Bioactive Dimeric Diterpenoids from Taiwania cryptomerioides (Hayata) and Their Biological Activities

Abstract

Taiwania cryptomerioides Hayata is an endangered relict plant belonging to Taxodiaceae, and it is also an endemic plant to China. The decay-resistant of Taiwania timber can provide highly quality wood for building and furniture. Plenty of regenerative of leaves of T. cryptomerioides also has been used as a resource for the discovery of new dimeric diterpenoids. In a search for structurally diverse dimeric diterpenoids and potent bioactive isolates, ten new heterodimeric diterpenoids, taiwaniadducts KÀ T (1 -4, 6, 8-11, and 14), along with five known ones (5, 7, 12, 13, and 15), were isolated from the leaves of T. cryptomerioides. These new compounds were defined by comprehensive spectroscopic analyses, putative biosynthetic pathways, and the values of optical. Biologically, anti-multidrug resistance (MDR) activities of compounds were evaluated. Compounds 4 and 10 exerted a 9.18-fold potentiation effect on bortezmib (BTZ) susceptibility at a tested concentration (20 μM) better than the positive control verapamil. The research of the leaves of T. cryptomerioides not only added the new data to the structural diversity and activities of dimeric diterpenoids but also could provide support for the medical and industrial application of the leaves of this endangered relict plant.

Insecticidal Activity and Molecular Target by Morphological Analysis, RNAseq, and Molecular Docking of the Aryltetralin Lignan Lactone Helioxanthin, Isolated from Taiwania flousiana Gaussen

“…It is one of the most important woods in China with its outstanding quality and has been used in construction, furniture, and paper industries. Therefore, the cultivation and plantation of T. flousiana have received significant attention. − T. flousiana is fast-growing, as high as 80 m, and the timber is decay-resistant; it has become a major economic plantation species in China and can be found in many southern provinces . To date, more than 500 chemicals, including various sesquiterpenes, sesquiterpenoids, dimeric diterpenoids, abietane-type diterpenes, nor- and podocarpane-type diterpenes, sterols, lignans, flavonoids, bisflavones, and cyclitols, have been isolated and identified from this plant.…”

“…7−10 T. f lousiana is fast-growing, as high as 80 m, and the timber is decay-resistant; it has become a major economic plantation species in China and can be found in many southern provinces. 11 To date, more than 500 chemicals, including various sesquiterpenes, sesquiterpenoids, dimeric diterpenoids, abietane-type diterpenes, nor-and podocarpane-type diterpenes, sterols, lignans, flavonoids, bisflavones, and cyclitols, have been isolated and identified from this plant. These chemicals possess different bioactivities such as cytotoxicity, antifungal, algicidal, herbicidal, antimicrobial, anti-inflammatory, anticancer, antitumor, and antioxidant activities.…”