Bioaccumulation potential of bisphenols and benzophenone UV filters: A multiresidue approach in raptor tissues

González-Rubio, Soledad; Vike-Jonas, Kristine; González, Susana Villa; Ballesteros‐Gómez, Ana; Sonne, Christian; Dietz, Runé; Boertmann, David; Rasmussen, Lars Maltha; Jaspers, Veerle L.B.; Asimakopoulos, Alexandros G.

doi:10.1016/j.scitotenv.2020.140330

Cited by 28 publications

(17 citation statements)

References 43 publications

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“…The target analytes studied here and their main physicochemical properties are listed in Table S1. Other relevant information was reported by González-Rubio et al (2020) [30]. Standards of BPA (≥99%), BPAF (≥99%), bisphenol B (BPB, ≥98%), BPF (≥98%), BPS (≥98%), bisphenol M (BPM, ≥99%), bisphenol P (BPP, ≥99%), benzophenone-1 (BzP-1, ≥99%), benzophenone-2 (BzP-2, ≥97%), benzophenone-8 (BzP-8, ≥98%) and 4hydroxybenzophenone (4-OH-BzP, ≥98%) were purchased from Sigma-Aldrich (Steinheim, Germany).…”

Section: Experimental Section 21 Chemicals and Materialsmentioning

confidence: 88%

“…Liver samples of 0.1-0.2 g were placed into 15 mL polypropylene (PP) tubes and the target analytes were extracted from the liver matrix and analyzed using the protocol reported by González-Rubio et al (2020) [30]. Briefly, the sample preparation method involved the incubation of the samples in ammonium acetate (1.0 M) with β-glucuronidase at 37 • C for 12 h to establish total concentrations (free and conjugated chemical species), followed by solid-liquid extraction with ethyl acetate.…”

Section: Sample Preparation and Analysismentioning

confidence: 99%

“…Similarly, the MDLs and MQLs were estimated for every target analyte as 3 and 10 times the signal-to-noise ratio, respectively, by using a fortified liver sample with an amount of 2.5 ng (corrected for endogenous amounts). Estimation of MEs (%) during analysis was performed as described by González-Rubio et al (2020) [30]. UPLC-MS/MS data were acquired with the MassLynx v4.1 software, while quantification processing was performed with TargetLynx (Waters, Milford, MA, USA).…”

Section: Quality Assurance and Quality Control (Qa/qc)mentioning

confidence: 99%

“…In particular, BPAF has been produced annually at a rate of 4.5-230 tons in the USA in 2008 [20], while nowadays it is produced at a rate of 100-1000 tons per year in Europe [45]. The production rise in Europe can explain the higher detection rate for BPAF in white-tailed eagles from Norway compared to the study of González-Rubio et al (2020) [30], where the raptor samples were collected from Greenland before 2008 when the production in the USA was significantly lower. Although there are no data on the effects of BPAF in raptors, malformation and lower survival rate at an exposure concentration of 5 µg/L was reported in zebrafish offspring [46].…”

Section: Occurrence Of Bpsmentioning

confidence: 99%

“…Nonetheless, relevant biomonitoring data regarding the occurrence and distribution of BPs and BzPs in raptors remains scarce. So far, only one peer-reviewed study has been published on BPs and BzPs in raptor tissues from France and Greenland [30], and there is a lack of data on other places in Europe, especially in Scandinavia. With this background, the present study aims to explore for the first time the occurrence of BPs and BzPs in raptors from Northern Europe.…”

Section: Introductionmentioning

confidence: 99%

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Occurrence of Bisphenols and Benzophenone UV Filters in White-Tailed Eagles (Haliaeetus albicilla) from Smøla, Norway

Oró-Nolla

Lacorte

Vike-Jonas

et al. 2021

Toxics

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There is a growing concern about the occurrence of bisphenols and benzophenone UV filters in natural ecosystems, while data are limited regarding their actual occurrence in wildlife species, especially in raptors. In this study, concentrations of bisphenol and benzophenone UV filter analogues were determined in liver tissue samples (n = 38) from white-tailed eagles (Haliaeetus albicilla) that were found dead in Smøla (2006–2018), which is a Norwegian municipality that holds one of the densest breeding populations of white-tailed eagles in Europe. Bisphenol AF (BPAF; a fluorinated analogue) was the most ubiquitous contaminant since it was detected in 32 liver samples at concentrations ranging from 1.08 to 6.68 ng/g wet weight (w.w.), followed by bisphenol A (BPA, mean 10.4 ng/g w.w.), benzophenone-1 (BzP-1, mean 3.24 ng/g w.w.), and 4-hydroxybenzophenone (4-OH-BzP, mean 0.62 ng/g w.w.). The concentrations found in livers suggested that white-tailed eagles potentially accumulate bisphenols and benzophenone UV filters, which raises concern, as these plastic and personal care product-related emerging contaminants can show endocrine-disrupting properties. The high detection frequency of the fluorinated BPAF warrants further attention as other fluorinated compounds have proven to be extremely persistent and potentially harmful to wildlife.

