Bioactive Compounds from Combretum erythrophyllum

Schwikkard, Sianne; Bin, Zhou; Glass, Thomas E.; Sharp, Jessica L.; Mattern, Michael R.; Johnson, Randall K.; Kingston, David G. I.

doi:10.1021/np9904410

Cited by 33 publications

(13 citation statements)

References 9 publications

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“…The aqueous extract causes mutations in the meiotic stage of Drosophila melanogaster [ 86 ]. The methanol, dichloromethane and acetate extracts of C. erythrophyllum showed bioactivity in a yeast-based microtiter assay for DNA-damaging agents [ 91 ] ( Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

Bioactivities of the Genus Combretum (Combretaceae): A Review

et al. 2012

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The Combretaceae is a large family of herbs, shrubs and trees, comprising about 20 genera and 600 species with tropical distribution around the globe and centers of diversity in Africa and Asia. Some Combretum species are extensively used in traditional medicine against inflammation, infections, diabetes, malaria, bleeding, diarrhea and digestive disorders and others as a diuretic. The present work is a literature survey of Combretum species that have been evaluated for their ability to exert biological activities. A total number of 36 Combretum species are discussed with regard to plant parts used, component tested and bioassay models. This review is of fundamental importance to promoting studies on Combretum species, thereby contributing to the development of new therapeutic alternatives that may improve the health of people suffering from various health problems.

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Section: Resultsmentioning

confidence: 99%

Bioactivities of the Genus Combretum (Combretaceae): A Review

et al. 2012

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“…The long-range correlation observed between H-1′′ (δH 5.22) and C-3 (δC 135.3) indicated the glucosyl group was located at C-3. The glucosyl group should be in a β-configuration due to the coupling constant value of H-1′′ (J = 7 Hz) 13 and by comparing the 1 H and 13 C NMR data with those of glucose 11 . Furthermore, this was also confirmed by ROESY correlations of H-1′′ with H-3′′ and H-5′′, H-2′′ with H-4′′.…”

Section: Resultsmentioning

confidence: 99%

A New Flavone from Flower Buds of Rosa rugosa

Qin¹,

Yang²,

Xia³

et al. 2014

Asian J. Chem.

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Rosa rugosa Thunb. (Rosaceae) is a common ornamental flower distributed in the temperate regions of eastern Asia and widely cultivated in the Yunnan Province 1,2. The petals and buds of R. rugosa are often used as food, incense and as Chinese medicinal materials for the treatment of stomachache, diarrhea and gynecological problems 3. Previous studies have shown the presence of tannins 4 , terpenoids 5-7 and flavonoids 8,9 in this genus. Anti-inflammatory and cytotoxic activities have been observed with selected chemical ingredients isolated from R. rugosa 7,10. Previous studies in our laboratories on this plant have led to the isolation of three new aurones that possess anti-HIV-1 and cytotoxic properties 9. Continuing the effort to search for novel and bioactive metabolites from medicinal plants, we now report the isolation and characterization of a new flavone (1). In this paper, the structure elucidation of 1 and its biological evaluation are described. EXPERIMENTAL Optical rotations were measured with a Horiba SEPA-300 polarimeter. UV spectra were obtained using a Shimadzu UV-2401A spectrophotometer. A Tenor 27 spectrophotometer was used for scanning IR spectra. 1D-and 2D NMR spectroscopic data were recorded on a DRX-500 NMR spectrometer with TMS as internal standard. Chemical shifts (δ) are expressed in ppm with reference to the TMS signal. HRESIMS was performed on a VG Autospec-3000 spectrometer. Semipreparative HPLC was performed on a Shimadzu LC-8A preparative liquid chromatograph with Zorbax PrepHT GF

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“…The mutant strain, RS321NpRAd52, used in this assay, is deficient in recombination repair (RAD 52) and topoisomerase I, but the strain carries a plasmid containing the RAD 52 repair pathway gene under the control of galactose promoter [4]. The RS321pRAD52 yeast was split into two separate sterile flasks.…”

Section: Bioassaymentioning

confidence: 99%

“…At this point, the growth inhibition was calculated by using the formula 1 À (ODtest well À ODblank)/ (ODplate À ODblank). Any agent that was cytotoxic to the yeast in the RS321pRAD52 glucose and RS321NYCp50 galactose plate (>65% inhibition) but was not cytotoxic in the RS321pRAD52 galactose plate (<35% inhibition) was considered an active agent [4]. Camptothecin was used as a positive control.…”

Section: Bioassaymentioning

confidence: 99%

“…A previous study of steroids and terpenoids compounds of other Ajuga species in Turkey, Ajuga relicta, was reported in the literature [3]. In our systematic search for potential anti-cancer agents from plants, we have tested over the 250 plants of flora of Turkey, against RS321NYCp50 grown on galactose, RS321NpRAD52 on galactose and RS321NpRAD52 on glucose [4]. By the bioassay-guided fractionation, DNA damaging activities of Turkish endemic plant Ajuga postii and isolation of an iridoid glucoside reptoside (1) are reported in this study.…”

Section: Introductionmentioning

confidence: 99%

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DNA damaging activities of methanol extract of Ajuga postii and iridoid glucoside reptoside

Gören

Bin

Topçu

et al. 2005

Natural Product Research

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An iridoid glucoside reptoside (1) has been isolated as a DNA damaging active agent by bioassay-guided fractionation of the methanol extract of Ajuga postii. Furthermore, from the acetone extract of A. postii two known triterpenic compounds ursolic acid, alpha-amyrin and two steroidal compounds (24S)-24-ethylcholesta-5,25-dien-3beta-ol and beta-sitosterol were isolated. Their structures were elucidated based on 1D and 2D NMR techniques and mass data.

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Bioactive Compounds from Combretum erythrophyllum

Cited by 33 publications

References 9 publications

Bioactivities of the Genus Combretum (Combretaceae): A Review

Bioactivities of the Genus Combretum (Combretaceae): A Review

A New Flavone from Flower Buds of Rosa rugosa

DNA damaging activities of methanol extract of Ajuga postii and iridoid glucoside reptoside

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