Bioactive Betulin produced by marine Paecilomyces WE3-F

Barakat, Khouloud M.; Saleh, M. M. S.

doi:10.7324/japs.2016.60306

Cited by 12 publications

(10 citation statements)

References 25 publications

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“…There are descriptions on the importance of antibacterial metabolites such as viriditoxin or betulin against non-phytopathogenic bacteria such as S. aureus, Enterococcus sp. Micrococcus sp., Aeromonas Hydrophila, Flavobacterium sp, Pseudomonas aeruginosa , and Vibrio cholera [ 116 , 117 ]. Sornakili et al [ 83 ] recently reported the inhibition of Erwinia carotovora, Xanthomonas oryzae pv oryzae , and Ralstonia solanacearum with in vitro inhibition between 13–45% using P. tenuis , an endophyte isolated from rice leaves.…”

Section: Biological Control Of Diseases Caused By Phytopathogenic mentioning

confidence: 99%

Paecilomyces and Its Importance in the Biological Control of Agricultural Pests and Diseases

Moreno-Gavíra

Huertas

Diánez

et al. 2020

Plants

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Incorporating beneficial microorganisms in crop production is the most promising strategy for maintaining agricultural productivity and reducing the use of inorganic fertilizers, herbicides, and pesticides. Numerous microorganisms have been described in the literature as biological control agents for pests and diseases, although some have not yet been commercialised due to their lack of viability or efficacy in different crops. Paecilomyces is a cosmopolitan fungus that is mainly known for its nematophagous capacity, but it has also been reported as an insect parasite and biological control agent of several fungi and phytopathogenic bacteria through different mechanisms of action. In addition, species of this genus have recently been described as biostimulants of plant growth and crop yield. This review includes all the information on the genus Paecilomyces as a biological control agent for pests and diseases. Its growth rate and high spore production rate in numerous substrates ensures the production of viable, affordable, and efficient commercial formulations for agricultural use.

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Section: Biological Control Of Diseases Caused By Phytopathogenic mentioning

confidence: 99%

Paecilomyces and Its Importance in the Biological Control of Agricultural Pests and Diseases

Moreno-Gavíra

Huertas

Diánez

et al. 2020

Plants

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“…Other absorptions bands observed at 2925.43-2872.11 cm -1 are typical of C-H bond stretching bands. A weak band at 1638.41 cm -1 indicates the presence of a C=C absorption band (Elvira et al, 2009;Correa et al, 2014;Barakat & Saleh., 2016).…”

Section: Enacimentioning

confidence: 99%

Isolation, characterization and biological properties of betulin from Entada africana Guill. and Perr. (Mimosaceae).

Kwaji¹,

Adamu²,

Chindo³

et al. 2018

jaar

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The present study is aimed at the isolation, characterization and evaluation of some biological properties of betulin from Entada africana stem bark extract. A dichloromethane soluble portion of the stem bark methanol/acetone (1:1 v/v) extract was subjected to gradient elution using ethyl acetate in hexane (5 -30 %) on an open column. A pure compound was obtained with Rf = 0.61 in hexane/ethyl acetate (8:2 v/v) after repeated washing and recrystallization from methanol and coded Enac1. The pure compound was analyzed using IR, 1 H & 13 C NMR and GC-MS. Clinical isolates of Escherichia coli, Klebsiella pneumoniae, Salmonella typhi and Staphylococcus aureus were used to assess the antibacterial activity of the pure compound while its preliminary Cytotoxicity was evaluated using brine shrimp nauplii. Based on the spectroscopic data obtained and in comparison with literature, the isolated compound was identified as betulin. The minimum inhibitory concentration (MIC) of betulin ranged between 62.50 -250.00 µg/mL for all the four bacterial isolates in the study while its fifty percent lethal concentration (LC50) was 10.00 µg/mL. Significant Cytotoxicity with moderate antibacterial activity was observed. The study therefore justifies the existence of bioactive compounds in the stem bark of Entada africana and its use in traditional medicine.

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“…Betulin is a natural product, which is the main source of birch bark [ 43 ]. The potent biological activity of this compound is due to esterification, and various methods of esterification have been proposed to enhance its activity [ 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 ]. The anticancer activity of this compound toward human melanoma was reported decades ago [ 45 ].…”

Section: Resultsmentioning

confidence: 99%

“…Later, several studies have revealed that Betulin is not only melanoma-specific, but is also fairly active against many other cancer cell types [ 46 , 47 , 48 ]. The derivatives of Betulin have been explored for their significant properties like anti-bacterial [ 49 ], antimalarial [ 50 ], anti-inflammatory [ 51 ], anthelmintic activities [ 52 ] and anti-HIV [ 53 ]. Similarly, Noroleans are recognized as important chemical constituents of the family Lardizabalaceae, and Noroleanane triterpenoids have a wide range of bioactivities [ 54 , 55 , 56 ].…”

Section: Resultsmentioning

confidence: 99%

Computational Modeling of the Staphylococcal Enterotoxins and Their Interaction with Natural Antitoxin Compounds

Kurjogi

Satapute

Jogaiah

et al. 2018

IJMS

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Staphylococcus aureus is an opportunistic bacterium that produces various types of toxins, resulting in serious food poisoning. Staphylococcal enterotoxins (SEs) are heat-stable and resistant to hydrolysis by digestive enzymes, representing a potential hazard for consumers worldwide. In the present study, we used amino-acid sequences encoding SEA and SEB-like to identify their respective template structure and build the three-dimensional (3-D) models using homology modeling method. Two natural compounds, Betulin and 28-Norolean-12-en-3-one, were selected for docking study on the basis of the criteria that they satisfied the Lipinski’s Rule-of-Five. A total of 14 and 13 amino-acid residues were present in the best binding site predicted in the SEA and SEB-like, respectively, using the Computer Atlas of Surface Topology of Proteins (CASTp). Among these residues, the docking study with natural compounds Betulin and 28-Norolean-12-en-3-one revealed that GLN43 and GLY227 in the binding site of the SEA, each formed a hydrogen-bond interaction with 28-Norolean-12-en-3-one; while GLY227 residue established a hydrogen bond with Betulin. In the case of SEB-like, the docking study demonstrated that ASN87 and TYR88 residues in its binding site formed hydrogen bonds with Betulin; whereas HIS59 in the binding site formed a hydrogen-bond interaction with 28-Norolean-12-en-3-one. Our results demonstrate that the toxic effects of these two SEs can be effectively treated with antitoxins like Betulin and 28-Norolean-12-en-3-one, which could provide an effective drug therapy for this pathogen.

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Bioactive Betulin produced by marine Paecilomyces WE3-F

Cited by 12 publications

References 25 publications

Paecilomyces and Its Importance in the Biological Control of Agricultural Pests and Diseases

Paecilomyces and Its Importance in the Biological Control of Agricultural Pests and Diseases

Isolation, characterization and biological properties of betulin from Entada africana Guill. and Perr. (Mimosaceae).

Computational Modeling of the Staphylococcal Enterotoxins and Their Interaction with Natural Antitoxin Compounds

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