Bioactive compounds from Smilax excelsa L.

Khaligh, Pooneh; Salehi, Peyman; Farimani, Mahdi Moridi; Ali‐Asgari, Safa; Esmaeili, Mohammad Ali; Ebrahimi, Samad Nejad

doi:10.1007/s13738-016-0819-9

Cited by 16 publications

(13 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Compound 7 was characterized as kaempferol 3- O -α- l -rhamnoside, and this was supported by data from the literature [ 43 , 44 ]. Compound 8 was characterized as 3,5,4′-trihydroxy- trans -stilbene, by comparing the obtained spectroscopic data with previously published data [ 45 , 46 ]. Compound 9 was determined to be 2-feruloyl- O -α- d -glucopyranoyl-(1′→2)-3,6- O -feruloyl-β- d -fructofuranoside, by comparing these data with previous reports [ 47 , 48 , 49 ].…”

Section: Resultsmentioning

confidence: 99%

Chemical Constituents of Smilax china L. Stems and Their Inhibitory Activities against Glycation, Aldose Reductase, α-Glucosidase, and Lipase

2017

View full text Add to dashboard Cite

The search for natural inhibitors with anti-diabetes properties has gained increasing attention. Among four selected Smilacaceae family plants, Smilax china L. stems (SCS) showed significant in vitro anti-glycation and rat lens aldose reductase inhibitory activities. Bioactivity-guided isolation was performed with SCS and four solvent fractions were obtained, which in turn yielded 10 compounds, including one phenolic acid, three chlorogenic acids, four flavonoids, one stilbene, and one phenylpropanoid glycoside; their structures were elucidated using nuclear magnetic resonance and mass spectrometry. All solvent fractions, isolated compounds, and stem extracts from plants sourced from six different provinces of South Korea were next tested for their inhibitory effects against advanced glycation end products, as well as aldose reductase. α-Glucosidase, and lipase assays were also performed on the fractions and compounds. Since compounds 3, 4, 6, and 8 appeared to be the superior inhibitors among the tested compounds, a comparative study was performed via high-performance liquid chromatography with photodiode array detection using a self-developed analysis method to confirm the relationship between the quantity and bioactivity of the compounds in each extract. The findings of this study demonstrate the potent therapeutic efficacy of SCS and its potential use as a cost-effective natural alternative medicine against type 2 diabetes and its complications.

show abstract

Section: Resultsmentioning

confidence: 99%

Chemical Constituents of Smilax china L. Stems and Their Inhibitory Activities against Glycation, Aldose Reductase, α-Glucosidase, and Lipase

2017

View full text Add to dashboard Cite

show abstract

“…Based on the inhibition percentages, it was determined that S. excelsa fruit extracts exhibited strong antimutagenic activity. In literature, catechin [8], trans-resveratrol, 5-Ocaffeoylbicimic acid, 6-O-caffeoyl-β-Dfructofuranosyl-(2→1)-α-D glucopyranozide [17] and phytochemical compounds [18] are reported in Smilax tissues. And also in this study the presence of phenolic and flavonoid compounds in S. excelsa fruit extracts was determined.…”

Section: Discussionmentioning

confidence: 99%

“…Ozsoy et al [8] reported that S. excelsa leaf extracts have a total phenol content of 8.8-35.7 GAE mg g -1 and a flavonoid content of 0.61-28.7 mg g -1 catechin equivalent. Khaligh et al [17] reported the isolation of trans-resveratrol, 5-Ocaffeoylshikimic acid, 6-O-caffeoyl-β-Dfructofuranosyl-(2→1) -α-D glucopyranozide structures from S. excelsa tissues. And the antioxidant activity exhibited by the tissues was associated with these structures.…”

