Bioactive compounds from endemic plants of Southwest Portugal: Inhibition of acetylcholinesterase and radical scavenging activities

Tavares, Lucélia; Tyagi, Meenu; Barata, David; Serra, Ana Teresa; Duarte, Isabel Catarina; Duarte, Ricardo; Feliciano, Rodrigo P.; Bronze, Maria Rosário; Espírito-Santo, Dalila; Ferreira, Ricardo B.; Santos, Cláudia N.

doi:10.3109/13880209.2011.596209

Cited by 15 publications

(19 citation statements)

References 30 publications

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“…Of the considered peaks registered from the chromatographic profile at 280 nm, hydroxicinammic acids derivatives (peaks 3, 7 and 8), flavones (peak 4 and 6), simple phenolic acids (peak 1), flavonol (peak 5) and coumarin (peak 2) were detected. In accordance with these results, also ferulic acid and its derivatives were the principal components identified in S. impressa hydroethanolic extracts by HPLC-DAD (Tavares et al, 2011).…”

Section: Pef Compositionsupporting

confidence: 87%

“…Although not directly comparable, S. rosmarinifolia presented a significant free radical scavenging activity among 57 extractsof 54 plant species of 30 families (Nikolova et al, 2011). Interestingly, S. semidentata presents higher content in phenolics and flavonoids comparing with S. impressa, also a Portuguese endemic plant from the Comporta/Galé site, in Southwestern Portugal (Tavares et al, 2011) (namely 23.16 ± 0.49 vs. 4.36 ± 0.32 mg GAE g −1 dw, and 11.86 ± 0.12 vs. 1.13 ± 0.07 mg CE g −1 dw). S. impressa presented a lower level of these phytochemical that reflects in a much lower antioxidant capacity for peroxyl radical than S. semidentata, here characterized for the first time.…”

Section: Resultsmentioning

confidence: 97%

“…The antioxidant potential of other plants of the genus Santolina had already been described. Nikolova et al (2011) have evaluated Santolina rosmarinifolia L. (herba) and Tavares et al (2011) evaluated Santolina impressa. Although not directly comparable, S. rosmarinifolia presented a significant free radical scavenging activity among 57 extractsof 54 plant species of 30 families (Nikolova et al, 2011).…”

Section: Resultsmentioning

confidence: 99%

“…AChE inhibition of S. semidentata hydroethanolic extract and PEF was determined in a ninety six microtiter well plate, based on Ellman's reaction (Ellman et al, 1961), according with (Tavares et al, 2011). Effect on AChE activity was calculated as an inhibition percentage (%) of the maximum activity (registered on control wells without inhibitor).…”

Section: Acetylcholinesterase (Ache) Inhibitory Assaymentioning

confidence: 99%

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Chemical characterization and bioactivity of phytochemicals from Iberian endemic Santolina semidentata and strategies for ex situ propagation

Gomes

Pimpão

Figueira

et al. 2015

Industrial Crops and Products

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a b s t r a c tAsteraceae family members are well-known for their medicinal potential, comprising several properties that make them unique among plants. Here we focus on Santolina semidentata, an endemic plant from the Iberian Peninsula, not yet described for its medicinal properties. Phytochemical characterization of S. semidentata was performed, concerning total phenol content, flavonoid content, antioxidant capacity, HPLC-DAD profile, acetylcholinesterase inhibitory capacity, cytotoxicity and neuroprotective effect in a human neurodegeneration cell model. Moreover, essential oil composition and antifungal activity were also analised. This oil might be useful for therapeutical purposes, particularly in the treatment of dermatophytosis. S. semidentata potential for neuroprotection was revealed by acetylcholinesterase inhibitory capacity and also by an effective protective effect in human neuronal cells. Furthermore, different seed conservation protocols, as well as successful in vitro propagation were established which may be useful when integrated in a broad strategy for the conservation of these endemic plants and their sustainable use for potential biotechnological applications. The results presented here greatly contribute to value this species regarding its potential as a source of phytochemicals with prospective neuroprotective health benefits, either as alternative neuroprotective drugs or as leads for synthetizing more effective molecules.

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Section: Pef Compositionsupporting

confidence: 87%

Section: Resultsmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 99%

Section: Acetylcholinesterase (Ache) Inhibitory Assaymentioning

confidence: 99%

See 2 more Smart Citations

Chemical characterization and bioactivity of phytochemicals from Iberian endemic Santolina semidentata and strategies for ex situ propagation

Gomes

Pimpão

Figueira

et al. 2015

Industrial Crops and Products

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“…[30] With these results, also ferulic acid and its derivatives were the principal components identified in the hydroethanolic extract of S. impressa. [31] The important constituents, considered as chemical markers of Santolina species were not detected in our work suggesting a high chemical differentiation of S. africana probably because of its specific position as an endemic plant which could play an important role in flavonoid diversity. [32] Today, there are increasing studies to search for novel as α-amylase and α-glucosidase inhibitors from natural sources expected to be effective and safe.…”

Section: Antioxidant Activitymentioning

confidence: 53%

Chemical composition and bioactivities of the polyphenolic-rich extract of Ormenis africana Jord. and Fourr

Béjaoui

Boulila

Salem

et al. 2016

International Journal of Food Properties

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Ormenis africana is an endemic North African species used in folk medicine because of its hypoglycemic property. In this study, the α-amylase and α-glucosidase inhibition and antioxidant activities of the polyphenolic-rich extract from O. africana were determined. The chemical composition was made using liquid chromatography with photodiode array and electrospray ionization mass spectrometry method and the identification of phenolics was assessed by comparing their retention times and ultraviolet and mass spectra with those of the standards and/or reported in the literature. The total phenolic content was estimated by the Folin-Ciocalteu method. The antidiabetic potential was estimated by the determination of α-amylase and α-glucosidase inhibition in vitro. Four assays were used for the evaluation of antioxidant activity of the extracts. Seventeen phenolic compounds were detected. The major peaks are chlorogenic acid, 5-O-di-caffeoylquinic acid, and apigenin and luteolin derivatives. The polyphenolic-rich extract showed remarkable α-amylase and α-glucosidase inhibition activity in a concentration dependent manner. Furthermore, the extract also demonstrated high antioxidant activities. O. africana can serve as a potential natural source for the development of a novel α-amylase and α-glucosidase inhibitory agents against diabetic complications. ARTICLE HISTORY

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Novel bis-ureido-substituted sulfaguanidines and sulfisoxazoles as carbonic anhydrase and acetylcholinesterase inhibitors

et al. 2022

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Bioactive compounds from endemic plants of Southwest Portugal: Inhibition of acetylcholinesterase and radical scavenging activities

Cited by 15 publications

References 30 publications

Chemical characterization and bioactivity of phytochemicals from Iberian endemic Santolina semidentata and strategies for ex situ propagation

Chemical characterization and bioactivity of phytochemicals from Iberian endemic Santolina semidentata and strategies for ex situ propagation

Chemical composition and bioactivities of the polyphenolic-rich extract of Ormenis africana Jord. and Fourr

Novel bis-ureido-substituted sulfaguanidines and sulfisoxazoles as carbonic anhydrase and acetylcholinesterase inhibitors

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