Bioactive Compounds of Marking Nut (Semecarpus anacardium Linn.)

Gore, Mohini; Jagtap, Umesh B.

doi:10.1007/978-3-030-06120-3_23-1

Cited by 3 publications

(2 citation statements)

References 33 publications

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“…Ethanolic extract of SA (100 mg/kg) reduced blood glucose level in normoglycemic rats. However, no effect was observed in case of hyperglycemic rats [49,50].…”

Section: Hypoglycemic Effectmentioning

confidence: 88%

Impact of Shodhana on Semecarpus anacardium Nuts

Sahu¹,

Tiwari²

2021

Alternative Medicine - Update

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Semecarpus anacardium is classified in Ayurveda under the category of toxic plants. However, this toxic plant is reported to possess anti-inflammatory activity, anti-arthritic effect, antioxidant activity, antimicrobial activity, anti- carcinogenic activity, hypoglycemic activity, cardioprotective, hepatoprotective, neuroprotective, and hypolipidemic activity etc. All these activities are attributed to its various constituents like phenolic compounds, flavonoids, carbohydrates, alkaloids, steroids, etc. In Ayurveda, a series of pharmaceutical procedures which converts a poisonous drug into a safe and therapeutically effective medicine is termed as Shodhana. Shodhana improves the yield, decreases the phenolic and flavonoid content; and converts toxic urushiol into nontoxic anacardol derivative thereby reducing toxicity of nuts of Semecarpus anacardium. There are reports of alteration in pharmacology and phytochemistry of nuts of Semecarpus anacardium due to Shodhana.

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“…Ethanolic extract of SA (100 mg/kg) reduced blood glucose level in normoglycemic rats. However, no effect was observed in case of hyperglycemic rats [49,50].…”

Section: Hypoglycemic Effectmentioning

confidence: 88%

Impact of Shodhana on Semecarpus anacardium Nuts

Sahu¹,

Tiwari²

2021

Alternative Medicine - Update

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“…The corresponding short names for these tripeptides are FAR, FAY, FVY, FWC, and FWY. In a similar way, the p K a values for each of the tripeptides will be calculated by resorting to a methodology previously considered by us, 16 and the descriptors of bioactivity (bioactivity scores) will be established through a procedure described in the literature, 17,18 trying to relate them with the global and local CDFT reactivity descriptors that result from a calculation protocol based on DFT already validated by our group in previous research. 19−26…”

Section: Introductionmentioning

confidence: 99%

Computational Peptidology Assisted by Conceptual Density Functional Theory for the Study of Five New Antifungal Tripeptides

Flores-Holgúın

Frau

2019

ACS Omega

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A well-behaved model chemistry previously validated for the study of the chemical reactivity of peptides was considered for the calculation of the molecular properties and structures of a group of five new antifungal tripeptides, namely (2 R )-2-[(2 S )-2-[(2 S )-2-amino-3-phenylpropanamido]propanamido]-5-[(diaminomethylidene)amino]pentanoic acid, (2 S )-2-[(2 S )-2-[(2 S )-2-amino-3-phenyl propanamido]propanamido]-3-(4-hydroxyphenyl)propanoic acid, (2 S )-2-[(2 S )-2-[(2 S )-2-amino-3-phenylpropanamido]-3-methylbutanamido]-3-(4-hydroxyphenyl)propanoic acid, (2 R )-2-[(2 S )-2-[(2 S )-2-amino-3-phenylpropanamido]-3-(1 H -indol-3-yl)propanamido]-3-sulfanylpropanoic acid, and (2 S )-2-[(2 S )-2-[(2 S )-2-amino-3-phenylpropanamido]-3-(1 H -indol-3-yl)propanamido]-3-(4-hydroxyphenyl)propanoic acid, according to their amino acid sequences. A methodology based on conceptual density functional theory was chosen for the determination of the reactivity descriptors. The molecular active sites were associated with the active regions of the molecules that were associated with the nucleophilic, electrophilic, and radical Fukui functions. Additionally, the p K a values for the different peptides are predicted with great accuracy, which constitutes a useful knowledge for the process of drug design. Finally, the bioactivity scores for the new antifungal peptides are predicted through a homology methodology relating them with the calculated reactivity descriptors.

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Acute Toxicity Study of Hexane Extract of <i>Sodhita Semecarpus anacardium</i> L. Drupe in Wistar Albino Rats and its Prediction Using <i>In-Silico</i> Tool

Gopinath,

Arunadevi

2024

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Semecarpus anacardium L. belongs to the family Anacardiaceae. Its drupe is widely used in Ayurvedic formulations after sodhana processing as it is listed under Schedule E1 of the Drugs and Cosmetics Act 1940. In this study, sodhita Semecarpus anacardium L. drupe was extracted with n-hexane and the yield was found to be 56%. The extract was subjected to GCMS (Gas Chromatography Mass Spectrometry) analysis and its characteristics were studied using an in silico tool. Acute oral and dermal toxicity studies were performed on the Wistar albino rats as per the OECD 425 and 402 guidelines respectively. The GCMS data revealed the presence of C13H18O3 (m/z: 222.1) with an abundance of 93.63%. The compound was predicted as potentially hazardous with a probable mutagenic category of ICH M7 class 3. An oxirane functional group of the compound was predicted to cause potent irritation properties to the eyes and skin with positive scores of 0.76 and 0.57 respectively. The LD50 was found to be more than the limit dose of 2000mg/kg body weight upon oral administration. Acute dermal exposure at a limited dose of 2000mg/kg body weight did not cause mortality. However, inflammatory responses started appearing within 48 hours of exposure. Histopathology revealed mild dermal oedema, mild fibrosis, dilated follicles hyperplasia etc. No changes were found in haematological parameters. Inflammation and dermal allergic reactions were completely self-healed by the end of 14 days. The results suggest that the oil portion of the sodhita drupe possesses the irritant properties of the Semecarpus anacardium. It might be due to the presence of the compound C13H18O3 with Oxirane as a functional group.

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Bioactive Compounds of Marking Nut (Semecarpus anacardium Linn.)

Cited by 3 publications

References 33 publications

Impact of Shodhana on Semecarpus anacardium Nuts

Impact of Shodhana on Semecarpus anacardium Nuts

Computational Peptidology Assisted by Conceptual Density Functional Theory for the Study of Five New Antifungal Tripeptides

Acute Toxicity Study of Hexane Extract of <i>Sodhita Semecarpus anacardium</i> L. Drupe in Wistar Albino Rats and its Prediction Using <i>In-Silico</i> Tool

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