Bioactive Constituents of F. esculentum Bee Pollen and Quantitative Analysis of Samples Collected from Seven Areas by HPLC

Li, Feng; Guo, Sheng; Zhang, Shanshan; Peng, Sainan; Cao, Wei; Ho, Chi Tang; Bai, Naisheng

doi:10.3390/molecules24152705

Cited by 22 publications

(28 citation statements)

References 49 publications

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“…Tyrosinase is an enzyme involved in the biosynthesis of melanin in humans, and its inhibitors are of interest for preventing excessive melanin production, as being active ingredients of skin whitening agents. Tyrosinase inhibitory activity (IC 50 : 202.37 μg/mL) of EP was also detected by Bai et al [ 160 ].…”

Section: Endoperoxidesmentioning

confidence: 62%

Structure and Biological Activity of Ergostane-Type Steroids from Fungi

2022

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Mushrooms are known not only for their taste but also for beneficial effects on health attributed to plethora of constituents. All mushrooms belong to the kingdom of fungi, which also includes yeasts and molds. Each year, hundreds of new metabolites of the main fungal sterol, ergosterol, are isolated from fungal sources. As a rule, further testing is carried out for their biological effects, and many of the isolated compounds exhibit one or another activity. This study aims to review recent literature (mainly over the past 10 years, selected older works are discussed for consistency purposes) on the structures and bioactivities of fungal metabolites of ergosterol. The review is not exhaustive in its coverage of structures found in fungi. Rather, it focuses solely on discussing compounds that have shown some biological activity with potential pharmacological utility.

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Section: Endoperoxidesmentioning

confidence: 62%

Structure and Biological Activity of Ergostane-Type Steroids from Fungi

2022

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“…Bee pollen of safflower is a mixture of the pollen and nectar of safflower and bee gland secretions, which not only supplies nutrition to bees and larvae but is also popular as a nutritional product (Kocot et al, 2018). Polysaccharides are the most abundant components of bee pollen, accounting for 18.9-57.6% of the dried powder (Li et al, 2019). In recent years, an increasing number of studies have shown that PBPC possess a variety of biological effects, such as antioxidant, immunomodulatory, antitumor, anticoagulant and antibacterial activities (Li et al, 2017c;Zuo et al, 2017;Wang et al, 2019b;Chen et al, 2019;Wang et al, 2019c;Shi et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Extraction, Structures, Bioactivities and Structure-Function Analysis of the Polysaccharides From Safflower (Carthamus tinctorius L.)

Cai

et al. 2021

Front. Pharmacol.

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Safflower (Carthamus tinctorius L.) is a herbal plant with a long history of clinical application worldwide, such as coronary heart disease, hypertension, dysmenorrhea and amenorrhea. It is also extensively used as an important oilseed plant for hundreds of years in some countries, like China, India, Mexico and the United States. Therefore, safflower is believed as a crop with dual values of medicine and economy as well. Safflower polysaccharides (SPS), from the plant, are believed as one of the most important biologically active components with multiple pharmacological properties, including anti-tumor, immune regulation, anti-oxidation, and anti-cerebral ischemia reperfusion injury effects. The polysaccharides, from bee pollen of safflower, named PBPC, also attract the attention of researchers because of their particular origin and bioactivities. Although the extraction, purification, structure and biological activities of SPS and PBPC have been studied for decades, there is not any available review both concerning SPS and PBPC. In this condition, this paper aims to systematically review the research progress in extraction, purification, structural characteristics, and bioactivities of SPS and PBPC, and provide basis for the in-depth study about their structure-bioactivity relationship. It will serve as a methodological outline for further research in fields of new drug discovery and clinical application of SPS or PBPC, and simultaneously remind us of unresolved problems noted in the polysaccharide research.

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“…Like other bee products, the bioactivities of bee pollen depended mainly on the plant origin and its geographical region (Arruda et al, 2013). In addition, the reported activity following fractionation is influenced by the extraction methods, extraction solvents, extraction numbers and extraction times (Li et al, 2019), as well as the assay conditions.…”

Section: Introductionmentioning

confidence: 99%

Safflospermidines from the bee pollen of Helianthus annuus L. exhibit a higher in vitro antityrosinase activity than kojic acid

Khongkarat

Ramadhan

Phuwapraisirisan

et al. 2020

Heliyon

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Background: Ozone deterioration in the atmosphere has become a severe problem causing overexposure of ultraviolet light, which results in humans in melanin overproduction and can lead to many diseases, such as skin cancer and melasma, as well as undesirable esthetic appearances, such as freckles and hyperpigmentation. Although many compounds inhibit melanin overproduction, some of them are cytotoxic, unstable, and can cause skin irritation. Thus, searching for new natural compounds with antityrosinase activity and less/no side effects is still required. Here, bee pollen derived from sunflower (Helianthus annuus L.) was evaluated. Materials and methods: Sunflower bee pollen (SBP) was collected from Apis mellifera bees in Lopburi province, Thailand in 2017, extracted by methanol and sequentially partitioned with hexane and dichloromethane (DCM). The in vitro antityrosinase activity was evaluated using mushroom tyrosinase and the half maximal inhibitory concentration (IC 50 ) is reported. The antioxidation activity was determined using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay and reported as the half maximal effective concentration. Two pure compounds with antityrosinase activity were isolated by silica gel 60 column chromatography (SG 60 CC) and high performance liquid chromatography (HPLC), and their chemical structure deduced by Nuclear Magnetic Resonance (NMR) analysis. Results:The DCM partitioned extract of SBP (DCMSBP) had an antityrosinase activity (IC 50 , 159.4 μg/mL) and was fractionated by SG 60 CC, providing five fractions (DCMSBP1-5). The DCMSBP5 fraction was the most active (IC 50 ¼ 18.8 μg/mL) and further fractionation by HPLC gave two active fractions, revealed by NMR analysis to be safflospermidine A and B. Interestingly, both safflospermidine A and B had a higher antityrosinase activity (IC 50 of 13.8 and 31.8 μM, respectively) than kojic acid (IC 50 of 44.0 μM). However, fraction DCMSBP5 had no significant antioxidation activity, while fractions DCMSBP1-4 showed a lower antioxidation activity than ascorbic acid. Conclusion: Safflospermidine A and B are potential natural tyrosinase inhibitors.

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Bioactive Constituents of F. esculentum Bee Pollen and Quantitative Analysis of Samples Collected from Seven Areas by HPLC

Cited by 22 publications

References 49 publications

Structure and Biological Activity of Ergostane-Type Steroids from Fungi

Structure and Biological Activity of Ergostane-Type Steroids from Fungi

Extraction, Structures, Bioactivities and Structure-Function Analysis of the Polysaccharides From Safflower (Carthamus tinctorius L.)

Safflospermidines from the bee pollen of Helianthus annuus L. exhibit a higher in vitro antityrosinase activity than kojic acid

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