Bioactive Calcium Phosphate Coatings for Bone Implant Applications: A Review

Drevet, Richard; Fauré, J.; Benhayoune, Hicham

doi:10.3390/coatings13061091

Cited by 17 publications

(9 citation statements)

References 293 publications

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“…As is known [ 48 , 49 ], HAp and other Ca-P-based compounds can also enhance soft tissue repair and cell reactions around the implants due to the affinity between HAp and collagen stimulating collagen formation with suppression of inflammation and failure. Additionally, deposited HAp could change the surface morphology and increase its roughness that could stimulate the cell adhesion to a substrate resulting in biocompatibility enhancement [ 50 ]. Additionally, deposited HAp crystals and other Ca-P compounds are metabolized in the body to the Ca and P ions, which can be included into the structure of regenerated bone tissue [ 51 ] or collagen fibers [ 52 ].…”

Section: Discussionmentioning

confidence: 99%

Electrophoretic Deposition of Calcium Phosphates on Carbon–Carbon Composite Implants: Morphology, Phase/Chemical Composition and Biological Reactions

Skriabin,

Tsygankov,

Vesnin

et al. 2024

IJMS

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Despite a long period of application of metal implants, carbon–carbon medical composites are also widely used for bone defect prosthesis in surgery, dentistry, and oncology. Such implants might demonstrate excellent mechanical properties, but their biocompatibility and integration efficiency into the host should be improved. As a method of enhancing, the electrophoretic deposition of fine-dispersed hydroxyapatite (HAp) on porous carbon substrates might be recommended. With electron microscopy, energy dispersion X-ray and Raman spectroscopy, and X-ray diffraction, we found that the deposition and subsequent heat post-treatment (up to the temperature of 400 °C for 1 h) did not lead to any significant phase and chemical transformations of raw non-stoichometric HAp. The Ca/P ratio was ≈1.51 in the coatings. Their non-toxicity, cyto- and biocompatibility were confirmed by in vitro and in vivo studies and no adverse reactions and side effects had been detected in the test. The proposed coating and subsequent heat treatment procedures provided improved biological responses in terms of resorption and biocompatibility had been confirmed by histological, magnetic resonance and X-ray tomographic ex vivo studies on the resected implant-containing biopsy samples from the BDF1 mouse model. The obtained results are expected to be useful for modern medical material science and clinical applications.

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Section: Discussionmentioning

confidence: 99%

Electrophoretic Deposition of Calcium Phosphates on Carbon–Carbon Composite Implants: Morphology, Phase/Chemical Composition and Biological Reactions

Skriabin,

Tsygankov,

Vesnin

et al. 2024

IJMS

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“…The deposition parameters are shown in Table 1. The coatings were then dried in a horizontal position at room temperature for 72 h. After that, the samples were placed in a vacuum furnace (PROTHERM PC442, Ankara, Turkey) and heated for 120 min at 800 • C. Such post-deposition heat treatment is intended to increase the density of the coatings and improve the adhesive properties of the nHAp coatings [33,36]. The specimens were cooled in a furnace.…”

Section: Methodsmentioning

confidence: 99%

Study of Nanohydroxyapatite Coatings Prepared by the Electrophoretic Deposition Method at Various Voltage and Time Parameters

Malisz,

Świeczko-Żurek,

Olive

et al. 2024

Materials

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The aim of the work is to compare the properties of nanohydroxyapatite coatings obtained using the electrophoretic deposition method (EDP) at 10 V, 20 V, and 30 V, and with deposit times of 2 and 5 min. The primary sedimentation was used to minimize the risk of the formation of particle agglomerates on the sample surface. Evaluation of the coating was performed by using a Scanning Electron Microscope (SEM), Energy-Dispersive Spectroscopy (EDS), Atomic Force Microscopy (AFM), optical profilometer, drop shape analyzer, and a nanoscratch tester. All of the coatings are homogeneous without any agglomerates. When low voltage (10 V) was used, the coatings were uniform and continuous regardless of the deposition time. The increase in voltage resulted in the formation of cracks in the coatings. The wettability test shows the hydrophilic behavior of the coatings and the mean contact angle values are in the range of 20–37°. The coatings showed excellent adhesion to the substrate. The application of a maximum force of 400 mN did not cause delamination in most coatings. It is concluded that the optimal coating for orthopedic implants (such as hip joint implants, knee joint implants or facial elements) is obtained at 10 V and 5 min because of its homogeneity, and a contact angle that promotes osseointegration and great adhesion to the substrate.

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“…CaP materials exhibit a constraint resulting from weak chemical bonds when in contact with metallic surfaces [ 70 ]. Nevertheless, their high crystallinity, morphology, roughness, and wettability enhance their cell adhesion characteristics [ 71 ].…”

Section: Bioceramicsmentioning

confidence: 99%

Three-Dimensional Printing Methods for Bioceramic-Based Scaffold Fabrication for Craniomaxillofacial Bone Tissue Engineering

Sheikh,

Nayak,

Daood

et al. 2024

JFB

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Three-dimensional printing (3DP) technology has revolutionized the field of the use of bioceramics for maxillofacial and periodontal applications, offering unprecedented control over the shape, size, and structure of bioceramic implants. In addition, bioceramics have become attractive materials for these applications due to their biocompatibility, biostability, and favorable mechanical properties. However, despite their advantages, bioceramic implants are still associated with inferior biological performance issues after implantation, such as slow osseointegration, inadequate tissue response, and an increased risk of implant failure. To address these challenges, researchers have been developing strategies to improve the biological performance of 3D-printed bioceramic implants. The purpose of this review is to provide an overview of 3DP techniques and strategies for bioceramic materials designed for bone regeneration. The review also addresses the use and incorporation of active biomolecules in 3D-printed bioceramic constructs to stimulate bone regeneration. By controlling the surface roughness and chemical composition of the implant, the construct can be tailored to promote osseointegration and reduce the risk of adverse tissue reactions. Additionally, growth factors, such as bone morphogenic proteins (rhBMP-2) and pharmacologic agent (dipyridamole), can be incorporated to promote the growth of new bone tissue. Incorporating porosity into bioceramic constructs can improve bone tissue formation and the overall biological response of the implant. As such, employing surface modification, combining with other materials, and incorporating the 3DP workflow can lead to better patient healing outcomes.

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Bioactive Calcium Phosphate Coatings for Bone Implant Applications: A Review

Cited by 17 publications

References 293 publications

Electrophoretic Deposition of Calcium Phosphates on Carbon–Carbon Composite Implants: Morphology, Phase/Chemical Composition and Biological Reactions

Electrophoretic Deposition of Calcium Phosphates on Carbon–Carbon Composite Implants: Morphology, Phase/Chemical Composition and Biological Reactions

Study of Nanohydroxyapatite Coatings Prepared by the Electrophoretic Deposition Method at Various Voltage and Time Parameters

Three-Dimensional Printing Methods for Bioceramic-Based Scaffold Fabrication for Craniomaxillofacial Bone Tissue Engineering

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