Bioactive compounds and pigments from cyanobacteria: Applications in the pharmaceutical industry

Sitther, Viji; Wyatt, LaDonna; Jones, Christian; Yalçın, Yavuz

doi:10.1016/b978-0-323-91202-0.00009-9

Cited by 3 publications

(1 citation statement)

References 120 publications

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“…These microbes offer a sustainable avenue for reducing atmospheric CO 2 levels, leveraging their fast growth rates and wide metabolic potential to convert CO 2 into useful biomass, thereby contributing to the development of bioenergy and bioproducts that support carbon-neutral objectives [ 7 ]. Moreover, a recent review by Sitther et al [ 8 ] highlights the potential of cyanobacteria not only as a renewable energy source but also their significant role in industrial biotechnology, particularly in generating value-added bioproducts, bioplastics, and pharmaceuticals.…”

Section: Introductionmentioning

confidence: 99%

Impact of Zero-Valent Iron Nanoparticles and Ampicillin on Adenosine Triphosphate and Lactate Metabolism in the Cyanobacterium Fremyella diplosiphon

Yalcin,

Aydin,

Sitther

2024

Microorganisms

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In cyanobacteria, the interplay of ATP and lactate dynamics underpins cellular energetics; their pronounced shifts in response to zero-valent iron (nZVI) nanoparticles and ampicillin highlight the nuanced metabolic adaptations to environmental challenges. In this study, we investigated the impact of nZVIs and ampicillin on Fremyella diplosiphon cellular energetics as determined by adenosine triphosphate (ATP) content, intracellular and extracellular lactate levels, and their impact on cell morphology as visualized by transmission electron microscopy. While a significant increase in ATP concentration was observed in 0.8 mg/L ampicillin-treated cells compared to the untreated control, a significant decline was noted in cells treated with 3.2 mg/L nZVIs. ATP levels in the combination regimen of 0.8 mg/L ampicillin and 3.2 mg/L nZVIs were significantly elevated (p < 0.05) compared to the 3.2 mg/L nZVI treatment. Intracellular and extracellular lactate levels were significantly higher in 0.8 mg/L ampicillin, 3.2 mg/L nZVIs, and the combination regimen compared to the untreated control; however, extracellular lactate levels were the highest in cells treated with 3.2 mg/L nZVIs. Visualization of morphological changes indicated increased thylakoid membrane stacks and inter-thylakoidal distances in 3.2 mg/L nZVI-treated cells. Our findings demonstrate a complex interplay of nanoparticle and antibiotic-induced responses, highlighting the differential impact of these stressors on F. diplosiphon metabolism and cellular integrity.

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Section: Introductionmentioning

confidence: 99%

Impact of Zero-Valent Iron Nanoparticles and Ampicillin on Adenosine Triphosphate and Lactate Metabolism in the Cyanobacterium Fremyella diplosiphon

Yalcin,

Aydin,

Sitther

2024

Microorganisms

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Cyanobacterial Bioactive Compounds: Synthesis, Extraction, and Applications

Khan,

Akhlaq,

Rasool

et al. 2024

Pharmaceutical and Nutraceutical Potential of Cyanobacteria

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Role of Algal-derived Bioactive Compounds in Human Health

Mishra

Tripathi

Dubey

et al. 2024

BIOT

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Algae is emerging as a bioresource with high biological potential. Various algal strains have been used in traditional medicines and human diets worldwide. They are a rich source of bioactive compounds like ascorbic acid, riboflavin, pantothenate, biotin, folic acid, nicotinic acid, phycocyanins, gamma-linolenic acid (GLA), adrenic acid (ARA), docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), etc. Beta-carotene, astaxanthin, and phycobiliproteins are different classes of pigments that are found in algae. They possess antioxidant, anti-inflammatory and anticancer properties. The sulfur-coated polysaccharides in algae have been used as an anticancer, antibacterial, and antiviral agent. Scientists have exploited algal-derived bioactive compounds for developing lead molecules against several diseases. Due to the surge in research on bioactive molecules from algae, industries have started showing interest in the large-scale production of bioactive compounds having applications in sectors like pharmaceuticals, food, and beverage. In the food industry, algae are used as a thickening, gelling, and stabilizing agent. Due to their gelling and thickening characteristics, the most valuable algae products are macro-algal polysaccharides, such as agar, alginates, and carrageenan. The high protein, lipid, and nutrient content in microalgae makes it a superfood for aquaculture. The present review aims to describe various non-energy-based algae applications in pharmaceuticals, food and beverage, cosmetics, and nutraceuticals. This review attempts to analyze information on algal-derived drugs that have shown better potential and reached clinical trials.

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Bioactive compounds and pigments from cyanobacteria: Applications in the pharmaceutical industry

Cited by 3 publications

References 120 publications

Impact of Zero-Valent Iron Nanoparticles and Ampicillin on Adenosine Triphosphate and Lactate Metabolism in the Cyanobacterium Fremyella diplosiphon

Impact of Zero-Valent Iron Nanoparticles and Ampicillin on Adenosine Triphosphate and Lactate Metabolism in the Cyanobacterium Fremyella diplosiphon

Cyanobacterial Bioactive Compounds: Synthesis, Extraction, and Applications

Role of Algal-derived Bioactive Compounds in Human Health

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