Bioactive Compounds of the Wonder Medicinal Mushroom “Ganoderma lucidum”

Sudheer, Surya; Alzorqi, Ibrahim; Manickam, Sivakumar; Ali, Asgar

doi:10.1007/978-3-319-54528-8_45-1

Cited by 7 publications

(20 citation statements)

References 110 publications

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“…A mixture of G. lucidum polysaccharides (known as GLP) is the main bioactive component in water-soluble extracts of the mushroom, and there is some evidence that GLP possesses potential anticancer activity (Sohretoglu & Huang, 2018). These metabolites influence the patient's innate and adaptive immune system, resulting in therapeutic immune modification (Berovič & Podgornik, 2015;Wang et al, 2017;Sudheer et al, 2018). Other metabolites found in extracts of Ganoderma have been found to be stimulators of neural stem cell proliferation in vitro and could be valuable treatments for neurodegenerative diseases (Yan et al, 2015).…”

Section: Relevance To Commercially Cultivated Fungimentioning

confidence: 99%

A 21st century miniguide to sporophore morphogenesis and development in Agaricomycetes and their biotechnological potential

Loftus¹,

Sánchez²,

Moore³

et al. 2020

Mexjbiotechnol

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We review the most recent developments in understanding the nature of development and morphogenesis in fungi and suggest how it might be applied to biotechnological manipulation of some cultivated mushrooms. We believe that it is essential to match the deductions of the molecular observations of the genomics generation with the inductive reasoning of the in vivo experiments and observations of the pregenomics generations to take full advantage of the synergism between the approaches to illuminate better the living biology of the system. As specific examples we show how model mushroom fungi (Coprinopsis and Volvariella) make hymenia and gills (not forgetting how the polypore Phellinus makes tubes), developmental commitment and pattern formation. The Coprinopsis sporophore also provides examples for the construction of mushroom stems and the coordination of cell behaviour throughout the maturing sporophore and the timing process that achieves that. This leads us to consider the mechanics of the mushroom and its dependence on the biochemistry and regulation of metabolism in relation to morphogenesis, and how it varies between species. We finish with our summary of the basic principles of fungal developmental biology. Having demonstrated how classic approaches allowed progress to be made in the study of fungal development we show how this has been accelerated by genomics and other aspects of global analysis of macromolecules. We also include work on some cultivated mushrooms to illustrate how the generalisations from research on model organisms might be applied in mushroom farming.

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Section: Relevance To Commercially Cultivated Fungimentioning

confidence: 99%

A 21st century miniguide to sporophore morphogenesis and development in Agaricomycetes and their biotechnological potential

Loftus¹,

Sánchez²,

Moore³

et al. 2020

Mexjbiotechnol

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“…It is commonly named "Lingzhi" in Chiana and "Reishi" in Japan [11]. Ganoderma is one of the most common medicinal mushrooms used traditionally for the longevity and promotion of human health [12] [13] [14]. It is considered a popular folk medicine for the treatment of general disorders, arthritis, hepatitis, bronchitis, dermatological disorders and to boost up the immune functions by indigenous peoples worldwide [15].…”

Section: Introductionmentioning

confidence: 99%

Free Radical Scavenging, Enzyme Inhibitory and Anti-<i>Staphylococcus aureus</i> Properties of the Fruiting Bodies of <i>Ganoderma lucidum</i>, Lingzhi Mushroom

Pk¹,

Islam²,

Haque³

et al. 2021

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The current study evaluated the antioxidant, α-amylase inhibitory and anti-Staphylococcus aureus activities of the fruiting bodies of Ganoderma lucidum. Methanolic extract of G. lucidum (MEGL) was investigated for its in vitro antioxidant activity using 1,1-diphenyl 2-picrylhydrazyl (DPPH) assay and EC 50 value was determined. α-Amylase inhibitory and anti-S. aureus activities were carried out by conventional methods. The mushroom extract showed maximum free radical scavenging activity at a dose of 500 µg/mL with EC 50 value of 22.1399 µg/mL. EC 50 value for the inhibition of α-amylase activity was found 22.6011 µg/mL. G. lucidum extracts exhibited a concentration-dependent Anti-S. aureus activity. The vast differences of this inhibition between lower and higher doses were assessed significantly (p < 0.05). This study shows that the fruiting body of G. lucidum has moderate antioxidant, α-amylase inhibitory, and anti-S. aureus activities. Thus this mushroom may be the alternative plant source for the antioxidant, anti-diabetic and antibacterial agents and further in vivo studies and isolation of bioactive compounds are required.

