Bioactive Compounds of Porcine Hearts and Aortas May Improve Cardiovascular Disorders in Humans

Чернуха, И. М.; Kotenkova, Elena; Дербенева, С.А.; Khvostov, Daniil

doi:10.3390/ijerph18147330

Cited by 11 publications

(12 citation statements)

References 64 publications

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“…Sensory and physicochemical parameters of the canned meat "Healthy Heart" must meet the following requirements (Table 2). Porcine aorta and heart are used as the main raw materials as they contain 1) tissue-specific peptides with molecular weights of 809.4 ± 1.0; 776.5 ± 1.0; 765.6 ± 1.0; 739.2 ± 1.0; 710.8 ± 1.0; 229.2 ± 1.0; 162.1 ± 1.0; 156.0 ± 1.0; 148.1 ± 1.0; 140.2 ± 1.0 and 133.1 ± 1.0 kDa; 2) Apo 1 (contributes to the formation of high-density lipoproteins) or 3) pre-Apo A-1 (participates in the inhibition of oxidative stress) [58][59][60].…”

Section: Resultsmentioning

confidence: 99%

Systemic approach in the development of functional foods for various noncommunicable diseases

Чернуха

Nikitina

Aslanova

et al. 2022

Teor. prakt. pererab. mâsa (Print)

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The article presents a hierarchy of requirements necessary for the successful design of food products with given composition and properties considering age restrictions and various diseases. The need for generalization and systematization of scientifically based principles, specific medical and biological requirements for food products, diets for the most common nutritional diseases in the knowledge base is shown. Using the k-means cluster analysis method, 1) meat raw materials were analyzed for inclusion in functional food for gerodietetic nutrition according to the most significant descriptors (protein, methionine + cystine amino acids, tryptophan), 2) spicy herbs and spices were analyzed for inclusion in the Muhammara recipe as natural antioxidant sources according to the descriptor of antioxidant properties. Using the example of the Muhammara recipe change, all stages of a systemic approach in the development of functional foods are shown. The first stage is related to obtaining information from the knowledge base about scientifically based nutritional principles and specific biomedical requirements for the given age group. At the second stage, the clustering of raw materials of animal and vegetable origin is carried out in order to reasonably include in the recipe of food product being developed. At the third stage, a system of balance linear algebraic equations for the chemical composition of the food product being developed (mass fraction of fat, protein, water, carbohydrates, vitamins, macro- and microelements, amino acids, etc.) is formed. The fourth stage is associated with the establishment of the target function (optimization criterion), and restrictions for recipe and balance. At the fifth stage, the problem is solved using a high-level language in a modern programming environment. At the final (sixth) stage, the nutritional value of the optimal balanced recipe is analyzed considering the target function and the given restrictions. As a result, we receive a modified Muhammara recipe with optimized protein: fat ratio. Mathematical simulation was carried out using the R Studio software with open-source lpSolve and lpSolveAPI libraries.

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Section: Resultsmentioning

confidence: 99%

Systemic approach in the development of functional foods for various noncommunicable diseases

Чернуха

Nikitina

Aslanova

et al. 2022

Teor. prakt. pererab. mâsa (Print)

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“…Total antioxidant activity was determined by the rate of the oxidation of the reduced form of 2,6-dichlorophenolindophenol (DCPIP) in the reaction medium using a spectrophotometer (HTI, HTI, Farmington, MI, USA) [ 65 ]. The de Ritis coefficient was calculated as the ratio of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activity according to the following formula [ 66 ]:

…”

