Bioactive constituents from the green alga Caulerpa racemosa

Yang, Peng; Liu, Dingquan; Liang, Tong-Jun; Li, Jia; Zhang, Haiyan; Liu, Aihong; Guo, Yue‐Wei; Mao, Shui-Chun

doi:10.1016/j.bmc.2014.11.031

Cited by 72 publications

(39 citation statements)

References 42 publications

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“…503 This is a structural class rarely found in the Chlorophyta. Also reported were diterpenoids, 731-733, an a-tocopheroid 734, a sterol 735 along with 12 known compounds from Caulerpa racemosa 504 and a triterpene acid 736 from Codium dwarkense. 505 The diterpenoid 733 and the a-tocopheroid 734 are the rst natural products to contain the haematinic acid and 3,5dimethylphenoxy motifs respectively.…”

Section: Green Algaementioning

confidence: 99%

Marine natural products

et al. 2017

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Covering: 2015. Previous review: Nat. Prod. Rep., 2016, 33, 382-431This review covers the literature published in 2015 for marine natural products (MNPs), with 1220 citations (792 for the period January to December 2015) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1340 in 429 papers for 2015), together with the relevant biological activities, source organisms and country of origin. Reviews, biosynthetic studies, first syntheses, and syntheses that lead to the revision of structures or stereochemistries, have been included.

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Section: Green Algaementioning

confidence: 99%

Marine natural products

et al. 2017

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“…From C. racemosa , fucosterol and the oxygenated sterols 7 – 10 in Figure 3 were isolated, together with both C-24 epimers of saringosterol 2 [30,31]. …”

Section: Structural Characterization and Biological Activitymentioning

confidence: 99%

“…From C. racemosa , several varied metabolites were obtained by Yang et al [31]. These include trans -phytol, trans -phytylacetate, α-tocopherolquinone, and the metabolites 11 – 17 in Figure 4.…”

Section: Structural Characterization and Biological Activitymentioning

confidence: 99%

“…In addition, the cytotoxic activities of the isolated compounds were tested against the human cancer cell lines A-549 (human lung carcinoma) and HL-60 (promyelocytic leukemia cells). Only the mixture of 11 and 12 , 16 , and α-tocopherolquinone exhibited moderate cytotoxicity against HL-60, and α-tocopherolquinone exhibited weak cytotoxicity against A-549 [31]. …”

Section: Structural Characterization and Biological Activitymentioning

confidence: 99%

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Secondary Metabolites and Biological Activity of Invasive Macroalgae of Southern Europe

et al. 2018

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In this review a brief description of the invasive phenomena associated with algae and its consequences on the ecosystem are presented. Three examples of invasive algae of Southern Europe, belonging to Rodophyta, Chlorophyta, and Phaeophyta, were selected, and a brief description of each genus is presented. A full description of their secondary metabolites and biological activity is given and a summary of the biological activity of extracts is also included. In Asparagopsis we encounter mainly halogenated compounds. From Caulerpa, several terpenoids and alkaloids were isolated, while in Sargassum, meroterpenoids prevail.

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“…, anticancer (Moussavou et al, 2014), antihypertensive (Seca & Pinto, 2018), antidiabetic, and anti-HIV activities (Thomas & Kim, 2011). Previous reports have also revealed the neuroprotective effects of some seaweeds such as Ecklonia cava (Alghazwi et al, 2016), Ecklonia bicyclis (Jung, Oh, & Choi, 2010) Caulerpa racemose (Yang et al, 2015), and Ecklonia kurome (Hu et al, 2004) against some neurodegenerative diseases.…”

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confidence: 98%

Aqueous–ethanol extracts of some South African seaweeds inhibit beta‐amyloid aggregation, cholinesterases, and beta‐secretase activities in vitro

2019

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In this study, we evaluated the anti‐amyloidogenic, anticholinesterase, and antioxidant potentials of hydroethanolic extracts of Ecklonia maxima (ECK), Gelidium pristoides (GLD), Gracilaria gracilis (GCL), and Ulva lactuca (ULT). The effect of the extracts on β‐amyloid (Aβ1‐42) peptide were determined using electron microscope. The effects of the extracts on β‐secretase and cholinesterase activities, as well as their radical scavenging and metal chelating activities were also assessed. Electron micrographs revealed that ECK, GLD, GCL, and ULT incubated with Aβ1‐42 at different intervals (0–96 hr) showed very low levels of fibrils compared to the control. The extracts also inhibited β‐secretase, acetylcholinesterase, and butyrylcholinesterase activities in a dose‐dependent manner. Furthermore, the extracts scavenged hydroxyl radicals and were able to chelate Fe2+ in a dose‐dependent manner. Our findings suggest that the seaweed extracts are potential sources of lead compounds and novel inhibitors of β‐amyloid aggregation, β‐secretase, and cholinesterases for the management of Alzheimer's diseases. Practical applications Seaweeds have been identified as good sources of naturally occurring bioactive compounds with several medicinal properties. They are commonly used as functional foods and development of nutraceuticals, dietary supplements, and cosmeceuticals. However, the neuroprotective effects of many species of seaweeds have not been fully explored. The findings of this study suggests that Gracilaria gracilis, Ulva lactuca, Ecklonia maxima, and Gelidium pristoides are potential sources of cholinesterase, beta‐secretase, and amyloid protein aggregation inhibitors. Hence, this support the use of these seaweeds as alternative sources of antioxidants and natural compounds with neuroprotective potentials for the management of Alzheimer's disease.

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Bioactive constituents from the green alga Caulerpa racemosa

Cited by 72 publications

References 42 publications

Marine natural products

Marine natural products

Secondary Metabolites and Biological Activity of Invasive Macroalgae of Southern Europe

Aqueous–ethanol extracts of some South African seaweeds inhibit beta‐amyloid aggregation, cholinesterases, and beta‐secretase activities in vitro

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