Bioactive dietary components—Anti‐obesity effects related to energy metabolism and inflammation

Bertoncini-Silva, Caroline; Zingg, Jean‐Marc; Fassini, Priscila Giácomo; Suen, Vívian Marques Miguel

doi:10.1002/biof.1921

Cited by 18 publications

(13 citation statements)

References 293 publications

(626 reference statements)

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“…We recommended shifting away from partially hydrogenated forms of coconut oil (a popular functional fat used in commercial products) and replacing these with extra-virgin, unrefined bioactive vegetable oils such as olive oil. We also provided options for fortification and recommendations to add specific nutrients, e.g., fatty acids and vitamins that are supportive of metabolic and brain health and function ( 98 , 99 ).…”

Section: Discussionmentioning

confidence: 99%

The Metabolic Matrix: Re-engineering ultraprocessed foods to feed the gut, protect the liver, and support the brain

Harlan

Gow

Kornstädt³

et al. 2023

Front. Nutr.

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Ultraprocessed food is established as a metabolic disruptor acting to increase adiposity, reduce mitochondrial efficiency, drive insulin resistance, alter growth, and contribute to human morbidity and mortality. Consumer packaged goods (CPG) companies are beginning to understand the detrimental impact of the food they market, and have employed substitution strategies to reduce salt, sugar, and fat. However, the harms of ultraprocessed foods are far more complex than any single component, and are not ameliorated by such simple substitutions. Over the past 2 years, the authors have worked with the Kuwaiti Danish Dairy Company (KDD) to conduct a comprehensive scientific evaluation of their entire commercial food and beverage portfolio. Assay of the macronutrients, micronutrients, additives, and toxins contained in each of their products was undertaken to determine the precise nature of each product’s ingredients as well as the health impacts of processing. The authors formed a Scientific Advisory Team (SAT) and developed a tiered “Metabolic Matrix” founded in three science-based principles: (1) protect the liver, (2) feed the gut, and (3) support the brain. The Metabolic Matrix categorizes each product and provides the criteria, metrics, and recommendations for improvement or reformulation. Real-time consultation with the KDD Executive and Operations teams was vital to see these procedures through to fruition. This scientific exercise has enabled KDD to lay the groundwork for improving the health, well-being, and sustainability of their entire product line, while maintaining flavor, economic, and fiscal viability. This process is easily transferrable, and we are sharing this effort and its approaches as a proof-of-concept. The key aim of our work is to not only make ultraprocessed food healthier but to urge other food companies to implement similar analysis and reformulation of their product lines to improve the metabolic health and well-being of consumers worldwide.

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Section: Discussionmentioning

confidence: 99%

The Metabolic Matrix: Re-engineering ultraprocessed foods to feed the gut, protect the liver, and support the brain

Harlan

Gow

Kornstädt³

et al. 2023

Front. Nutr.

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“…Evidence suggested that long-term low grade inflammatory basis led to obesity and associated co-morbidities [ 99 , 100 ]. However, low and high dosage administration of vitamin A decrease TNF- α and IL6 on obese adults [ 101 ]; therefore, reducing insulin resistance, and improving energy expenditure [ 102 ].…”

Section: Clinical Perspectivesmentioning

confidence: 99%

Vitamin A: A Key Inhibitor of Adipocyte Differentiation

Malibary

2023

PPAR Research

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Inhibiting adipocyte differentiation, the conversion of preadipocytes to mature functional adipocytes, might represent a new approach to treating obesity and related metabolic disorders. Peroxisome proliferator-activated receptor γ and CCAAT-enhancer-binding protein α are two master coregulators controlling adipogenesis both in culture and in vivo. Many recent studies have confirmed the relationship between retinoic acid (RA) and the conversion of embryonic stem cells into adipocytes; however, these studies have shown that RA potently blocks the differentiation of preadipocytes into mature adipocytes. Nevertheless, the functional role of RA in early tissue development and stem cell differentiation, including in adipose tissue, remains unclear. This study highlights transcription factors that block adipocyte differentiation and maintain preadipocyte status, focusing on those controlled by RA. However, some of these novel adipogenesis inhibitors have not been validated in vivo, and their mechanisms of action require further clarification.

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“…Studies have shown that obese people have a higher basal metabolic volume, which may be because obese people have a larger base weight and need more energy to support their base [49,50]. Banquets or parties attended for business or personal reasons, usually held in the evening, are often attended by people who drink alcohol and consume ultra-processed foods.…”

Section: Multilevel Logistic Regression Analysismentioning

confidence: 99%

The prevalence and modifiable lifestyle factors of central obesity among white-collar workers of different genders: A cross-sectional study

Xiaoqian,

Li,

et al. 2023

Preprint

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Background: Central obesity is strongly associated with obesity-related and metabolic diseases, which is a common health problem in sedentary adults, particularly in women, but the mechanisms remain unclear. This study aimed to investigate the prevalence and factors associated with central obesity in white-collar workers Chinese population, and explore potential sex differences. Methods: A cross-sectional study was conducted between 2017 and 2019 at two large general hospitals in northern and southern China. Totally 6,081 white-collar workers underwent a physical examination and completed an online health self-report questionnaire, which included demographic variables, lifestyle factors and blood lipid test. Multilevel logistic regression analysis was performed to assess the prevalence and factors of central obesity. Results: A total of 4,973 male and 1,108 female white-collar workers were included in this study, and the incidence of central obesity was 67.5% and 30.1%, respectively. In male white-collar workers, increasing age, chronic disease, higher levels of total cholesterol, salt intake and BEE, social engagement, eating spicy food and animal offal were risk factors for central obesity, while a higher HDL-C level, eating fish, and high vegetable intake were protective factors. In female white-collar workers, increasing age, higher total cholesterol level, higher BEE, and overeating were risk factors for central obesity, while a higher HDL-C level, and drinking milk were protective factors. Conclusions: Central obesity was a significant public health concern and the prevalence was high in Chinese adults. Healthy lifestyles and dietary measures to control the rates of central obesity should be undertaken to circumvent the growing disease burden in Chinese people..

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Bioactive dietary components—Anti‐obesity effects related to energy metabolism and inflammation

Cited by 18 publications

References 293 publications

The Metabolic Matrix: Re-engineering ultraprocessed foods to feed the gut, protect the liver, and support the brain

The Metabolic Matrix: Re-engineering ultraprocessed foods to feed the gut, protect the liver, and support the brain

Vitamin A: A Key Inhibitor of Adipocyte Differentiation

The prevalence and modifiable lifestyle factors of central obesity among white-collar workers of different genders: A cross-sectional study

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