Bioactive Compounds from Marine Bacteria and Fungi

Debbab, Abdessamad; Aly, Amal H.; Lin, Wen Han; Proksch, Peter

doi:10.1111/j.1751-7915.2010.00179.x

Cited by 319 publications

(200 citation statements)

References 74 publications

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“…1 An extensive number of studies that mainly focused on terrestrial microorganisms as drug discovery resources demonstrated that they produce a number of structurally unique and biologically active compounds including antibiotics, anticancer agents and immunomodulators. 2,3 We recently became interested in poorly studied resources including marinederived microorganisms. In the course of our search for new bioactive compounds from marine microorganisms, we have identified novel and unique compounds such as seriniquinone 4 (an anticancer agent against melanoma cells) and graphiumins 5,6 (inhibitors of yellow pigment production in methicillin-resistant Staphylococcus aureus).…”

Section: Introductionmentioning

confidence: 99%

Isomethoxyneihumicin, a new cytotoxic agent produced by marine Nocardiopsis alba KM6-1

et al. 2016

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A new cytotoxic agent designated isomethoxyneihumicin (1 and 2), a mixture of lactam-lactim tautomers, was isolated along with methoxyneihumicin (3) from the culture broth of the marine Nocardiopsis alba KM6-1. The structures of 1 and 2 were elucidated in spectroscopic analyses (1D and 2D NMR data, and ROESY correlations). Isomethoxyneihumicin (15.0 μM) and 3 (15.0 μM) arrested the cell cycle of Jurkat cells at the G2/M phase (66 and 67%) in 12 h. Isomethoxyneihumicin and 3 exhibited cytotoxicity against Jurkat cells with IC 50 values of 6.98 and 30.5 μM in 20 h, respectively. These results strongly suggest that isomethoxyneihumicin and 3 exhibit cytotoxicity against Jurkat cells by inhibiting the cell cycle at the G2/M phase.

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Section: Introductionmentioning

confidence: 99%

Isomethoxyneihumicin, a new cytotoxic agent produced by marine Nocardiopsis alba KM6-1

et al. 2016

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“…If the three-dimensional structures could not be downloaded, they were created using MarvinSketch with the minimization parameters of the MMFF94 force field and a strict optimization limit. Various marine fungi bioactive compounds, whether known specifically as anticancer or not, were included in the marine database, resulting in 268 structures that were downloaded from PubChem and ChemSpider or created using MarvinSketch [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33].…”

Section: Preparation Of the Marine Databasementioning

confidence: 99%

Database Compilation and Virtual Screening of Secondary Metabolites Derived From Marine Fungi as Epidermal Growth Factor Receptor Tyrosine Abstract Kinase Inhibitors

Watty

Syahdi

Yanuar

2017

Asian J Pharm Clin Res

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Objective: Epidermal growth factor receptor (EGFR), a transmembrane protein with cytoplasmic kinase activity, transduces growth factor signaling from the extracellular space to the cell. EGFR downstream signaling increases proliferation and reduces apoptosis. Agents that are targeted at intracellular tyrosine kinase are tyrosine kinase inhibitor small molecules, which have a mechanism of action that affects adenosine triphosphate binding to the receptor. The exploration of bioactive compounds from marine materials, including marine fungi, has become a major interest lately for anticancer treatment. Methods:In this research, a database was created and in silico screening was conducted using AutoDock and Vina to obtain potential marine fungi bioactive compounds as EGFR-tyrosine kinase (EGFR-TK) inhibitors, which act as antiproliferative agents on tumor cell growth. Results:This research has concluded that the three marine fungi compounds with the lowest binding free energy, FU0015, FU0051, and FU0202, have great potential as inhibitors of EGFR-TK.Keywords: Marine fungi compounds, Epidermal growth factor receptor-tyrosine kinase, Virtual screening, AutoDock, Vina, Antiproliferative. INTRODUCTIONEpidermal growth factor receptor (EGFR) is an important target in the process of reducing tumor growth. More than 60% of non-small cell lung cancers express EGFR [1]. EGFR downstream signaling increases proliferation and angiogenesis and reduces apoptosis [2]. The overexpression of EGFR has been detected in the majority of human carcinomas [3].Tyrosine kinase inhibitors (TKIs) are one of four classes of anti-EGFR agents used for cancer therapy [4]. In 2015, gefitinib (one of the TKIs) was approved by the Food and Drug Administration (FDA) as an inhibitor of EGFR [5]. In addition to synthetic drugs, natural products have an important role in cancer therapy. Chemical compounds from natural products can be potential new medicines. The exploration of bioactive compounds from marine materials, including marine fungi, has become a major activity lately for anticancer treatment. Currently, there are anticancer compounds from marine fungal metabolites that have entered clinical trials. One of the alkaloid compounds, plinabulin, is a modified structure based on the (-)-phenylahistin metabolites of the terrestrial and marine fungi Aspergillus ustus [6]. As the development of microbiology technology increases in the future, the availability of microorganisms such as marine fungi will increase and the costs of production will be reduced. Therefore, bioactive compounds of marine fungi have the potential to be new drug compounds [7]. A database of active compounds was created to ease in silico and in vitro research further.In silico research can support conventional research (wet lab) that is relatively expensive and takes time [8]. AutoDock (Automatic Docking) is widely used to predict the complex of a biomolecular structure or to perform functional analysis and molecular design. AutoDock uses a grid-based method to rapidly evalu...

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“…Since the discovery of spongothymidine and spongouridine in the early 50's [1], a large number of biologically active compounds were isolated from marine sponges and their associated microorganisms [2]. The chemical diversity of sponge-derived products is remarkable and their biological activity ranges from antiinflammatory, antitumour, immuno-or neurosuppressive, antiviral, antimalarial, antibiotic to antifouling [3].…”

Section: Introductionmentioning

confidence: 99%

Secondary Metabolites From Micromonospora Sp. (G044)

Tuan¹,

Hương²,

Ngan³

et al. 2017

JST

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In the course of our screening program, the EtOAc extract of a Micromonospora sp. (strain G044) from sponge Tethya aurantium of the sea of Côtô -Thanh Lân exhibited antimicrobial activity against Enterococcus faecalis, Bacillus cereus and Candida albicans. In this paper, we reported the isolation and structural elucidation of six secondary metabolites Cyclo-(Pro-Trp) (1), Cyclo-(Pro-Met) (2), Cyclo-(Pro-Val) (4), N-acetyltryptamine (3), uridine (5), and 2-phenylacetic acid (6) from the cultures broth of Micromonospora sp. (strain G044). The structures of 1 -6 were determined by analyses of MS and 2D NMR data. All compounds were evaluated for their antimicrobial activity against a panel of clinically significant microorganisms. Compound 1 inhibited Escherichia coli with a MIC value of 128 µg/ml.

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Bioactive Compounds from Marine Bacteria and Fungi

Cited by 319 publications

References 74 publications

Isomethoxyneihumicin, a new cytotoxic agent produced by marine Nocardiopsis alba KM6-1

Isomethoxyneihumicin, a new cytotoxic agent produced by marine Nocardiopsis alba KM6-1

Database Compilation and Virtual Screening of Secondary Metabolites Derived From Marine Fungi as Epidermal Growth Factor Receptor Tyrosine Abstract Kinase Inhibitors

Secondary Metabolites From Micromonospora Sp. (G044)

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