Bioactive constituents isolated from the Sri Lankan endemic plant Artocarpus nobilis and their potential to use in novel cosmeceuticals

Liyanaarachchi, Gavini Dilkhushi; Perera, Anton Sameera; Samarasekera, Jayanetti Koralalage Ramani Radhika; Mahanama, K.R.R.; Hemalal, Kirihettiliyanage Don Patrick; Dlamini, Samkeliso; Perera, Hettiarachchige Dona Sachindra Melshandi; Alhadidi, Qasim; Shah, Zahoor A.; Tillekeratne, L. M. V.

doi:10.1016/j.indcrop.2022.115076

Cited by 3 publications

(1 citation statement)

References 49 publications

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“…We found a minor ameliorating effect in the humans treated with TROSYD (Group 3) compared with those treated with PSOE (Group 2), which might have been due to the concentrations of the chemicals in the pharmacological creams. As minor side effects are generally observed with pharmacological treatments, the use of natural cosmetic constituents from plants has become a target for studies [ 17 , 45 , 46 , 47 ].…”

Section: Discussionmentioning

confidence: 99%

Biochemical Pilot Study on Effects of Pomegranate Seed Oil Extract and Cosmetic Cream on Neurologically Mediated Skin Inflammation in Animals and Humans: A Comparative Observational Study

Hamouda

Felemban

2023

Molecules

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The presence of phenobarbital and formaldehyde in drugs, food, and beverages can lead to various health issues, including inflammation, oncogenesis, and neurological distress. Psychological stress leads to mood fluctuations and the onset of skin inflammation. Skin inflammation has a range of causes, including chemicals, heavy metals, infection, immune-related disorders, genetics, and stress. The various treatments for skin inflammation include medical and cosmetic creams, diet changes, and herbal therapy. In this study, we investigated the effects of Avocom-M and pomegranate seed oil extract (PSOE) against phenobarbital- and formaldehyde-induced skin biochemical changes in rats. We analyzed the constituents of PSOE using gas chromatography–mass spectrometry and inductively coupled plasma–mass spectrometry. We also observed biochemical changes in the skin of human volunteers with and without TROSYD and PSOE as a skin cream. We compared the biochemical changes in human volunteers’ skin before treatment and 21 days after the treatment stopped. The outcomes showed an improvement in the rats’ biochemical status, due to PSOE and Avocom-M treatment. The human volunteers treated with TROSYD and PSOE showed substantial amelioration of skin inflammation. PSOE, Avocom-M, and TROSYD produced beneficial effects by reducing the levels of cyclooxygenase-2, lipid peroxidation, tyrosinase, hyaluronidase, elastase, collagenase, and nitric oxide in the animals tested on and in human volunteers.

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Section: Discussionmentioning

confidence: 99%

Biochemical Pilot Study on Effects of Pomegranate Seed Oil Extract and Cosmetic Cream on Neurologically Mediated Skin Inflammation in Animals and Humans: A Comparative Observational Study

Hamouda

Felemban

2023

Molecules

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Formulation and evaluation of a hydrogel containing a bioactive extract of Murraya koenigii for topical applications

Perera,

Samarasekera,

Handunnetti

et al. 2023

Journal of Herbal Medicine

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Chemical composition’s effect on Solanum nigrum Linn.’s antioxidant capacity and erythrocyte protection: Bioactive components and molecular docking analysis

Aouadi,

Saoud,

Rebiai

et al. 2024

Open Life Sciences

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Oxidative stress has been widely believed to be the mechanism responsible for developing diseases such as arthritis, asthma, dementia, and aging.Solanum nigrumLinn. is a common edible medicinal herb that belongs to the family Solanaceae which has more than 180 chemical components that have so far been discovered. The main bioactive components of these are steroidal saponins, alkaloids, phenols, and polysaccharides. This article presents comparative phytochemical profiling including total phenolic, total flavonoid, alkaloid, proanthocyanidins, tannin, and vitamin C contents of three AlgerianS. nigrumsamples collected from three different locations in the Algerian desert. Additionally, the potential antioxidant activity of the three samples was assessed by 2,2-diphenyl-1-picrylhydrazyl, ferric reducing antioxidant power, and oxidative hemolysis inhibition assay. Moreover, the correlation between the major phenolic phytoconstituents previously reported and isolated from the plant and antioxidant activity has also been done byin silicomolecular docking. Ten bioactive compounds were docked with selected proteins, arachidonate-5-lipoxygenase (PDB: 6n2w) and cytochromecperoxidase (PDB: 2x08), to check their affinity with binding sites of these proteins for the possible mechanism of action. The docking scores suggest thatS. nigrum’s quercetin and kaempferol may play a significant role in its antioxidant action.

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Bioactive constituents isolated from the Sri Lankan endemic plant Artocarpus nobilis and their potential to use in novel cosmeceuticals

Cited by 3 publications

References 49 publications

Biochemical Pilot Study on Effects of Pomegranate Seed Oil Extract and Cosmetic Cream on Neurologically Mediated Skin Inflammation in Animals and Humans: A Comparative Observational Study

Biochemical Pilot Study on Effects of Pomegranate Seed Oil Extract and Cosmetic Cream on Neurologically Mediated Skin Inflammation in Animals and Humans: A Comparative Observational Study

Formulation and evaluation of a hydrogel containing a bioactive extract of Murraya koenigii for topical applications

Chemical composition’s effect on Solanum nigrum Linn.’s antioxidant capacity and erythrocyte protection: Bioactive components and molecular docking analysis

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