AFFF). In this study, FASA with C3–C8 carbon chain lengths were detected in all fish samples from surface waters up to 8 km downstream of source zones with ECF AFFF contamination. Short-chain FASA ≤ C6 have rarely been included in routine screening for PFAS, but availability of new standards makes such analyses more feasible. Bioaccumulation factors (BAF) for FASA were between 1 and 3 orders of magnitude greater than their terminal perfluoroalkyl sulfonates. Across fish species, BAF for FASA were greater than for perfluorooctanesulfonate (PFOS), which is presently the focus of national advisory programs. Similar concentrations of the C6 FASA (<0.36–175 ng g–1) and PFOS (0.65–222 ng g–1) were detected in all fish species. No safety thresholds have been established for FASA. However, high concentrations in fish next to contaminated sites and preliminary findings on toxicity suggest an urgent need for consideration by fish advisory programs.

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Bioaccumulation and metabolic response of PFAS mixtures in wild-caught freshwater turtles (Emydura macquarii macquarii) using omics-based ecosurveillance techniques

Cited by 26 publications

References 59 publications

First investigation of per-and poly fluoroalkylsubstances (PFAS) in striped dolphin Stenella coeruleoalba stranded along Tuscany coast (north western Mediterranean Sea)

First investigation of per-and poly fluoroalkylsubstances (PFAS) in striped dolphin Stenella coeruleoalba stranded along Tuscany coast (north western Mediterranean Sea)

Omics-based ecosurveillance for the assessment of ecosystem function, health, and resilience

Bioaccumulation of Perfluoroalkyl Sulfonamides (FASA)

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