Bioactive chromone constituents from &lt;em&gt;Vitex negundo&lt;/em&gt; alleviate pain and inflammation

Khan, Ajmal; Naz, Sadia; Farooq, Umar; Shahid, Muhammad; Ullah, Irfan; Ali, Iftikhar; Mabkhot, Yahia N.

doi:10.2147/jpr.s145551

Cited by 23 publications

(7 citation statements)

References 34 publications

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“…Enrichment of flavonoids, lignans, diterpenoids, iridoids and aromatic acids is its phytochemical characteristics. Its anti-oxidant, anticancer, anti-inflammatory, anti-diabetic and neuroprotective effects, as well as no toxic effects determine its extensive appliances in multiple diseases ( Khan et al, 2018 , Vinuchakkaravarthy, Kumaravel, Ravichandran, & Velmurugan, 2011 ).…”

Section: Gut Microbiota Is a Bridge Linking Pharmacological Effect Of...mentioning

confidence: 99%

Potential efficacy and mechanism of eight mild-natured and bitter-flavored TCMs based on gut microbiota: A review

Su,

Yang,

Zhao

et al. 2024

Chinese Herbal Medicines

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Section: Gut Microbiota Is a Bridge Linking Pharmacological Effect Of...mentioning

confidence: 99%

Potential efficacy and mechanism of eight mild-natured and bitter-flavored TCMs based on gut microbiota: A review

Su,

Yang,

Zhao

et al. 2024

Chinese Herbal Medicines

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“…Two new chromone derivatives were found in V . negundo L., identified as methyl 3-(2-(5-hydroxy-6-methoxy-4-oxo-4 H -chromen-2-yl)ethylbenzoate ( 160 ) and 3-(1-hydroxy-2-(5-hydroxy-6-methoxy-4-oxo-4 H -chromen-2-yl)ethylbenzoic acid ( 161 ) [ 135 ]. In mice, these isolated compounds were examined for antinociceptive action in an abdomen constriction assay with acetic acid and paw oedema assay with carrageenan showing anti-inflammatory activity.…”

Section: Secondary Metabolites Isolated From Vitex ...mentioning

confidence: 99%

Traditional Medicinal Uses, Phytochemistry, Biological Properties, and Health Applications of Vitex sp.

Kamal

Asni

Rozlan

et al. 2022

Plants

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The genus Vitex is also known as a chaste tree, in which it is a large shrub native to the tropical and subtropical regions of the world. A diverse range of species is distributed throughout Southern Europe, the Mediterranean, and Central Asia. The Vitex tree, including its leaves and fruits, has been used for herbal remedies in the form of pastes, decoctions, and dried fruits since ancient times. This article aimed to prepare a comprehensive review of traditional uses and secondary metabolites derived from Vitex sp., including the chemical compounds, biological activities, application of Vitex in human clinical trials, toxicology and safety, marketed products, and patents. The scientific findings were obtained using a number of search engines and databases, including Google Scholar, PMC, and ScienceDirect. Vitex species are well known in pharmacology to have medicinal values, such as anti-inflammatory, antibacterial, antifungal, antimicrobial, antioxidant, and anticancer properties. Previous studies reported that some species are proven to be effective in treating diseases, such as diabetes, and improving female health. A total of 161 compounds from different Vitex species are reported, covering the literature from 1982 to 2022. A chemical analysis report of various studies identified that Vitex exhibited a wide range of phytoconstituents, such as iridoid, diterpenoid, ecdysteroid, and flavonoid and phenolic compounds. Apart from that, the review will also discuss the application of Vitex in human clinical trials, toxicology and safety, marketed products, and patents of the genus. While the extracts of the genus have been made into many commercial products, including supplements and essential oils, most of them are made to be used by women to improve menstrual conditions and relieve premenstrual syndrome. Among the species, Vitex agnus-castus L. is the only one that has been reported to undergo clinical trials, mainly related to the use of the genus for the treatment of mastalgia, menstrual bleeding problems, amenorrhea, menorrhagia, luteal insufficiency, and premenstrual syndrome. Overall, the review addresses recent therapeutic breakthroughs and identifies research gaps that should be explored for prospective research work.

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“…Vitex negundo, also known as Nirgundi is included in the Verbenaceae family. Vitex negundo has enormous medicinal value, and the leaf extract has been utilized in Ayurvedic medicine as an anti-inflammatory, analgesic, and anti-itching agent (11). This plant is widely grown in America, Europe, Asia, and West Indies and is widespread in Indo-Malaysia.…”

Section: Introductionmentioning

confidence: 99%

Optimization and Evaluation of Anti-Inflammatory Herbal Emulgel loaded with Vitex Negundo for Enhanced Permeation

Keerthana¹,

Dubey²,

Mahadev³

et al. 2023

IJAM

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The use of conventional drugs for the treatment of pain and inflammation has largely resulted in various side effects. These challenges have triggered the search for alternative therapy such as herbal medication that may serve as a safe, effective, and alternate treatment approach to managing pain and inflammation. Vitex negundo, a potential lipophilic molecule, possesses limited solubility and permeability. Emulgels are either water-in-oil or oil-in-water type emulsions, mixed with a gelling agent to form a gel for the delivery of lipophilic active ingredients. Therefore the current study is undertaken for the effective delivery of vitex negundo locally in the form of oil-in-water emulgel for improving solubility and permeability. The emulgel was formulated from carbopol 934 with vitex negundo in mineral oil emulsion using tween 80 (surfactant), and triethanolamine (co-surfactant). The formulations were optimized using the design of experiment software. The optimized emulgel formulation containing Smix (tween 80 and triethanolamine) ratio of 61.90, mineral oil 50.58%, and carbopol 934 3% showed a pH of 6.5±0.3, a viscosity of 17793 – 939 cps, and spreadability of 7.07 g.cm/s. Data from in-vitro and ex-vivo diffusion studies demonstrated improved permeability properties. The stability of the optimized emulgel formulation was additionally examined at ambient temperature for 28 days. The emulgel remained stable for 28 days. Based on the overall results we can conclude that emulgel can be a promising and suitable formulation for the application of vitex negundo.

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Bioactive chromone constituents from <em>Vitex negundo</em> alleviate pain and inflammation

Cited by 23 publications

References 34 publications

Potential efficacy and mechanism of eight mild-natured and bitter-flavored TCMs based on gut microbiota: A review

Potential efficacy and mechanism of eight mild-natured and bitter-flavored TCMs based on gut microbiota: A review

Traditional Medicinal Uses, Phytochemistry, Biological Properties, and Health Applications of Vitex sp.

Optimization and Evaluation of Anti-Inflammatory Herbal Emulgel loaded with Vitex Negundo for Enhanced Permeation

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