Bioactive and mechanically stable hydroxyapatite patterning for rapid endothelialization of artificial vascular graft

Kang, In-Ku; Park, Cheonil; Seong, Yun‐Jeong; Lee, Hyun; Kim, Hyoun‐Ee; Han, Cheol-Min

doi:10.1016/j.msec.2019.110287

Cited by 12 publications

(9 citation statements)

References 54 publications

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“…However, most studies have used relatively easy-to-process polymer materials [ 30 , 31 ]. Even when HA is used, a complex additional process is required, such as reproducing the pattern by placing HA powder in the patterned frame followed by heat treatment [ 32 , 33 ]. Furthermore, most previous studies have focused on cell shape and proliferation [ 34 , 35 ], while there is a lack of research on surface patterns that can control the movement of bone-forming cells on the HA surface, where bone cells directly bond and form new bone.…”

Section: Introductionmentioning

confidence: 99%

Regulation of cell locomotion by nanosecond-laser-induced hydroxyapatite patterning

Lee

Song

et al. 2021

Bioactive Materials

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Hydroxyapatite, an essential mineral in human bones composed mainly of calcium and phosphorus, is widely used to coat bone graft and implant surfaces for enhanced biocompatibility and bone formation. For a strong implant–bone bond, the bone-forming cells must not only adhere to the implant surface but also move to the surface requiring bone formation. However, strong adhesion tends to inhibit cell migration on the surface of hydroxyapatite. Herein, a cell migration highway pattern that can promote cell migration was prepared using a nanosecond laser on hydroxyapatite coating. The developed surface promoted bone-forming cell movement compared with the unpatterned hydroxyapatite surface, and the cell adhesion and movement speed could be controlled by adjusting the pattern width. Live-cell microscopy, cell tracking, and serum protein analysis revealed the fundamental principle of this phenomenon. These findings are applicable to hydroxyapatite-coated biomaterials and can be implemented easily by laser patterning without complicated processes. The cell migration highway can promote and control cell movement while maintaining the existing advantages of hydroxyapatite coatings. Furthermore, it can be applied to the surface treatment of not only implant materials directly bonded to bone but also various implanted biomaterials implanted that require cell movement control.

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Section: Introductionmentioning

confidence: 99%

Regulation of cell locomotion by nanosecond-laser-induced hydroxyapatite patterning

Lee

Song

et al. 2021

Bioactive Materials

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“…[147] Recently, a linear HA pattern was fabricated by photolithography, and then transferred to PLLA matrix using solvent casting to obtain HA patterned PLLA film ( Figure 2C). [148] Compared to normal HA coating on PLLA, the linear HA pattern cannot only exhibit excellent mechanical stability, but also significantly improve EC behavior as well as suppress platelet activation on surface. Huang and co-workers prepared the HA micro-pattern on extracellular matrix (ECM) surface.…”

Section: Surface Patternsmentioning

confidence: 99%

Surface Engineering of Cardiovascular Devices for Improved Hemocompatibility and Rapid Endothelialization

Zhao

Feng

2020

Adv Healthcare Materials

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Cardiovascular devices have been widely applied in the clinical treatment of cardiovascular diseases. However, poor hemocompatibility and slow endothelialization on their surface still exist. Numerous surface engineering strategies have mainly sought to modify the device surface through physical, chemical, and biological approaches to improve surface hemocompatibility and endothelialization. The alteration of physical characteristics and pattern topographies brings some hopeful outcomes and plays a notable role in this respect. The chemical and biological approaches can provide potential signs of success in the endothelialization of vascular device surfaces. They usually involve therapeutic drugs, specific peptides, adhesive proteins, antibodies, growth factors and nitric oxide (NO) donors. The gene engineering can enhance the proliferation, growth, and migration of vascular cells, thus boosting the endothelialization. In this review, the surface engineering strategies are highlighted and summarized to improve hemocompatibility and rapid endothelialization on the cardiovascular devices. The potential outlook is also briefly discussed to help guide endothelialization strategies and inspire further innovations. It is hoped that this review can assist with the surface engineering of cardiovascular devices and promote future advancements in this emerging research field.

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“…A large number of platelets adhere on the surfaces of BC and BC/CA-4, partially showing irregular morphology, aggregation, and widely spread shape, which may indicate activation and potential for thrombus formation. 44,45 The number of adherent platelets was quantified via the LDH assay (Fig. 5B).…”

Section: In Vitro Characterizationmentioning

confidence: 99%

“…The hemolysis rate of BC/CA-2 is 0.28%, which is lower than those of the ePTFE vascular graft (0.9%) reported by Chen et al 49 and an electrospun spider silk protein/PCL/ gelatin graft (0.3%) reported by Xiang et al 50 The formation of a complete endothelial layer on the surface of vascular grafts is crucially important to enhance long-term patency. 45,51 Endothelialization was monitored in vitro by seeding HUVECs onto BC, CA, and BC/CA grafts. The SEM images (Fig.…”

Section: In Vitro Characterizationmentioning

confidence: 99%

Controllable synthesis of biomimetic nano/submicro-fibrous tubes for potential small-diameter vascular grafts

et al. 2020

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Bioactive and mechanically stable hydroxyapatite patterning for rapid endothelialization of artificial vascular graft

Cited by 12 publications

References 54 publications

Regulation of cell locomotion by nanosecond-laser-induced hydroxyapatite patterning

Regulation of cell locomotion by nanosecond-laser-induced hydroxyapatite patterning

Surface Engineering of Cardiovascular Devices for Improved Hemocompatibility and Rapid Endothelialization

Controllable synthesis of biomimetic nano/submicro-fibrous tubes for potential small-diameter vascular grafts

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