Bioactive Coating on Ti Alloy with High Osseointegration and Antibacterial Ag Nanoparticles

Abstract

Titanium alloys have advanced mechanical properties jointly with high biocompatibility that make them eminently suitable for biomedical applications such as dental and orthopedic implants. Improvement in their osseointegration with human bone can be achieved by the development of hydroxyapatite (HAp) on a Ti alloy surface using different methods of deposition. However, plasma electrolytic oxidation (PEO) treatment has been found to be one of the most promising techniques, due to the formation of high bonding between the bone and the Ti surface. Along with this high bonding, an antibacterial ability of the surface to prevent bacterial infection is also essential. Silver, which is a widely applicable antibacterial agent, was used in this work. First, a titanium oxide coating containing calcium and phosphorus and Ag nanoparticles was formed by PEO treatment. Then, Ti alloy was subjected to hydrothermal treatment to ensure a crystalline formation of HAp. Morphology and phase composition investigations detected the presence of HAp crystals in the coating along with antibacterial agents of silver nanoparticles. The biocompatibility and bioactivity of the created coating were examined by contact angle (CS) measurement and electrochemical impedance spectroscopy (EIS). It was shown that the coating was extensively grown after exposure of the alloy to simulated body fluid (SBF) solution for 7 days with no effect on the Ag nanoparticles. An antibacterial test using Staphylococcus aureus and Escherichia coli revealed that the coating containing Ag nanoparticles has more significant antibacterial effectiveness compared to a coating that does not contain silver.

Osteoconductive and Osteoinductive Surface Modifications of Biomaterials for Bone Regeneration: A Concise Review

“…Thermal spraying methods have been commonly applied to modify ceramic or metallic substrates [34]. Principal thermal plasma spraying techniques include: atmospheric plasma spraying, high velocity suspension flame spraying, suspension plasma spraying, solution precursors plasma spraying, flame spraying [19,34,83], and plasma electrolytic oxidation [84,85]. Plasma surface modification technologies may not only be applied for metallic implants, but also for polymeric biomaterials.…”

Biofunctional Elements Incorporated Nano/Microstructured Coatings on Titanium Implants with Enhanced Osteogenic and Antibacterial Performance

“…Morphology and composition of MAO coatings with nano/micropores depend on the composition of the electrolyte and voltage. [18] Various bioinorganic elements, such as Zn, [19] Cu, [20][21][22] Si, [22][23][24] and Ag, [23,25,26] have been individually or jointly introduced into the coatings on Ti surfaces via MAO methods. In the deposition process, chelating agents, such as d-gluconate, [20][21][22] acetate acid, [25] and oxalic acid, [26] are commonly used in order to avoid metal salts precipitation and enhance ion migration toward the anode, ultimately prompt ions deposition.…”

Antibacterial Hybrid Hydrogels

“…synthesized a titanium oxide coating modified with calcium and phosphorus and Ag NPs using plasma electrolytic oxidation (PEO) method, and then obtained a hydroxyapatite‐titania coating decorated with Ag NPs by hydrothermal treatment. [ 29 ] The prepared coating showed good antibacterial properties due to the action of Ag + . In addition to Ag + , Cu 2+ and Zn 2+ are also widely used in antibacterial field.…”