Section: Discussionmentioning

confidence: 99%

Antimutagenic and Multi-Biological Activities of Smilax excelsa L. Fruit Extract

Efe

Yalçın

Çavuşoğlu

2019

Cumhuriyet Science Journal

View full text Add to dashboard Cite

In this study, antimutagenic, antimicrobial and antioxidant activities of Smilax excelsa L. fruit extract were evaluated. The antimicrobial effect was investigated by disk diffusion method and the antimutagenic effect was investigated by Ames/Salmonella/microsom test. The antioxidant properties of S. excelsa fruit samples were determined by investigating the total phenolic, flavonoid contents and 1,1diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity. It was observed that 200 mg plate-1 fruit extract was found to have a mutagenicity inhibition as 81% in the absence of S9 mixture and 67% in the presence of S9 mixture against Salmonella typhimurium TA1535. S. excelsa fruit extract produced an inhibition zone in the range of 11-16 cm against the tested microorganisms. Flavonoid and phenolic contents were found to be 0.7985±0.0124 mgQE 100 mL-1 and 11.9847±0.0041 mgGAE 100 mL-1 at the 200 mg mL-1 extract concentration, respectively. The DPPH removal rate was determined to be 55% at the 200 mg L-1 dose. As a result, it was observed that the S. excelsa fruit tissues exhibited a highly antimutagenic activity and has been determined as a potential natural antimicrobial and antioxidant source.

show abstract

“…The extract with the highest content of total phenols was the infusion. The decoction and infusion showed major DPPH (Figure 11) [30]. The extraction was a maceration performed at room temperature.…”

Section: Smilax Domingensismentioning

confidence: 99%

“…In these study, also was evaluated the cytotoxicity of isolated compounds against human breast adenocarcinoma MCF-7cell lines. The 6-Ocaffeoylβ-D-fructofuranosyl-(2→1)αDglucopyranoside showed a promising activity against MCF-7 cell lines [30]. Phenolic Compounds -Natural Sources, Importance and Applications…”

Section: Smilax Domingensismentioning

confidence: 99%

Phenolic Compounds in Genus Smilax (Sarsaparilla)

Salas-Coronado¹,

Hernández-Carlos²,

Llaguno-GuilbertoJoseoziel³

et al. 2017

Phenolic Compounds - Natural Sources, Importance and Applications

View full text Add to dashboard Cite

Smilax (Smilacaceae) is a genus of about 350 species, found in temperate, tropical and subtropical zones worldwide. The plants belonging to this genus are found throughout Asia, Europe, Oceania and the Americas. Species of the genus Smilax commonly called sarsaparilla are characterized as climbers, with long, thin thorny stem. The branches have tendrils which attach to other plants or objects and grow steadily upward. The roots of these plants have been used for centuries in Asia and the Americas as a tonic, diuretic and sudorific. The rhizome, roots, stems and leaves of sarsaparilla are used in traditional medicine. In the scientific literature, there are several reports on immunomodulatory properties, anticonvulsant, antibacterial, antifungal, anticancer, antidiabetic and antioxidant properties. However, there are no reports which explain the antioxidant activity of sarsaparilla extracts as a function of phenolic compound structures, such as flavonoids and phenylpropanoids. In this chapter, the relevance of phenolic chemical structure in antioxidant and anticancer activity of sarsaparilla extracts will be described. Special emphasis is placed on phenylpropanoid glycosides that consist of a sucrose core. These compounds are evidence of chemotaxonomy in the genus Smilax.

show abstract

Bioactive compounds from Smilax excelsa L.

Cited by 16 publications

References 8 publications

Chemical Constituents of Smilax china L. Stems and Their Inhibitory Activities against Glycation, Aldose Reductase, α-Glucosidase, and Lipase

Chemical Constituents of Smilax china L. Stems and Their Inhibitory Activities against Glycation, Aldose Reductase, α-Glucosidase, and Lipase

Antimutagenic and Multi-Biological Activities of Smilax excelsa L. Fruit Extract

Phenolic Compounds in Genus Smilax (Sarsaparilla)

Contact Info

Product

Resources

About