Bioactive Constituents of the Leaves of <i>Phyllanthus polyphyllus</i> var. <i>siamensis</i>

Youkwan, Juthamanee; Srisomphot, Panida; Sutthivaiyakit, Somyote

doi:10.1021/np050001a

Cited by 19 publications

(10 citation statements)

References 25 publications

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“…Of which Phyllanthus oligospermus a shrub, is one of the most common species found in Taiwan. 1) Members of Phyllanthus have been reported to produce terpenes, 2,3) alkaloids, 4,5) lignans, [6][7][8] flavonoids, 9,10) and tannins 11,12) with diverse biological activities including inhibition of hepatitis B virus, hypoglycemic, hypotensive and diuretic effects and antinociceptive, antitumor, antioxidant, and antiinflammatory properties. Many species of this genus have long been used in the traditional Chinese medicine for the treatment of eye disease, jaundice, headache, eczema, warts, diarrhea, diabetes, hepatitis and dropsy for liver protection and as diuretic.…”

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confidence: 99%

Cytotoxic Arylnaphthalene Lignans from Phyllanthus oligospermus

2006

Chem. Pharm. Bull.

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Three new arylnaphthalene lignans, namely phyllanthusmins A-C, together with nine known compounds were isolated and characterized from the stems and roots of Phyllanthus oligospermus by a bioassay-guided purification. The structures of the new compounds were elucidated by means of spectroscopic data interpretation. Among them, phyllanthusminA displayed significant cytotoxicity against KB and P-388 cancer cell lines.

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confidence: 99%

Cytotoxic Arylnaphthalene Lignans from Phyllanthus oligospermus

2006

Chem. Pharm. Bull.

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“…[19] The genus Phyllanthus contains highly valued medicinal plants which produce a variety of secondary metabolites including flavonoids, phenolic acids, alkaloids, lignans, and tannins, have long been extensively used in folk medicine all over the world. [20] P. polyphyllus has been investigated for their various bioactive properties such as anti-inflammatory, [18] anti-tumour, [21] cytotoxic, [21,22] and hepatoprotective activities. [23,24] Species of these plant genera are used in folk medicine and consumed as healthy ingredients, they could also be useful in preventing mould growth and mycotoxin contamination due to their antifungal properties.…”

Section: Introductionmentioning

confidence: 99%

Evaluation ofPhyllanthus polyphyllusL. Extract and its Active Constituent as a Source of Antifungal, Anti-Aflatoxigenic, and Antioxidant Activities

Abhishek

Mohana

Thippeswamy

et al. 2014

International Journal of Food Properties

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The present investigation was carried out to evaluate the antifungal activities of Phyllanthus polyphyllus L. leaf extract, to isolate its active constituent 4-o-methyl gallic acid (4-o-MGA), and to determine the antioxidant and antiaflatoxigenic properties. The bioassay-guided fractionation of methanol extract led to the isolation of active compound 4-o-methylgallic acid. The methanol extract showed the highest amount of phenolic content (290 mg GAE/g dry extract), which indicated the involvement of phenolic compounds in the radical scavenging activity observed by the methanol extract. The antioxidant capacity of 4-o-MGA was greater than the standard butylated hydroxytoluene, followed by methanol extract. The concentration-dependent growth inhibitory activity was observed against the tested fungi, in which the field fungi were susceptible, while the storage fungi were found to be more resistant including aflatoxigenic A. flavus. A correlation was observed between fungal biomass and aflatoxin production in control and treatment, there was a decrease in biomass of A. flavus and aflatoxin production with increasing concentration. The aflatoxin production was completely inhibited in vitro by methanol extract at 1 mg/mL and 4-o-MGA at 2 mg/mL, but the mycelial growth was not inhibited completely. The inhibition of aflatoxin production was relatively higher than the mycelial growth inhibition of A. flavus, such behaviors might have been determined by the presence of hydrolysable tannin 4-o-MGA in the extract, which is known to inhibit the aflatoxin biosynthesis. The significant antioxidant and aflatoxin inhibitory activities of P. polyphyllus could be exploited for its application in preventing oxidative deterioration and fungal spoilage of food products.

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“…The phytochemical studies of the plant have revealed the presence of benzenoid, 4-0-methyl galic acid, together with three arylnapthalide lignans, namely phyllamyricin, justicidin B and diphyllin. Its extract shows dose-dependent inhibition of inflammatory mediators such as LPS/INF-Y stimulated by peritoneal exuded macrophages (Rao et al, 2006), monoacetylated triterpene arabinosides and terpenes found have cytotoxic activity against human cancer cell lines (Youkwan et al, 2005), antitumor activity against transplantable tumour, protective effect of human umbilical vein endothelial cells against glycated protein-iron chelate induced toxicity (Rajkapoor et al, 2007a(Rajkapoor et al, , 2007b. The present study is aimed to evaluate the protective role of methanol extract of P. polyphyllus against N-nitrosodiethylamine-induced liver tumor in rats.…”

Section: Introductionmentioning

confidence: 99%