Bioactive Compounds of Dietary Origin and Their Influence on Colorectal Cancer as Chemoprevention

Delgado-Gonzalez, Paulina; Garza-Treviño, Elsa N.; de la Garza Kalife, David A.; Quiroz Reyes, Adriana; Hernández-Tobías, Esther Alhelí

doi:10.3390/life13101977

Cited by 5 publications

(3 citation statements)

References 127 publications

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“…Cancer metastasis represents one of the most challenging aspects of cancer progression, often leading to poor prognostic outcomes [94] and bioactive compounds have emerged as potential agents in suppressing metastasis, acting through various cellular mechanisms to inhibit the spread and colonization of cancer cells in distant organs. [95] β-carbolines have exhibited antimetastatic effects by inhibiting processes involved in cancer cell migration, invasion, and metastasis (Miao et al, 2021;Ding et al, 2019). They can reduce the activity of proteins associated with metastasis, such as matrix metalloproteinases (MMPs), and interfere with signaling pathways involved in cell motility and epithelial-mesenchymal transition (EMT).…”

Section: Metastasis Suppressionmentioning

confidence: 99%

Anticancer Potential of β‐Carboline Alkaloids: An Updated Mechanistic Overview

Tshikhudo,

Mabhaudhi,

Koorbanally

et al. 2024

Chemistry & Biodiversity

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This comprehensive review is designed to evaluate the anticancer properties of β‐carbolines derived from medicinal plants, with the ultimate goal of assessing their suitability and potential in cancer treatment, management, and prevention. An exhaustive literature survey was conducted on a wide array of β‐carbolines including, but not limited to, harmaline, harmine, harmicine, harman, harmol, harmalol, pinoline, tetrahydroharmine, tryptoline, cordysinin C, cordysinin D, norharmane, and perlolyrine. Various analytical techniques were employed to identify and screen these compounds, followed by a detailed analysis of their anticancer mechanisms. Natural β‐carbolines such as harmaline and harmine have shown promising inhibitory effects on the growth of cancer cells, as evidenced by multiple in vitro and in vivo studies. Synthetically derived β‐carbolines also displayed noteworthy anticancer, neuroprotective, and cognitive‐enhancing effects. The current body of research emphasizes the potential of β‐carbolines as a unique source of bioactive compounds for cancer treatment. The diverse range of β‐carbolines derived from medicinal plants can offer valuable insights into the development of new therapeutic strategies for cancer management and prevention.

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Section: Metastasis Suppressionmentioning

confidence: 99%

Anticancer Potential of β‐Carboline Alkaloids: An Updated Mechanistic Overview

Tshikhudo,

Mabhaudhi,

Koorbanally

et al. 2024

Chemistry & Biodiversity

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“…There have been investigations of effective phytochemicals inhibiting cancer signaling pathways. Consequently, the scientific and medical communities are very interested in the bioactivities of natural phytochemicals and their potential to prevent cancer [24,25]. A wide range of potential chemopreventive bioactives is being studied.…”

Section: Terpenoid-mediated Cancer Chemopreventionmentioning

confidence: 99%

Terpenoid-Mediated Targeting of STAT3 Signaling in Cancer: An Overview of Preclinical Studies

Khan,

Pandey,

Verma

et al. 2024

Biomolecules

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Cancer has become one of the most multifaceted and widespread illnesses affecting human health, causing substantial mortality at an alarming rate. After cardiovascular problems, the condition has a high occurrence rate and ranks second in terms of mortality. The development of new drugs has been facilitated by increased research and a deeper understanding of the mechanisms behind the emergence and advancement of the disease. Numerous preclinical and clinical studies have repeatedly demonstrated the protective effects of natural terpenoids against a range of malignancies. Numerous potential bioactive terpenoids have been investigated in natural sources for their chemopreventive and chemoprotective properties. In practically all body cells, the signaling molecule referred to as signal transducer and activator of transcription 3 (STAT3) is widely expressed. Numerous studies have demonstrated that STAT3 regulates its downstream target genes, including Bcl-2, Bcl-xL, cyclin D1, c-Myc, and survivin, to promote the growth of cells, differentiation, cell cycle progression, angiogenesis, and immune suppression in addition to chemotherapy resistance. Researchers viewed STAT3 as a primary target for cancer therapy because of its crucial involvement in cancer formation. This therapy primarily focuses on directly and indirectly preventing the expression of STAT3 in tumor cells. By explicitly targeting STAT3 in both in vitro and in vivo settings, it has been possible to explain the protective effect of terpenoids against malignant cells. In this study, we provide a complete overview of STAT3 signal transduction processes, the involvement of STAT3 in carcinogenesis, and mechanisms related to STAT3 persistent activation. The article also thoroughly summarizes the inhibition of STAT3 signaling by certain terpenoid phytochemicals, which have demonstrated strong efficacy in several preclinical cancer models.

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“…The use of nutritional/dietary supplements (e.g., calcium, vitamin D, folate, phytochemicals, n-3 PUFAs, etc.) or pharmacologically active compounds (re-purposed drugs-e.g., aspirin) are ranked among the most applied CRC prevention strategies [2,8,9].…”

Section: Introductionmentioning

confidence: 99%

Genistein–Aspirin Combination Exerts Cytotoxic and Anti-Migratory Effects in Human Colorectal Cancer Cells

Iftode,

Iurciuc,

Marcovici

et al. 2024

Life

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Colorectal cancer (CRC) is a heterogenous pathology with high incidence and mortality rates globally, but it is also preventable so finding the most promising candidates (natural compounds or repurposed drugs) to be chemopreventive alternatives has become a topic of interest in recent years. The present work aims to elucidate the potential effects of a combination between genistein (GEN), an isoflavone of natural origin, and aspirin (ASA) in CRC prevention/treatment by performing an in vitro evaluation in human colorectal cancer cells (HCT-116) and an in ovo analysis using the chick embryo chorioallantoic membrane (CAM) model. Cell viability was verified by an MTT (migratory potential by scratch) assay, and the expressions of MMP-2 and MMP-9 were analyzed using RT-qPCR. Our results indicated a dose-dependent cytotoxic effect of ASA (2.5 mM) + GEN (10–75 µM) combination characterized by reduced cell viability and morphological changes (actin skeleton reorganization and nuclei deterioration), an inhibition of HCT-116 cells’ migratory potential by down-regulating MMP-2 and MMP-9 mRNA expressions, and an antiangiogenic effect by modifying the vascular network. These promising results raise the possibility of future in-depth investigations regarding the chemopreventive/therapeutical potential of ASA+GEN combination.

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Bioactive Compounds of Dietary Origin and Their Influence on Colorectal Cancer as Chemoprevention

Cited by 5 publications

References 127 publications

Anticancer Potential of β‐Carboline Alkaloids: An Updated Mechanistic Overview

Anticancer Potential of β‐Carboline Alkaloids: An Updated Mechanistic Overview

Terpenoid-Mediated Targeting of STAT3 Signaling in Cancer: An Overview of Preclinical Studies

Genistein–Aspirin Combination Exerts Cytotoxic and Anti-Migratory Effects in Human Colorectal Cancer Cells

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