Bioactive and Biocompatible Silica/Pseudowollastonite Aerogels

Reséndiz-Hernández, P.J.; Cortés-Hernández, Dora A.; Nonell, Juan Méndez; Escobedo‐Bocardo, José C.

doi:10.4028/www.scientific.net/ast.96.21

Cited by 9 publications

(5 citation statements)

References 14 publications

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“…Another biomaterial with exceptional properties and being more biocompatible within cells is silica aerogel. Their main limitations however, are fragility and high hygroscopicity [ 76 ]. In a study by Lazar et al, silica aerogel was hybridised with industrial manufactured bovine casein, using tetramethyl orthosilicate (TMOS) and co-gelation.…”

Section: Biomedical Applications Of Aerogelmentioning

confidence: 99%

Emerging Trends in Nanotechnology: Aerogel-Based Materials for Biomedical Applications

et al. 2023

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At present, aerogel is one of the most interesting materials globally. The network of aerogel consists of pores with nanometer widths, which leads to a variety of functional properties and broad applications. Aerogel is categorized as inorganic, organic, carbon, and biopolymers, and can be modified by the addition of advanced materials and nanofillers. Herein, this review critically discusses the basic preparation of aerogel from the sol–gel reaction with derivation and modification of a standard method to produce various aerogels for diverse functionalities. In addition, the biocompatibility of various types of aerogels were elaborated. Then, biomedical applications of aerogel were focused on this review as a drug delivery carrier, wound healing agent, antioxidant, anti-toxicity, bone regenerative, cartilage tissue activities and in dental fields. The clinical status of aerogel in the biomedical sector is shown to be similarly far from adequate. Moreover, due to their remarkable properties, aerogels are found to be preferably used as tissue scaffolds and drug delivery systems. The advanced studies in areas including self-healing, additive manufacturing (AM) technology, toxicity, and fluorescent-based aerogel are crucially important and are further addressed.

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Section: Biomedical Applications Of Aerogelmentioning

confidence: 99%

Emerging Trends in Nanotechnology: Aerogel-Based Materials for Biomedical Applications

et al. 2023

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“…Subsequently, a second publication accentuated the value of these tests [ 104 ] in approximating the in vivo bioactivity of distinct categories of bone substitute materials. Several works have effectively extended the application of Kokubo’s test to aerogel-based bone substitute materials [ 62 , 66 , 77 , 105 ]. Expanding on the original formulation, researchers have sought modifications to more accurately mirror the comprehensive chemical composition of human blood plasma.…”

Section: Biomechanical In Vitro and In Vivo Properties Toxicity And B...mentioning

confidence: 99%

Aerogel-Based Materials in Bone and Cartilage Tissue Engineering—A Review with Future Implications

Lázár,

Čelko,

Menelaou

2023

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Aerogels are fascinating solid materials known for their highly porous nanostructure and exceptional physical, chemical, and mechanical properties. They show great promise in various technological and biomedical applications, including tissue engineering, and bone and cartilage substitution. To evaluate the bioactivity of bone substitutes, researchers typically conduct in vitro tests using simulated body fluids and specific cell lines, while in vivo testing involves the study of materials in different animal species. In this context, our primary focus is to investigate the applications of different types of aerogels, considering their specific materials, microstructure, and porosity in the field of bone and cartilage tissue engineering. From clinically approved materials to experimental aerogels, we present a comprehensive list and summary of various aerogel building blocks and their biological activities. Additionally, we explore how the complexity of aerogel scaffolds influences their in vivo performance, ranging from simple single-component or hybrid aerogels to more intricate and organized structures. We also discuss commonly used formulation and drying methods in aerogel chemistry, including molding, freeze casting, supercritical foaming, freeze drying, subcritical, and supercritical drying techniques. These techniques play a crucial role in shaping aerogels for specific applications. Alongside the progress made, we acknowledge the challenges ahead and assess the near and far future of aerogel-based hard tissue engineering materials, as well as their potential connection with emerging healing techniques.

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“…Subsequently, a second publication accentuated the value of these tests [104] in approximating the in vivo bioactivity of distinct categories of bone substitute materials. Several works have effectively extended the application of Kokubo's test to aerogel-based bone substitute materials [62,66,77,105]. Expanding on the original formulation, researchers have sought modifications to more accurately mirror the comprehensive chemical composition of human blood plasma.…”

Section: Simulated Body Fluidsmentioning

confidence: 99%

Aerogel Hybrids and Nanocomposites

2023

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at Dallas, USA (1989-91 and 1994). He received a C.Sc degree in the synthesis of new MRI contrast agents in 1994 (Hungarian Academy of Science, Budapest). He initiated and established the aerogel research at the University of Debrecen in 2006. Currently, he works at the Department of Inorganic and Analytical Chemistry as an Associate Professor of Chemistry. For his contribution to the education and research of inorganic and analytical chemistry, he was awarded the Knight's Cross of the Hungarian Order of Merit in 2020. His actual research focuses on two major fields: biomedical applications of new aerogel-based composite materials and the synthesis and study of catalytically or photocatalytically active aerogels. Melita MenelaouMelita Menelaou received her Diploma in Chemical Engineering ( 2004) and her Ph.D. degree (2009) from the Aristotle University of Thessaloniki (Greece). Dr. Menelaou was a member of respected research groups in Asia (Japan-

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Bioactive and Biocompatible Silica/Pseudowollastonite Aerogels

Cited by 9 publications

References 14 publications

Emerging Trends in Nanotechnology: Aerogel-Based Materials for Biomedical Applications

Emerging Trends in Nanotechnology: Aerogel-Based Materials for Biomedical Applications

Aerogel-Based Materials in Bone and Cartilage Tissue Engineering—A Review with Future Implications

Aerogel Hybrids and Nanocomposites

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