Bioactive borosilicate glass scaffolds: in vitro degradation and bioactivity behaviors

Abstract

Bioactive borosilicate glass scaffolds with the pores of several hundred micrometers and a competent compressive strength were prepared through replication method. The in vitro degradation and bioactivity behaviors of the scaffolds have been investigated by immersing the scaffolds statically in diluted phosphate solution at 37 degrees C, up to 360 h. To monitor the degradation progress of the scaffolds, the amount of leaching elements from the scaffolds were determined by ICP-AES. The XRD and SEM results reveal that, during the degradation of scaffolds, the borosilicate scaffolds converted to hydroxyapatite. The compressive strength of the scaffolds decreased during degradation, in the way that can be well predicted by the degradation products, or the leachates, from the scaffolds. MTT assay results demonstrate that the degradation products have little, if any, inhibition effect on the cell proliferation, when diluted to a certain concentration ([B] <2.690 and pH value at neutral level). The study shows that borosilicate glass scaffold could be a promising candidate for bone tissue engineering material.

Polymer/bioactive glass nanocomposites for biomedical applications: A review

“…The classical 45S5 bioactive glass composition universally known as Bioglass® (composition in wt%: 45% SiO 2 , 24.5% Na 2 O, 24.5% CaO and 6% P 2 O 5 ), for example, has approval of the US Food and Drug Administration (FDA) and is used in clinical treatments of periodontal diseases as bone filler as well as in middle ear surgery [2]. Other bioactive glass compositions contain no sodium or have additional elements incorporated in the silicate network such as fluorine, magnesium, strontium, iron, silver, boron, potassium or zinc [3][4][5][6][7][8][9].…”

Bioactive glass and glass-ceramic scaffolds for bone tissue engineering

“…The high amounts of Na 2 O and CaO, as well as the relatively high CaO/P 2 O 5 ratio make the glass surface highly reactive in physiological environments [11]. Other bioactive glass compositions developed over the years contain no sodium or have additional elements incorporated in the silicate network such as fluorine [13], magnesium [14,15], strontium [16][17][18], iron [19], silver [20][21][22][23], boron [24][25][26][27], potassium [28] or zinc [29,30]. Fabrication techniques for bioactive glasses include both traditional melting methods and sol-gel techniques [1, 3,4,10,[31][32][33], the latter are being highlighted elsewhere [34] and are not covered in this review.…”

Strontium borate glass: potential biomaterial for bone regeneration

“…However, the degradation of this silicon-based glass is highly timedependent, and the bulk material was reported to remain in the human body upto one year of implantation (Hamadouche et al 2001). As a result, borate glass, based on a B 2 O 3 network, is now showing potential in bone regeneration, owing to its complete conversion to apatite through a set of dissolutionprecipitation reactions similar in nature to those in 45S5 Bioglass (Huang et al 2006;Yao et al 2007;Liu et al 2009b). In particular, the mechanical strength of a scaffold based on a boron network former is significantly higher than that of the silicon network former in 45S5 Bioglass (Liu et al 2009a).…”