Bioactive Dammarane-Type Saponins from <i>Operculina turpethum</i>

Ding, Wenbing; Zeng, Fanli; Xu, Liangxiong; Chen, Yunyun; Wang, Yifei; Wei, Xiaoyi

doi:10.1021/np200274m

Cited by 18 publications

(9 citation statements)

References 18 publications

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“…Dammarane-type saponins have shown potent hepatoprotective effects in different models [33–35], and these effects could justify the use of this plant for the treatment of liver disorders and malaria infection. …”

Section: Resultsmentioning

confidence: 99%

Immunobiologic and Antiinflammatory Properties of a Bark Extract fromAmpelozizyphus amazonicusDucke

Pecanha

Fernandes

Simen

et al. 2013

BioMed Research International

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Ampelozizyphus amazonicus is used in the treatment and prevention of malaria. The effect of an aqueous extract from this plant (SART) on the immune response was investigated by measuring immunoglobulin production induced by immunization with the antigen TNP-Ficoll in Plasmodium chabaudi-infected mice. SART treatment increased antigen-specific IgM and IgG levels in TNP-Ficoll-immunized mice. The B cell response during malarial infection was also modified by SART. There was an increase in total serum IgM and IgG and a decrease in the percentage of splenic plasma cells (CD138+ cells) in P. chabaudi-infected, SART-treated animals. SART (1, 3 or 10 mg/kg, p.o.) and the reference drug dexamethasone (5 mg/kg) were also tested in carrageenan-induced leukocyte migration to the subcutaneous air pouch (SAP). All SART doses significantly reduced leukocyte migration into the SAP. The protein concentration resulting from extravasation into the peritoneum was also significantly reduced. Our data indicate that SART possesses immunomodulatory properties, inducing an in vivo modification of the B lymphocyte response and anti-inflammatory properties, which are partly due to a reduction in cell migration and are most likely due to an inhibition of the production of inflammatory mediators. Preliminary HPLC-ESI-MS/MS analysis of SART shows a complex saponin profile with deprotonated molecule [M-H]− ions in the range of m/z 800–1000.

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Section: Resultsmentioning

confidence: 99%

Immunobiologic and Antiinflammatory Properties of a Bark Extract fromAmpelozizyphus amazonicusDucke

Pecanha

Fernandes

Simen

et al. 2013

BioMed Research International

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“…Some triterpenoids such as cycloartenol [ Figure 4 ], lanosta-5-ene [ Figure 5 ], and 24-methylene-δ-5-lanosterol and turpethosides were also isolated from the roots of OT. [ 32 33 34 ] Therapeutically, terpenoids are reported to exhibit antiviral, antibacterial, antitumor, antiseptic, diuretic, and analgesic activities. [ 35 ]…”

Section: Phytochemical Profilementioning

confidence: 99%

“…The absolute configuration of operculinoside A (1) was confirmed by X-ray crystallographic technique [ Figure 11 ]. [ 33 ] The chemical parameters of four new dammarane-type saponins, operculinosides A–D (1–4) are presented in Table 2 .…”

Section: Phytochemical Profilementioning

confidence: 99%

Operculina turpethum (Linn.) Silva Manso as a medicinal plant species: A review on bioactive components and pharmacological properties

Gupta¹,

Ved²

2017

Phcog Rev

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Operculina turpethum (Linn.) (OT) Silva Manso belongs to the family Convolvulaceae. This review incorporates literature for the phytochemical and pharmacological profile of OT herb. Exhaustive literature survey was done using all the details on phytochemistry and pharmacology of OT available. This herb was found to be a potent source of bioactive compounds such as α- and β-turpethein, turpethinic acids (A, B, C, D, and E), coumarins, cycloartenol, lanosta-5-ene, 24-methylene-δ-5-lanosterol, α- and β-rhamnose, β-sitosterol, lupeol, scopoletin, betulin, acrylamide, stigma-5,22dien-3-O-β-D-glucopyranoside, β-sitosterol-β-D-glucoside (H-1), 22,23-dihydro-α-spinosterol-β-D-glucoside (H-2), and salicylic acid (CH-2), which are useful in fevers, edema, ascites, anorexia, constipation, hepatosplenomegaly, hemorrhoids, cervical lymphadenitis, fistulas, constipation, chronic gout, fever, bronchitis, ulcers, hemorrhoids, tumors, obesity, jaundice, herpes, induce lacrimation, and other skin disorders. From the aerial parts of OT, four new dammarane-type saponins that are operculinosides A–D (1–4) were isolated that showed particular hepatoprotective activities. All the compounds are reported to possess pharmacological properties such as antibacterial, anti-inflammatory, analgesic, hepatoprotective, anti-arthritic, ulcer protective, antidiarrheal, antidiabetic, and cytotoxic properties.

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“…In order to complete and enrich the resource investigation of DTT, we summarize the literatures (1965–2016) describing this type of triterpenoids, extracted from various botanicals. In Table 1, 136 species, from Araliaceae, Cucurbitaceae, Rhamnaceae, and Meliaceae families, together with 42 others are summarized [4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,…”

Section: Plant Resources Of Dttmentioning

confidence: 99%

Plant Resources, 13C-NMR Spectral Characteristic and Pharmacological Activities of Dammarane-Type Triterpenoids

Ruan¹,

Zheng

Lu³

et al. 2016

Molecules

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Dammarane-type triterpenoids (DTT) widely distribute in various medicinal plants. They have generated a great amount of interest in the field of new drug research and development. Generally, DTT are the main bioactive ingredients abundant in Araliaceae plants, such as Panax ginseng, P. japonicas, P. notoginseng, and P. quinquefolium. Aside from Araliaceae, DTT also distribute in other families, including Betulaceae, Cucurbitaceae, Meliaceae, Rhamnaceae, and Scrophulariaceae. Until now, about 136 species belonging to 46 families have been reported to contain DTT. In this article, the genus classifications of plant sources of the botanicals that contain DTT are reviewed, with particular focus on the NMR spectral features and pharmacological activities based on literature reports, which may be benefit for the development of new drugs or food additives.

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Bioactive Dammarane-Type Saponins from Operculina turpethum

Cited by 18 publications

References 18 publications

Immunobiologic and Antiinflammatory Properties of a Bark Extract fromAmpelozizyphus amazonicusDucke

Immunobiologic and Antiinflammatory Properties of a Bark Extract fromAmpelozizyphus amazonicusDucke

Operculina turpethum (Linn.) Silva Manso as a medicinal plant species: A review on bioactive components and pharmacological properties

Plant Resources, 13C-NMR Spectral Characteristic and Pharmacological Activities of Dammarane-Type Triterpenoids

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