Bioactive Compounds from Pale Ale Beer Powder Attenuate Experimental Colitis in BALB/c Mice

Abstract

Phenolic compounds (PCs) present in foods are associated with a decreased risk of developing inflammatory diseases. The aim of this study was to extract and characterize PCs from craft beer powder and evaluate their potential benefits in an experimental model of inflammatory bowel disease (IBD). PCs were extracted and quantified from pure beer samples. BALB/c mice received either the beer phenolic extract (BPE) or beer powder fortified with phenolic extract (BPFPE) of PCs daily for 20 days by gavage. Colon samples were collected for histopathological and immunohistochemical analyses. Dextran sodium sulfate (DSS)-induced mice lost more weight, had reduced colon length, and developed more inflammatory changes compared with DSS-induced mice treated with either BPE or BPFPE. In addition, in DSS-induced mice, the densities of CD4- and CD11b-positive cells, apoptotic rates, and activation of NF-κB and p-ERK1/2 MAPK intracellular signaling pathways were higher in those treated with BPE and BPFPE than in those not treated. Pretreatment with the phenolic extract and BPFPE remarkably attenuated DSS-induced colitis. The protective effect of PCs supports further investigation and development of therapies for human IBD.

Microencapsulated and Ready-to-Eat Beetroot Soup: A Stable and Attractive Formulation Enriched in Nitrate, Betalains and Minerals

“…No morphological differences were observed between beetroot soup microparticles prepared at different ratios in starch or maltodextrin. The polysaccharide agents, however, modified microparticle morphology, with starch microcapsules presenting a spherical and irregular geometry with few surface depressions and aggregation formed by the adhesion of smaller particles to the surface of larger ones, in contrast to the maltodextrin microparticles, which presented a vitreous appearance, as described elsewhere [ 47 , 48 , 49 ]. Furthermore, no cracks or open pores were observed in either type of microparticle.…”

Pretreatment with IPA ameliorates colitis in mice: Colon transcriptome and fecal 16S amplicon profiling

“…Inflammatory bowel disease (IBD) is common persistent incendiary infection, accompanied by a range of symptoms due to intestinal dysfunction, including diarrhea, rectal bleeding, abdominal pain and weight loss ( 1 , 2 ). The incidence of IBD has become a major health issue in recent years ( 3 , 4 ). Recent basic studies have identified risk factors for IBD that include malabsorption of selected nutrients ( 5 ) and the use of immunomodulators ( 6 ).…”