Bioactive Compounds from Food and Its By-products: Current Applications and Future Perspectives

A Comprehensive Analytical Review of Polyphenols: Evaluating Neuroprotection in Alzheimer’s Disease

“…Nonetheless, in recent years, there has been increased recognition of food bio-residues as sources of phenolic compounds, notably, horticultural residues, which encompass all the discarded parts of fruits and vegetables during the different stages of the food supply chain [ 8 , 37 ]. Accordingly, polyphenols have already been identified from the main by-products generated in powerful agri-food manufacturing industries, which include apple pomace, banana peel, coffee pulp and spent coffee grain, grape skins, stems and seeds, olive oil mill, onion skin, and rice bran, to name but a few [ 38 ]. On top of that, the use and valorization of agri-food bio-residues as polyphenol sources to be transformed into added-value products emerges as a sustainable circular economy strategy, contributing to the minimization of environmental constrains triggered by food waste disposal, as to the attainment of economic and social benefits [ 37 , 39 , 40 ].…”

“…The particular nature and functionality of phenolic compounds has captured the attention of nutritionists, researchers, and manufacturers in various industrial sectors. In particular, the focus has been centered on the potent antioxidant properties of polyphenols and their preventive role in various non-communicable diseases related to oxidative stress, such as metabolic syndrome and diabetes, cardiovascular diseases, neurodegenerative disorders, or cancer [ 14 , 38 ]. In such a way, polyphenols serve as potent antioxidants in a multitude of chemical oxidation systems.…”

“…Further to this, other biological activities have been described in numerous in vitro and in vivo assays, providing anti-inflammatory, anti-hypertensive, antibacterial, antiproliferative, and neuroprotective activity, only to mention a few [ 14 , 38 , 42 , 43 ]. This has precipitated a myriad of intended utilizations spanning a diverse array of industrial domains, encompassing pharmaceuticals, agri-food, nutraceutical, cosmetics, and textiles.…”