Bioaccumulation of 14C-17α-ethinylestradiol by the aquatic oligochaete Lumbriculus variegatus in spiked artificial sediment

Liebig, Markus; Egeler, Philipp; Oehlmann, Jörg; Knacker, Thomas

doi:10.1016/j.chemosphere.2004.10.051

Cited by 40 publications

(20 citation statements)

References 23 publications

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“…Ability to concentrate steroids from the surrounding water has been demonstrated in cnidarians (Tarrant et al 2001), oligochaetes (Liebig et al 2005), and oysters (Le Curieux-Belfond et al 2005), and this could explain in several instances the presence of vertebrate-type steroids in these animals. It is likely that the same situation exists in many cases, and that also dietary steroids may accumulate, yet with (or without) biological effects.…”

Section: Biosynthesismentioning

confidence: 94%

Steroids in aquatic invertebrates

2007

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Steroid molecules are present in all invertebrates, and some of them have established hormonal roles: this is the case for ecdysteroids in arthropods and, to a lesser extent, for vertebrate-type steroids in molluscs. Steroids are not only hormones, they may also fulfill many other functions in chemical communication, chemical defense or even digestive physiology. The increasing occurrence of endocrine disruption problems caused by environmental pollutants, which interfere in particular with reproductive physiology of vertebrates but also of invertebrates has made necessary to better understand the endocrine physiology of the latter and the role of steroids in these processes. So many attempts are being made to better understand the endocrine roles of steroids in arthropods and molluscs, and to establish whether they also fulfill similar functions in other invertebrate phyla. At the moment, both the precise identification of these steroids, the determination of their origin (endogenous versus exogenous) and of their mechanism of action are under active investigation. This research takes profit of the development of genome sequencing programs on many invertebrate species, which allow the identification of receptors and/or biosynthetic enzymes, when related to their vertebrate counterparts, but the story is not so simple, as will be exemplified by estrogen receptors of molluscs.

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Section: Biosynthesismentioning

confidence: 94%

Steroids in aquatic invertebrates

2007

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“…Furthermore, several laboratory experiments and field studies have illustrated that low doses of EDCs can cause undesirable effects if the exposure is continuous (Pickford et al 2003;Sumpter and Johnson 2005). The bioaccumulation of these estrogenic chemicals is also drawing increasing attention with varying degrees found in several kinds of aquatic species (Larsson et al 1999;Länge et al 2001;Liebig et al 2004;Tyler et al 2005). Hence, it is reasonably expected that the local aquatic organisms in the river have been considerably affected by EDCs, which warrants the need for such evaluations in future studies.…”

Section: Risk Assessmentmentioning

confidence: 96%

Occurrence and environmental risk of endocrine-disrupting chemicals in surface waters of the Pearl River, South China

Gong

Ran

Chen

et al. 2008

Environ Monit Assess

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The occurrence and environmental risk of endocrine-disrupting chemicals was investigated in the surface water samples of the Zhujiang and Dongjiang rivers, Pearl River Delta (PRD) of South China. Thirty surface water samples were collected in the dry season and analyzed by using an MSTFA derivation and a GC-MS-SIM method. Concentrations of biphenol A (BPA) ranged from 43.5 to 639.1 ng L( - 1), and concentrations of estrone (E1) and 17beta-estradiol (E2) ranged from <1.5 to 8.2 ng L( - 1) and from <1.1 to 1.7 ng L( - 1), respectively. The spatial distribution of these chemicals was related to the discharge of domestic and industrial wastewater along the rivers. The highly significant correlation among BPA, E1, and dissolved organic carbon (DOC) might be related to their same contamination source and/or their association with colloidal organic carbon of DOC in the river samples. Compared with other studied rivers in the world, the estrogenic contamination in the investigated rivers was high for BPA and moderate for E1. As the average estrogenic activity in E2 activity equivalent (E2eq; 1.16 ng E2eq L( - 1)) for the target BAP, E1, and E2 combined with those for nonyphenol and octylphenol, which were previously reported, exceeds documented effect levels in the investigated river waters for some aquatic species, they may pose a high risk to the local aquatic organisms.

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“…Mass spectrometric methods and techniques combining two chromatographic separation steps such as GC-MS(MS) and LC-MS(MS) (Marcomini et al 1987;Jeannot et al 2000;Li et al 2000;Reemtsma et al 2002;Braun et al 2003;Clara et al 2004a;Kloepfer et al 2004b;Stehmann and Schrö eder 2004;Einchorn et al 2005;Huber et al 2005;Weber et al 2005;Moeder et al 2006;Ternes 1998;Rychlowska et al 2003;Luthje et al 2004) and the use of radiolabelled tracers (Ingerslev et al 2001;Doi et al 2002;Lalah et al 2003;Corvini et al 2004;Liebig et al 2005) are only few examples of analytical techniques to identify and analyse organic micropollutants and their degradation products occurring in wastewater. In parallel, the importance of detecting micropollutants was emphasized through the development of biotests (e.g., specialized to identify compounds with endocrine disrupting properties), which pointed out to the high biological activity of some class of micropollutants.…”

Section: Introductionmentioning

confidence: 98%

Factors affecting the removal of organic micropollutants from wastewater in conventional treatment plants (CTP) and membrane bioreactors (MBR)

Cirja

Ivashechkin

Schäffer

et al. 2007

Rev Environ Sci Biotechnol

277

153

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As a consequence of insufficient removal during treatment of wastewater released from industry and households, different classes of organic micropollutants are nowadays detected in surface and drinking water. Among these micropollutants, bioactive substances, e.g., endocrine disrupting compounds and pharmaceuticals, have been incriminated in negative effects on living organisms in aquatic biotope. Much research was done in the last years on the fate and removal of those compounds from wastewater. An important point it is to understand the role of applied treatment conditions (sludge retention time (SRT), biomass concentration, temperature, pH value, dominant class of micropollutants, etc.) for the efficiency of conventional treatment plants (CTP) and membrane bioreactors (MBR) concerning the removal of micropollutants such as pharmaceuticals, steroid- and xeno-estrogens. Nevertheless, the removal rates differ even from one compound to the other and are related to the ph ysico-chemical characteristics of the xenobiotics

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Bioaccumulation of 14C-17α-ethinylestradiol by the aquatic oligochaete Lumbriculus variegatus in spiked artificial sediment

Cited by 40 publications

References 23 publications

Steroids in aquatic invertebrates

Steroids in aquatic invertebrates

Occurrence and environmental risk of endocrine-disrupting chemicals in surface waters of the Pearl River, South China

Factors affecting the removal of organic micropollutants from wastewater in conventional treatment plants (CTP) and membrane bioreactors (MBR)

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