Bioactive Compounds for Skin Health: A Review

Michalak, Monika; Pierzak, Monika; Krêcisz, Beata; Suliga, Edyta

doi:10.3390/nu13010203

Cited by 175 publications

(142 citation statements)

References 217 publications

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“…Se is an essential trace element that participates in antioxidant defense and redox state regulation [119]. Some authors have shown that Se delays skin aging by protecting keratinocyte stem cells against UVAinduced cytotoxicity [120]. Supplementation with Se resulted in partial improvement in OLP patients; the improvement was similar with both topical and systemic Se and similar to that obtained with topical corticosteroids.…”

Section: Nutraceuticals As Antioxidantsmentioning

confidence: 81%

Therapies with Antioxidant Potential in Psoriasis, Vitiligo, and Lichen Planus

et al. 2021

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Oxidative stress plays an important pathogenetic role in many chronic inflammatory diseases, including those of dermatological interest. In particular, regarding psoriasis, vitiligo, and lichen planus, excess reactive oxygen species and a decline in endogenous antioxidant systems are observed. In this regard, treatments with antioxidant properties could be appropriate therapeutic options. To date, clinical trials in dermatology on these treatments are limited. We reviewed the available studies on the efficacy of antioxidant therapies in psoriasis, vitiligo, and lichen planus. The role of herbal derivatives, vitamins, and trace elements was analyzed. The antioxidant properties of conventional therapies were also evaluated. Data from the literature suggest that antioxidants might be useful, but available studies on this topic are limited, heterogeneous, not completely standardized, and on small populations. Furthermore, in most cases, antioxidants alone are unable to induce significant clinical changes, except perhaps in mild forms, and must be used in conjunction with standard drug treatments to achieve measurable results. Further studies need to be conducted, considering larger populations and using internationally validated scales, in order to compare the results and clinical efficacy.

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Section: Nutraceuticals As Antioxidantsmentioning

confidence: 81%

Therapies with Antioxidant Potential in Psoriasis, Vitiligo, and Lichen Planus

et al. 2021

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“…It is emphasized that Cu stimulates the proliferation of skin fibroblasts. It is a cofactor of superoxide dismutase and also prevents lipid peroxidation and oxidative damage to cell membranes [71].…”

Section: Discussionmentioning

confidence: 99%

Intake of Antioxidant Vitamins and Minerals in Relation to Body Composition, Skin Hydration and Lubrication in Young Women

et al. 2021

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The aim of this study was to estimate the consumption of selected dietary components with antioxidant properties, undertake body composition analysis, assess skin hydration and lubrication, and establish the relationships between the above parameters. The study was carried out on 172 young women. The consumption of ingredients (vitamins A, C, D and E, and Cu, Mn, Zn) was assessed using the Diet 6.0 program, body composition was assessed using electrical bioimpedance and skin hydration and lubrication were assessed using the corneometric and sebumetric methods, respectively. About one-third of students showed insufficient consumption of vitamin C, vitamin E and zinc, while about 99% showed insufficient vitamin D levels. The highest degree of hydration was observed in the areas of the eyelids, neckline and chin. The greatest amount of sebum was found in the area of the nose and forehead. Low positive correlations between hydration or lubrication and Cu, vitamin A and vitamin E were observed. In conclusion, to properly moisturize and lubricate the skin, young women should eat products that are rich in ingredients with antioxidant properties, in particular fat-soluble vitamins A and E, but also copper.

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“…In addition, minerals such as copper, zinc, and selenium also play important roles in skin health [ 19 , 153 , 154 ]. They are cofactors in enzymatic reactions during collagen crosslinking and necessary elements for epidermal proliferation and keratinocyte differentiation [ 154 , 155 ].…”

Section: Efficacy and Mechanisms Of Dietary Components In Mitigating Skin Photoaging: Animal And Human Evidencementioning

confidence: 99%

Boosting the Photoaged Skin: The Potential Role of Dietary Components

et al. 2021

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Skin photoaging is mainly induced by ultraviolet (UV) irradiation and its manifestations include dry skin, coarse wrinkle, irregular pigmentation, and loss of skin elasticity. Dietary supplementation of nutraceuticals with therapeutic and preventive effects against skin photoaging has recently received increasing attention. This article aims to review the research progress in the cellular and molecular mechanisms of UV-induced skin photoaging. Subsequently, the beneficial effects of dietary components on skin photoaging are discussed. The photoaging process and the underlying mechanisms are complex. Matrix metalloproteinases, transforming growth factors, skin adipose tissue, inflammation, oxidative stress, nuclear and mitochondrial DNA, telomeres, microRNA, advanced glycation end products, the hypothalamic–pituitary–adrenal axis, and transient receptor potential cation channel V are key regulators that drive the photoaging-associated changes in skin. Meanwhile, mounting evidence from animal models and clinical trials suggests that various food-derived components attenuate the development and symptoms of skin photoaging. The major mechanisms of these dietary components to alleviate skin photoaging include the maintenance of skin moisture and extracellular matrix content, regulation of specific signaling pathways involved in the synthesis and degradation of the extracellular matrix, and antioxidant capacity. Taken together, the ingestion of food-derived functional components could be an attractive strategy to prevent skin photoaging damage.

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Bioactive Compounds for Skin Health: A Review

Cited by 175 publications

References 217 publications

Therapies with Antioxidant Potential in Psoriasis, Vitiligo, and Lichen Planus

Therapies with Antioxidant Potential in Psoriasis, Vitiligo, and Lichen Planus

Intake of Antioxidant Vitamins and Minerals in Relation to Body Composition, Skin Hydration and Lubrication in Young Women

Boosting the Photoaged Skin: The Potential Role of Dietary Components

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