Bioactive alkaloids from Brunsvigia radulosa

Alkaloids from Eucharis amazonica (Amaryllidaceae).

“…Compound 3 (apohaemanthamine), C 16 H 15 NO 3 , was recently obtained by semisynthesis from crinamine 7) and all spectroscopic data closely matches those of the natural compound.…”

“…Fraction II by PTLC using n-hexane-AcOEt (70 : 30) saturated with NH 3 atmosphere, yielded 3-epimacronine (24 mg) and haemanthamine (16 mg). Fraction III subjected to PTLC, eluting with n-hexane-AcOEt 7) Lycorine, 9) ismine, 10) trisphaeridine, 10) tazettine, 11) 3-epimacronine, 3) galanthamine, 3) 3-O-methylgalanthamine, 12) haemanthamine, 3) vittatine, 13) and 8-O-demethylmaritidine, 3) were identified by comparing their chromatographic and spectroscopic properties (TLC, [a] D , circular dichroism (CD), IR, MS, 1 H-and 13 C-NMR) with those of authentic samples obtained from other plant sources.…”

Novel Lycorine Derivatives as Anticancer Agents: Synthesis and In Vitro Biological Evaluation

“…Hundreds of alkaloids have been isolated and extensively studied for their pharmacological properties since 1877 [7]. Lycorine is one of the most common alkaloids within Amaryllidaceae family of plants and reportedly exhibits promising anticancer properties [7][8][9][10][11][12].…”

“…Lycorine has displayed multiple inhibitory properties towards various cancer cell lines, including lymphoma [7], carcinoma [8], multiple myeloma [9], melanoma [10], leukemia [7,11], human U373 glioblastoma, human A549 non-small-cell-lung cancer, human OE21 esophageal cancer and human Hs683 anaplastic oligodendroglioma cell lines [12]. Previous studies revealed that lycorine exhibited significantly higher antiproliferative activities in cancer cells than in normal cells, and it could be used to combat cancer cells which may or may not be sensitive to proapoptotic stimuli [12].…”

Ethnobotanical, phytochemical and pharmacological properties of <i>Crinum bulbispermum</i> (Burm f) Milne-Redh and Schweick (Amaryllidaceae)

“…Other researchers like Campbell et al [56] evaluated cytotoxicity activities of alkaloids associated with C. bulbispermum reporting IC 50 values of 0.6 and 0.7 μg/mL for lycorine 1 against the strains D-10 and FAC8, respectively. Likhitwitaywuid et al [52] reported IC 50 values for ranging from 0.3 to 1.6 μg/mL against a series of human cancer cells.…”