Bioactive constituents from Flacourtia vogelii Hook.f. (Flacourtiaceae)

Abstract

The chemical investigation of the methanolic root extract of Flacourtia vogelii led to the isolation of a new arylbenzoate derivative, vogelinal (1), together with thirteen known compounds (2 -14). The structures of the isolates were elucidated by extensive spectroscopic and spectrometric analyses (1D and 2D NMR, ESI-MS) and by comparison with previously reported data. All the compounds were tested for their antioxidant, antifungal and antibacterial activities. Compound 7 exhibited the highest antioxidant potential, with RSa50 of 11.80 ± 2.13 µg/mL, RSa50 of 42.60 ± 6.32 µg/mL and RC50 of 51.60 ± 7.71 µg/mL for the DPPH, ABTS and FRAP assay, respectively. Compound 13 displayed weak antifungal effect with MIC value of 125 μg/mL against Candida parapsilosis. Compound 8 showed weak antibacterial effect with MIC value of 125 μg/mL, against Shigella dysenteria. The present study, conclude that this species could be a promising source of antioxidant and antibacterial constituents.

Influence of particle size fraction and bioactive compound contents on the biological activities of Solanum torvum L. leaf powder extracts

“…Consequently, the obtained polyphenol contents are adequate. However, the observed weak antibacterial activities can be attributed to the lipophilic nature of all the isolates, which hinders their entry into the hydrophilic periplasmic space of bacterial strains of isolates (Dongmo et al 2023). These results affirm that S. torvum leaves are a valuable source of bioactive compounds used in traditional medicine for treating infectious diseases (Loganayaki et al 2010;Senizza et al 2021;Rajapaksha and Premathilake 2020;Jan et al 2024).…”

“…Flavonoids, an essential group of natural polyphenolic compounds characterized by their flavan core, are primarily found in vegetables, fruits, and plant-based beverages. Due to their multiple biological activities, including antimicrobial, antioxidant, antidiabetic, and anticancer properties (Maizuwo 2017;Dongmo et al 2023;Murugesan et al 2024), these are an indispensable component in the field of health.…”