Section: Methodsmentioning

confidence: 99%

The Hypoglycemic and Hypocholesterolemic Activity of Dioscorea deltoidea, Tribulus terrestris and Panax japonicus Cell Culture Biomass in Rats with High-Fat Diet-Induced Obesity

et al. 2023

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Obesity, and its consequences for human health, is a huge and complicated problem that has no simple solution. The constant search for natural and safe compounds with systemic action that can be used for obesity prophylactics and treatment is hampered by the limited availability and variable quality of biomass of wild medicinal plants. Plant cell biotechnology is an alternative approach for the sustainable production of vegetative biomass or individual phytochemicals with high therapeutic potential. In this study, the suspension cell biomass of the medicinal plants, Dioscorea deltoidea Wall., Tribulus terrestris L., and Panax japonicus (T. Nees) C.A. Mey, produced in 20 L and 630 L bioreactors, were tested for therapeutic effects in rat models with alimentary-induced obesity. Three-month intake of water infusions of dry cell biomass (100 mg/g body weight) against the background of a hypercaloric diet reduced weight gain and the proportion of fat mass in the obese animals. In addition, cell biomass preparation reduced the intracellular dehydration and balanced the amounts of intra- and extracellular fluids in the body as determined by bioimpedance spectroscopy. A significant decrease in the glucose and cholesterol levels in the blood was also observed as a result of cell biomass administration for all species. Hypocholesterolemic activity reduced in the line P. japonicus > D. deltoidea > T. terrestris/liraglutide > intact group > control group. By the sum of parameters tested, the cell culture of D. deltoidea was considered the most effective in mitigating diet-induced obesity, with positive effects sometimes exceeding those of the reference drug liraglutide. A safety assessment of D. deltoidea cell phytopreparation showed no toxic effect on the reproductive function of the animals and their offspring. These results support the potential application of the biotechnologically produced cell biomass of medicinal plant species as safe and effective natural remedies for the treatment of obesity and related complications, particularly for the long-term treatment and during pregnancy and lactation periods when conventional treatment is often contraindicated.

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“…Chromatographic separation of the studied polyphenol compounds was performed using an UHPLC 1290 Infinity system (Agilent Technologies, Santa Clara, CA, USA) [ 16 ]. Separation was achieved using a ZORBAX RRHD Eclipse Plus C18 analytical column (2.1 mm × 100 mm, 1.8 μm particle size, Agilent Technologies, Santa Clara, CA, USA).…”

Section: Methodsmentioning

confidence: 99%

Differences in Antioxidant Potential of Allium cepa Husk of Red, Yellow, and White Varieties

et al. 2022

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The effective management of agro-industry organic waste for developing high-commercial-value products is a promising facet of the circular economy. Annually, more than 550,000 tons of waste that is potentially rich in biologically active substances is generated worldwide while processing onions (Allium cepa L.). The antioxidant potential of red, yellow, and white onion husks was studied using FRAP, ORAC, chemiluminescence, and UPLC-ESI-Q-TOF-MS analysis methods. The extraction of phenolic compounds from onion husks was more effective when using an aqueous solution of 70% ethanol as compared with water. Ethanolic extract from red onion husks exhibited the highest TACORAC and TACFRAP values, averaging 2017.34 µmol-equiv. Trolox/g raw material and 2050.23 µmol-equiv. DQ/g raw material, respectively, while the white onion exhibited much lower levels of antioxidants. According to the chemiluminescence results, it was determined that the red and yellow onion husks contained antioxidants of three types of power, while white onion husks only contained medium and weak types. The highest content of flavonoids was found in red onion husks, averaging 1915.90 ± 9.92 µg-eq. DQ/g of raw material and 321.42 ± 2.61 µg-eq. DQ/g of raw material for ethanol and water, respectively, while yellow onion husks exhibited 544.06 ± 2.73 µg-eq. DQ/g of raw material and 89.41 ± 2.08 for ethanol and water, respectively. Quercetin and its glycosides were the most representative flavonoids, and a number of substances with different pharmacological and biological properties were also identified.

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Bioactive Compounds of Porcine Hearts and Aortas May Improve Cardiovascular Disorders in Humans

Cited by 11 publications

References 64 publications

Systemic approach in the development of functional foods for various noncommunicable diseases

Systemic approach in the development of functional foods for various noncommunicable diseases

The Hypoglycemic and Hypocholesterolemic Activity of Dioscorea deltoidea, Tribulus terrestris and Panax japonicus Cell Culture Biomass in Rats with High-Fat Diet-Induced Obesity

Differences in Antioxidant Potential of Allium cepa Husk of Red, Yellow, and White Varieties

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