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“…Karst., also known as Ling Zhi, Reishi, Mannentake is a medicinal, wooddegrading basidiomycete with numerous pharmacological effects in addition to its key role in the environment as decomposer in nutrient cycle. G. lucidum is considered as "the king of herbs" which grows on the decaying and dead logs of deciduous trees like willow, oak, sweet gum, maple, elm and coniferous trees (larix, picea and pinus) (Khatian and Aslam, 2018;Sudheer et al, 2018). The most important pharmacologically active constituents of G. lucidum are triterpenoids and polysaccharides.…”

Section: Introductionmentioning

confidence: 99%

“…lucidum is not classified as edible mushroom and not used in cooking because of its bitter taste and a wooden texture, however it is used in other various forms (Hapuarachchi et al, 2016a). In terms of ethnomedicinal knowledge, it has been widely used to promote health and longevity in Traditional Chinese Medicine as special teas or concoctions in China, Japan, and other Asian countries for over two millennia (Sudheer et al, 2018). It was both considered as the "herb of spiritual potency" or "plant of immortality" that extended the lifetime because of its medicinal properties by Chinese people and symbolized sanctity, success, goodness, happiness, fortune, immortality, and good health in these countries (Paterson, 2006;Sanodiya et al, 2009;Wachtel-Galor et al, 2011;De Silva et al, 2012;Hapuarachchi et al, 2018;Sudheer et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

“…In terms of ethnomedicinal knowledge, it has been widely used to promote health and longevity in Traditional Chinese Medicine as special teas or concoctions in China, Japan, and other Asian countries for over two millennia (Sudheer et al, 2018). It was both considered as the "herb of spiritual potency" or "plant of immortality" that extended the lifetime because of its medicinal properties by Chinese people and symbolized sanctity, success, goodness, happiness, fortune, immortality, and good health in these countries (Paterson, 2006;Sanodiya et al, 2009;Wachtel-Galor et al, 2011;De Silva et al, 2012;Hapuarachchi et al, 2018;Sudheer et al, 2018). It was first indexed in Shen Nong's Materia Medica (206 BC-8 AD), known as the "Father of Chinese medicine", as a longevity promoting and tonic herb of the non-toxic superior class (Zhu et al, 2007;Sharma et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

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Health Benefits of Ganoderma lucidum as a Medicinal Mushroom

Bulam

Üstün

Pekşen

2019

Turkish JAF Sci.Tech.

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Ganoderma lucidum (Curtis) P. Karst., known as “Lingzhi” in China or “Reishi” in Japan, is a well-known medicinal mushroom and traditional Chinese medicine, which has been used for the prevention and treatment of bronchitis, allergies, hepatitis, immunological disorders and cancer. G. lucidum is rarely collected from nature and mostly cultivated on wood logs and sawdust in plastic bags or bottles to meet the demands of international markets. Diverse groups of chemical compounds with pharmacological activities, isolated from the mycelia and fruiting bodies of G. lucidum are triterpenoids, polysaccharides (β-D-glucans), proteins, amino acids, nucleosides, alkaloids, steroids, lactones, lectins, fatty acids, and enzymes. The biologically active compounds as primarily triterpenoids and polysaccharides of G. lucidum have been reported to possess hepatoprotective, antihypertensive, hypocholesterolemic, antihistaminic effects and antioxidant, antitumor, immunomodulatory, and antiangiogenic activities. Several formulations have been developed, patented and used as nutraceuticals, nutriceuticals and pharmaceuticals from G. lucidum’s water or ethanol extracts and rarely purified active compounds. As the result of clinical trials, various products have commercially become available as syrup, injection, tablet, tincture or bolus of powdered medicine and an ingredient or additive in dark chocolate bars and organic fermented medicinal mushroom drink mixes such as green teas, coffees, and hot cacaos. This review has intended to give and discuss recent knowledge on phytochemical and pharmacological compositions, therapeutic and side effects, clinical trials, and commercial products of G. lucidum.

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Bioactive Compounds of the Wonder Medicinal Mushroom “Ganoderma lucidum”

Cited by 7 publications

References 110 publications

A 21st century miniguide to sporophore morphogenesis and development in Agaricomycetes and their biotechnological potential

A 21st century miniguide to sporophore morphogenesis and development in Agaricomycetes and their biotechnological potential

Free Radical Scavenging, Enzyme Inhibitory and Anti-<i>Staphylococcus aureus</i> Properties of the Fruiting Bodies of <i>Ganoderma lucidum</i>, Lingzhi Mushroom

Health Benefits of Ganoderma lucidum as a Medicinal Mushroom

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Bioactive Compounds of the Wonder Medicinal Mushroom “Ganoderma lucidum”

Cited by 7 publications

References 110 publications

A 21st century miniguide to sporophore morphogenesis and development in Agaricomycetes and their biotechnological potential

A 21st century miniguide to sporophore morphogenesis and development in Agaricomycetes and their biotechnological potential

Free Radical Scavenging, Enzyme Inhibitory and Anti-&lt;i&gt;Staphylococcus aureus&lt;/i&gt; Properties of the Fruiting Bodies of &lt;i&gt;Ganoderma lucidum&lt;/i&gt;, Lingzhi Mushroom

Health Benefits of Ganoderma lucidum as a Medicinal Mushroom

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Product

Resources

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Free Radical Scavenging, Enzyme Inhibitory and Anti-<i>Staphylococcus aureus</i> Properties of the Fruiting Bodies of <i>Ganoderma lucidum</i>, Lingzhi Mushroom