Bioactive-Based Poly(anhydride-esters) and Blends for Controlled Drug Delivery

Fogaça, Renata; Ouimet, Michelle A.; Catalani, Luiz H.; Uhrich, Kathryn E.

doi:10.1021/bk-2013-1135.ch003

Cited by 1 publication

(1 citation statement)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Researchers have considered numerous carriers over the past few decades, , and micro- and nanofibers have become an attractive prospective carrier option. − This could be attributed to both the nature of the material used to fabricate the fiber and the nature of this very fabrication process. Additionally, the low initial burst rate compared to spherical vesicles and the controlled zero-order drug release profile, seen in drug loaded fibers, make them more suitable for drug delivery applications. − Materials such as alginate and gelatin used to fabricate these fibers are biocompatible, , thus causing no harm to the tissue of the host.…”

Section: Introductionmentioning

confidence: 99%

Fiber Based Approaches as Medicine Delivery Systems

Sharifi

Sooriyarachchi

Altural

et al. 2016

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

The goal of drug delivery is to ensure that therapeutic molecules reach the intended target organ or tissue, such that the effectiveness of the drug is maximized. The efficiency of a drug delivery system greatly depends on the choice of drug carrier. Recently, there has been growing interest in using micro-and nanofibers for this purpose. The reasons for this growing interest include these materials' high surface area to volume ratios, ease of fabrication, high mechanical properties, and desirable drug release profile. Here, we review developments in using these materials made by the most prevalent methods of fiber fabrication: electrospinning, microfluidics, wet spinning, rotary spinning, and self-assembly for drug delivery purposes. Additionally, we discuss the potential to use these fiber based systems in research and clinical applications.

show abstract