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Section: Experimental Section 21 Chemicals and Materialsmentioning

confidence: 88%

Section: Sample Preparation and Analysismentioning

confidence: 99%

Section: Quality Assurance and Quality Control (Qa/qc)mentioning

confidence: 99%

Section: Occurrence Of Bpsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Occurrence of Bisphenols and Benzophenone UV Filters in White-Tailed Eagles (Haliaeetus albicilla) from Smøla, Norway

Oró-Nolla

Lacorte

Vike-Jonas

et al. 2021

Toxics

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Toxicity Screening of Bisphenol A Replacement Compounds: Cytotoxicity and mRNA Expression in Primary Hepatocytes of Chicken and Double‐Crested Cormorant

Sharin

Williams

Chiu

et al. 2021

Enviro Toxic and Chemistry

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A market for bisphenol A (BPA) replacement compounds has emerged as a result of restrictions on the use of BPA. Some of these compounds have been detected in the environment; however, little is known about their toxicological properties. In the present study, an avian in vitro toxicogenomic approach was used to compare the effects of 5 BPA alternatives. Cell viability and mRNA expression were compared in primary embryonic hepatocytes of chicken (CEH) and double‐crested cormorant (DCEH) exposed to 4,4′‐(propane‐2,2‐diyl) diphenol (BPA), bis (4‐hydroxyphenyl) methane (BPF), bis (3‐allyl‐4‐hydroxyphenyl) sulfone (TGSH), 7‐bis (4‐hydroxyphenylthio)‐3,5‐dioxaheptane (DD‐70), 2,2‐bis (4‐hydroxyphenyl) hexafluoropropane (BPAF), and 4‐hydroxyphenyl 4‐isoprooxyphenylsulfone (BPSIP). Changes in gene expression were determined using 2 polymerase chain reaction (PCR) arrays: 1) species‐specific ToxChips that contain genes representing toxicologically relevant pathways, and 2) chicken‐specific AestroChip that measures estrogen responsive genes. In CEH and DCEH, BPA alternatives TGSH, DD‐70, and BPAF were most cytotoxic. Some of the replacement compounds changed the expression of genes related to xenobiotic metabolism, bile acid, and cholesterol regulation. The rank order based on the number of genes altered on the chicken ToxChip array was TGSH > DD‐70 > BPAF = BPF > 17β estradiol (E2) > BPSIP > BPA. On the cormorant ToxChip array, BPSIP altered the greatest number of genes. Based on the chicken AestroChip data, BPSIP and BPF were slightly estrogenic. These results suggest that the replacement compounds have comparable or even greater toxicity than BPA and act via different mechanisms. Environ Toxicol Chem 2021;40:1368–1378. © 2021 Her Majesty the Queen in Right of Canada. Reproduced with the permission of the Minister of Environment and Climate Change Canada.

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Toxicity screening of bisphenol A replacement compounds: cytotoxicity and mRNA expression in LMH 3D spheroids

Sharin

Crump

O’Brien

2022

Environ Sci Pollut Res

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Previously, we showed that the chicken LMH cell line cultured as 3D spheroids may be a suitable animal free alternative to primary chicken embryonic hepatocytes (CEH) for avian in vitro chemical screening. In this study, cytotoxicity and mRNA expression were determined in LMH 3D spheroids following exposure to bisphenol A (BPA), five BPA replacement compounds (BPF, TGSH, DD-70, BPAF, BPSIP), and 17β estradiol (E2). Results were compared to an earlier study that evaluated the same endpoints for these chemicals in CEH. BPA and the replacement compounds had LC50 values ranging from 16.6 to 81.8 μM; DD-70 and BPAF were the most cytotoxic replacements (LC50 = 17.23 ± 4.51 and 16.6 ± 4.78 μM). TGSH and DD-70 modulated the greatest number of genes, although fewer than observed in CEH. Based on the expression of apovitellenin and vitellogenin, BPAF was the most estrogenic compound followed by BPF, BPSIP, and BPA. More estrogen-responsive genes were modulated in LMH spheroids compared to CEH. Concentration-dependent gene expression revealed that DD-70 and BPAF altered genes related to lipid and bile acid regulation. Overall, cytotoxicity and clustering of replacements based on gene expression profiles were similar between LMH spheroids and CEH. In addition to generating novel gene expression data for five BPA replacement compounds in an in vitro avian model, this research demonstrates that LMH spheroids may represent a useful animal free alternative for avian toxicity testing.

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Bioaccumulation potential of bisphenols and benzophenone UV filters: A multiresidue approach in raptor tissues

Cited by 28 publications

References 43 publications

Occurrence of Bisphenols and Benzophenone UV Filters in White-Tailed Eagles (Haliaeetus albicilla) from Smøla, Norway

Occurrence of Bisphenols and Benzophenone UV Filters in White-Tailed Eagles (Haliaeetus albicilla) from Smøla, Norway

Toxicity Screening of Bisphenol A Replacement Compounds: Cytotoxicity and mRNA Expression in Primary Hepatocytes of Chicken and Double‐Crested Cormorant

Toxicity screening of bisphenol A replacement compounds: cytotoxicity and mRNA expression in LMH 3D spheroids

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