Bioaccumulation of the lipophilic metabolites of nonionic surfactants in freshwater organisms

Ahel, Marijan; McEvoy, J.; Giger, Walter

doi:10.1016/0269-7491(93)90096-7

Cited by 332 publications

(165 citation statements)

References 15 publications

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“…NP is also accumulated to a considerable degree in various plants and animals living in aquatic environments, and their bioconcentration factors in food chains of the ecologic system have shown very divergent values (13-to 1,000-fold; Ahel et al 1993). Judging from our present results, if we intake these bioorganisms as foods, these concentrations of NP seem to cause possible toxic effects on the body through ROS generation of immunocompetent cells, including blood neutrophils.…”

mentioning

confidence: 41%

“…They are degraded to free para-nonylphenol (NP) in seawater or sewage sludge (Ekeland et al 1993;Giger et al 1984), and it accumulates in plants and animals in the aquatic environment (Ahel et al 1993). Furthermore, NP leaks from autoclaved plastic and increases the cell growth and progesterone receptor expression of mammary tumor cells (Soto et al 1991), and stimulates the production of the estrogenic protein vitellogenin in fish hepatocytes (Jobling and Sumpters 1993).…”

mentioning

confidence: 99%

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Enhancing effect of the endocrine disruptor para-nonylphenol on the generation of reactive oxygen species in human blood neutrophils.

Okai¹,

Sato²,

Higashi‐Okai³

et al. 2004

Environ Health Perspect

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Although para-nonylphenol (NP) is known as an endocrine disruptor, the immunologic effect of NP has been poorly analyzed. We found that NP from 5 to 50 microM caused a dose-dependent stimulatory effect on the generation of reactive oxygen species (ROS) in human blood neutrophils, which was measured by using a chemiluminescence reagent, luminol. Furthermore, ROS-scavenging enzymes such as catalase and superoxide dismutase and antioxidative agents alpha-tocopherol and beta-carotene showed strong preventive effects on NP-induced ROS generation. To analyze the biochemical mechanism of NP-induced ROS generation in human neutrophils, we investigated the effects of different types of metabolic inhibitor for the activation pathways of ROS generation in the cells. Reduced nicotinamide adenine dinucleotide phosphate (NADPH)-dependent oxidase inhibitor, diphenyl iodonium chloride and the myeloperoxidase inhibitor sodium azide (NaN3) showed remarkable inhibitory effects on ROS generation induced by NP, but an inhibitor against mitochondrial respiratory function, potassium cyanide (KCN), did not exhibit significant effect. Furthermore, the phosphatidylinositol-3 (PI3) kinase inhibitor wortmannin and the tyrosine kinase inhibitor protein phosphorylation inhibitor 1 (PP1) caused strong suppression against NP-induced ROS generation. The selective protein kinase C inhibitor Ro-32-0432, p38 MAP kinase inhibitor SB 203580, and ERK MAP kinase inhibitor PD 98059 also showed significant suppressive effects on NP-induced ROS generation. These results suggest that NP causes an enhancing effect on ROS generation in human blood neutrophils through the activation of signal transduction pathways associated with the respiratory burst function in these cells. Additionally, to examine in vivo effects of NP, we also analyzed the effects of NP itself and the synergistic effects of NP and a typical inflammatory agent, opsonized zymosan, on human whole blood including neutrophils.

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mentioning

confidence: 41%

mentioning

confidence: 99%

Enhancing effect of the endocrine disruptor para-nonylphenol on the generation of reactive oxygen species in human blood neutrophils.

Okai¹,

Sato²,

Higashi‐Okai³

et al. 2004

Environ Health Perspect

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“…NP possesses oestrogenic properties and has been shown to disrupt the male reproductive system of fish, reptiles and mammals [9][10][11]. The residual nature of nonylphenol and its lipophilic character leads to its accumulation in the lipids of living organisms [7,12,13]. Neonatal exposure of rats to NP had an effect on the weight of the reproductive organs and delayed testes descent, whereas exposure of adult rats affects spermatogenesis [14,15].…”

Section: Introductionmentioning

confidence: 99%

Combined action of X-rays and nonylphenol on mouse sperm

Dobrzyńska

2011

Open Life Sciences

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The aim of this study was to assess the effects of 2-weeks’ X-ray and/or nonylphenol (NP) exposure on male mice’s sperm count and quality. Pzh:SFIS mice were exposed to X-rays (0.05 Gy, 0.10 Gy, 0.20 Gy) or to nonylphenol (25 mg/kg bw, 50 mg/kg bw, 100 mg/kg bw) or to both agents (0.05 Gy + 25 mg/kg bw NP, 0.10 Gy + 50 mg/kg bw NP). At 24 h and 5 weeks after the end of exposure the sperm count, morphology and frequency of DNA damage in the male germ cells were estimated. Each agent alone diminished sperm count and morphology. The dose of 0.05 Gy of X-rays decreased the frequency of DNA damage. Combined exposure to lower doses of both agents significantly improved sperm morphology and decreased the level of DNA damage compared to one agent alone. Combined exposure to higher doses reduced the frequency of DNA damage compared to the effect of the appropriate dose of NP. Results of combined exposure to low doses of both agents suggest that 0.05 Gy of X-rays stimulate the DNA damagecontrol system and in consequence repair of DNA caused by X-rays and NP. It may be correlated with increased antioxidant capacity.

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“…Nonylphenol is one of the organic pollutants found in aquatic environments as a consequence of the biodegradation of nonylphenol polyethoxylate (NPnEO), a non-ionic surfactant contained in industrial cleaning products and in household detergents (Ahel et al, 1993).…”

Section: Introductionmentioning

confidence: 99%

Cyclodextrin-linked alginate beads as supporting materials for Sphingomonas cloacae, a nonylphenol degrading bacteria

Pluemsab

Fukazawa

Furuike

et al. 2007

Bioresource Technology

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Calcium alginate beads covalently linked with -cyclodextrin (-CD-alginate beads) were prepared and examined for their ability to serve as a supporting matrix for bacterial degradation of nonylphenol, an endocrine disruptor. Column chromatographic experiment using -CD-alginate beads with diameter of 657 ± 82 m and with degree of CD substitution of 0.16 showed a strong affinity for nonylphenol adsorption. Although addition of -CD (2.7-27 mM) to the culture broth of Sphingomonas cloacae retarded nonylphenol degradation, the immobilized bacteria on the CD-alginate beads were effective for the degradation. Batch degradation tests using the immobilized bacteria on -CD-alginate-beads showed 46% nonylphenol recovery after 10-day incubation at 25 ± 2 °C, and the recovery reached to about 17% when wide and shallow incubation tubes were used to facilitate uptake of the viscous liquid of nonylphenol on the surface of the medium. Scanning electron microscopic photographs revealed that multiplicated bacteria was present both on the surface and inside the beads and the matrix of CD-alginate was stable and suitable during 10-day incubation.

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Bioaccumulation of the lipophilic metabolites of nonionic surfactants in freshwater organisms

Cited by 332 publications

References 15 publications

Enhancing effect of the endocrine disruptor para-nonylphenol on the generation of reactive oxygen species in human blood neutrophils.

Enhancing effect of the endocrine disruptor para-nonylphenol on the generation of reactive oxygen species in human blood neutrophils.

Combined action of X-rays and nonylphenol on mouse sperm

Cyclodextrin-linked alginate beads as supporting materials for Sphingomonas cloacae, a nonylphenol degrading bacteria

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