Bioactive compounds from Paecilomyces tenuipes regulating the function of the hypothalamo-hypophyseal system axis in chronic unpredictable stress rats

Yin, Yong; Ming, Liang; Zheng, Liqin; Kan, Hongwei; Li, Chunru; Li, Weiping

doi:10.1097/00029330-200706020-00011

Cited by 24 publications

(17 citation statements)

References 16 publications

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“…Dysregulation of the HPA axis system plays an important role in the pathophysiology of depression. [25,26] Normalization of axis hyperactivity precedes the response to pharmacotherapy. In the present study, CMS produced an increase in serum cortisol levels.…”

Section: Discussionmentioning

confidence: 99%

Possible mechanism of the antidepressant effect of 3,6′-disinapoyl sucrose from Polygala tenuifolia Willd

Liu

et al. 2011

Journal of Pharmacy and Pharmacology

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Section: Discussionmentioning

confidence: 99%

Possible mechanism of the antidepressant effect of 3,6′-disinapoyl sucrose from Polygala tenuifolia Willd

Liu

et al. 2011

Journal of Pharmacy and Pharmacology

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“…For example, MR mRNA within the whole hippocampus was reduced by CMS (Yin et al, 2007). Similarly, cytosolic MR binding within whole hippocampus is reduced by CMS (Kim et al, 1999).…”

Section: Neurochemical Systemsmentioning

confidence: 99%

Neurobiology of chronic mild stress: Parallels to major depression

Hill

Hellemans

Verma

et al. 2012

Neuroscience & Biobehavioral Reviews

369

223

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The chronic mild (or unpredictable/variable) stress (CMS) model was developed as an animal model of depression more than 20 years ago. The foundation of this model was that following long-term exposure to a series of mild, but unpredictable stressors, animals would develop a state of impaired reward salience that was akin to the anhedonia observed in major depressive disorder. In the time since its inception, this model has also been used for a variety of studies examining neurobiological variables that are associated with depression, despite the fact that this model has never been critically examined to validate that the neurobiological changes induced by CMS are parallel to those documented in depressive disorder. The aim of the current review is to summarize the current state of knowledge regarding the effects of chronic mild stress on neurobiological variables, such as neurochemistry, neurochemical receptor expression and functionality, neurotrophin expression and cellular plasticity. These findings are then compared to those of clinical research examining common variables in populations with depressive disorders to determine if the changes observed following chronic mild stress are in fact consistent with those observed in major depression. We conclude that the chronic mild stress paradigm: (1) evokes an array of neurobiological changes that mirror those seen in depressive disorders and (2) may be a suitable tool to investigate novel systems that could be disturbed in depression, and thus aid in the development of novel targets for the treatment of depression.

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“…In the present study, cortisol has been measured as an indicator of stress, yet corticosterone is the equivalent in the rat. Similarly, other studies have used cortisol as an index of stress in the rat [40][41][42]. A study by Gong et al [43] showed that rodent serum cortisol and corticosterone were closely correlated in patterns under different physiological or stressful conditions.…”

Section: Discussionmentioning

confidence: 99%

Effect of Maternal Water Restriction on Sexual Behavior, Reproductive Performance, and Reproductive Hormones of Male Rat Offspring

Al-Khaza’leh

Kridli

Obeidat

et al. 2020

Animals

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The present study aimed to investigate the effect of maternal water restriction on sexual behavior, reproductive performance, and reproductive hormones of male rat offspring. Forty pregnant female rats were divided into two equal groups: Control (C) and water-restricted (WR). Control dams had ad libitum water access throughout pregnancy, while dams in the WR group were subjected to 50% water-restriction from day 10 of pregnancy onwards. The maternal water restriction provoked a significant reduction (p < 0.05) in body weight of dams before delivery and at birth and litter body weights of offspring at birth. Maternal water restriction did not affect relative weights of reproductive and body organs of male rat offspring. All hormonal concentrations, sperm count, and vitality in male rat offspring were not significantly affected by maternal water restriction. Maternal water restriction exposure induced significant (p < 0.05) reduction in intromission latency, intromission frequency, and post-ejaculation interval in male rat offspring while a significant (p < 0.05) increase in the ejaculation latency was detected in maternal WR group. In conclusion, this study suggests that maternal water restriction had a negative impact on some reproductive characteristics but did not severely affect reproductive performance and reproductive hormones of male rat offspring.

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Bioactive compounds from Paecilomyces tenuipes regulating the function of the hypothalamo-hypophyseal system axis in chronic unpredictable stress rats

Cited by 24 publications

References 16 publications

Possible mechanism of the antidepressant effect of 3,6′-disinapoyl sucrose from Polygala tenuifolia Willd

Possible mechanism of the antidepressant effect of 3,6′-disinapoyl sucrose from Polygala tenuifolia Willd

Neurobiology of chronic mild stress: Parallels to major depression

Effect of Maternal Water Restriction on Sexual Behavior, Reproductive Performance, and Reproductive Hormones of Male Rat Offspring

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