Bioactive constituents from the rhizomes of Dioscorea septemloba Thunb

Bioactive Constituents from the Aerial Parts of Pluchea indica Less

“…Extract, eluent and compounds obtained from the aerial parts of P. indica were used to pretreat the cells for 1 h before stimulating with LPS (500 ng/mL) for 24 h. After incubation, each culture medium (50 µL) was mixed with an equal volume of Griess reagent. An ELISA plate reader was used to determine the nitrite levels at 540 nm, and the concentrations were calculated by referring to a NaNO 2 standard calibration curve [ 38 ].…”

Bioactive Constituents from the Roots of Eurycoma longifolia

“…The planar structure was clarified by the long-range correlations observed from the followling proton to carbon pairs: δ H 3.69 (3-OCH 3 ), 6.56 (H-5) to δ C 148.4 (C-3); δ H 6.48 (H-6), 6.57 (H-2) to δ C 145.4 (C-4); δ H 2.73, 2.96 (H 2 -7) to δ C 113.8 (C-2), 122.6 (C-6), 133.2 (C-1), 139.0 (C-5’); δ H 3.97 (H-8) to δ C 119.4 (C-6’), 133.2 (C-1), 139.0 (C-5’), 145.2 (C-4’); δ H 6.92 (H-6’), 6.95 (H-2’) to δ C 145.2 (C-4’); δ H 3.83 (3’-OCH 3 ), 6.95 (H-2’) to δ C 153.5 (C-3’); δ H 6.65 (H-7’) to δ C 109.2 (C-2’), 119.4 (C-6’), 135.2 (C-1’); δ H 4.68 (H-1’’) to δ C 145.2 (C-4’); δ H 4.37 (H-1’’’) to δ C 70.8 (C-9’) (Figure 4). The chemical shift value of C-8 (δ C 42.9, in CD 3 OD) suggested the absolute configuration of it might be 8 R [26]. Finally, it was clarified by its cotton effect [mdeg −23.1 (259 nm)] displayed in circular dichroism (CD) spectrum [27].…”

“…Moreover, the existence of d -glucose was elucidated by the HCl hydrolysis result [24]. The absolute configuration of C-8 was determined as R by using the same method [26,27] as those for compound 3 , and the structure of 4 was elucidated and named as eurylolignanoside B.…”

Spirostane-Type Saponins Obtained from Yucca schidigera

“…As one of the secondary metabolites, spirostanol saponins have been found to have broad bioactivities, such as antiproliferative, anti-inflammatory [ 1 , 2 , 3 , 4 ], anti-HIV [ 5 ], anti-bacterial [ 6 ], anti-fungi [ 7 ], and anti-hyperuricemic [ 8 ] activities, which make the phytochemical or bioactive researches for spirostanol saponins meaningful.…”

“…In our on-going program of investigating spirostanol saponins [ 3 , 4 , 8 ] from natural products, we found that Yucca schidigera Roezl (Agavaceae family) is a plant rich in these kinds of constituents. As one of the major industrial sources of steroid saponins, Y. schidigera is native to the desert of the southwestern United States and northern Baja California, Mexico [ 9 ].…”